1-aminocyclopropane-1-carboxylic acid (CID 535) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(201)
 
 
Inconclusive(8)
 
 
Unspecified(10)
 
 
Top Targets:
p450(12)
 
 
 
PLN02808(6)
 
 
NR LBD TR(4)
 
 
P53(4)
 
 
PIKKc TOR(4)
 
 
BioAssay Types:
Confirmatory(192)
 
 
 
 
Literature(16)
 
 
 
 
Screening(4)
 
 
BioActivity Types:
Potency(170)
 
 
 
 
EC50(1)
 
 
IC50(1)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 181    Data Row: 225   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103364909]
IC50 0.04In vitro inhibition of [3H]glycine at NMDA receptor [AID145260, Type: Literature]
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2
[SID103364909]
EC50 0.14Compound was evaluated for in vitro inhibition of [3H]-MK-801 at NMDA receptor. [AID144824, Type: Literature]
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3
[SID103364909]
Ki 0.15849Displacement of [3H]glycine from strychnine-insensitive glycine recognition site of NMDA receptor in rat brain cortex membrane [AID430782, Type: Literature]
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4
[SID90340879]
Potency 7.0795qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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5
[SID26749953]
Potency 56.2341qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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6
[SID46393610]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of The Nr1 Ligand-binding Core In Complex With Acpc [gi:73535565]
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7
[SID103364909]
 In vivo antagonist activity against seizures elicited by NMDA in mice, administered intraperitoneally [AID112533, Type: Literature]
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8
[SID103364909]
 Clearance in rat after iv administration [AID540214, Type: Literature]
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9
[SID103364909]
 Clearance in monkey after iv administration [AID540218, Type: Literature]
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10
[SID103364909]
 Volume of distribution at steady state in monkey after iv administration [AID540219, Type: Literature]
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11
[SID103364909]
 Clearance in human after iv administration [AID540220, Type: Literature]
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12
[SID103364909]
 Volume of distribution at steady state in human after iv administration [AID540221, Type: Literature]
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13
[SID103364909]
 Volume of distribution at steady state in rat after iv administration [AID540215, Type: Literature]
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14
[SID103364909]
 Clearance in dog after iv administration [AID540216, Type: Literature]
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15
[SID103364909]
 Volume of distribution at steady state in dog after iv administration [AID540217, Type: Literature]
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16
[SID11110708]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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17
[SID11110708]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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18
[SID90340879]
Potency 5.0119qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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19
[SID90340879]
Potency 25.929qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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20
[SID90340879]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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21
[SID90340879]
Potency qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay [AID588349, Type: confirmatory]
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22
[SID90340879]
Potency qHTS Validation Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID485345, Type: confirmatory]
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23
[SID11110708]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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24
[SID11110708]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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25
[SID11110708]
 qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]UPF0079 ATP-binding protein yjeE [gi:84028058]
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26
[SID26749953]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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27
[SID26749953]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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28
[SID11110708]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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29
[SID11110708]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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30
[SID124879089]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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31
[SID124879088]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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32
[SID90340879]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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33
[SID90340879]
Potency Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation [AID504836, Type: Literature]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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34
[SID90340879]
 Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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35
[SID90340879]
 Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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36
[SID90340879]
 Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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37
[SID90340879]
 Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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38
[SID90340879]
 Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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39
[SID90340879]
 Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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40
[SID90340879]
Potency Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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41
[SID90340879]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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42
[SID90340879]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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43
[SID90340879]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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44
[SID90340879]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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45
[SID90340879]
Potency qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463106, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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46
[SID90340879]
Potency qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463106, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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47
[SID11110708]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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48
[SID11110708]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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49
[SID26749953]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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50
[SID26749953]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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