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AGN-PC-09ST5C (CID 53464134) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Top Targets:
M1 APN 1(1)
 
 
PTZ00371(1)
 
 
Peptidase M17(1)
 
 
BioAssay Types:
Confirmatory(6)
 
 
BioActivity Types:
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID126490285]
Average hM18AAP IC50 0.95Counterscreen for inhibitors of PFM18AAP: QFRET-based biochemical high throughput dose response assay for inhibitors of the human M18 Aspartyl Aminopeptidase (hM18AAP) (2) [AID602221, Type: confirmatory]Chain A, Crystal Structure Of Human Aspartyl Aminopeptidase (Dnpep), In Complex With Aspartic Acid Hydroxamate [gi:291191219]
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2
[SID126490285]
Average IC50 4.3QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP) (1) [AID602222, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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3
[SID126490285]
Average M17 IC50 14.2Counterscreen for inhibitors of PFM18AAP: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M17 Leucine Aminopeptidase (PFM17LAP) (2) [AID602220, Type: confirmatory]M17 leucyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23497510]
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4
[SID126490285]
Average PFM1AAP IC50 29.83Counterscreen for inhibitors of PFM18AAP: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M1AAP (PFM1AAP) (2) [AID602219, Type: confirmatory]m1-family aminopeptidase [Plasmodium falciparum 3D7] [gi:23615263]
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5
[SID126490285]
Average CC50 30.89Vero Cytoxicity Assay: A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP) (2) [AID602225, Type: confirmatory]
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6
[SID126490285]
Avg CC50 45.37Vero Cytoxicity Assay: A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Plasmodium falciparum M17 Leucine Aminopeptidase (PFM17LAP) (3) [AID602317, Type: confirmatory]
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