2-(6-Methyl-1H-benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile (CID 5341736) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(121)
 
 
Inactive(554)
 
 
Inconclusive(46)
 
 
Unspecified(16)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
Death TRAILR..(12)
 
 
 
 
alkPPc(12)
 
 
Bcl-2 like(10)
 
 
 
PP1c bdg(9)
 
 
 
 
BioAssay Types:
Screening(482)
 
 
 
 
 
Confirmatory(234)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(136)
 
 
 
 
 
IC50(63)
 
 
 
 
 
EC50(21)
 
 
 
 
AC50(7)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 718    Data Row: 737   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17413739]
IC50 0.195High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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2
[SID17413739]
AC50 0.195HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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3
[SID17413739]
AC50 0.195HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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4
[SID17413739]
AC50 0.195HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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5
[SID17413739]
AC50 0.195Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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6
[SID17413739]
EC50 0.387Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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7
[SID17413739]
EC50 0.454Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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8
[SID17413739]
EC50 0.604Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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9
[SID17413739]
Potency 0.7308qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID17413739]
Potency 0.7308qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID17413739]
Potency 0.7308qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID17413739]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID17413739]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID17413739]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID17413739]
Potency 1Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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16
[SID17413739]
EC50 1.021High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Dose Response [AID1047, Type: confirmatory]
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17
[SID17413739]
EC50 1.038High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Dose Response [AID1045, Type: confirmatory]
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18
[SID17413739]
EC50 1.25A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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19
[SID17413739]
AC50 1.924Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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20
[SID17413739]
Potency 1.9953qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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21
[SID17413739]
AC50 2.96ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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22
[SID17413739]
Potency 3.1623VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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23
[SID17413739]
Potency 3.2629qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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24
[SID17413739]
Potency 3.2643qHTS for inhibitors of Vif-A3G interactions: Cherry picks [AID651812, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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25
[SID17413739]
Potency 3.2643qHTS for inhibitors of Vif-A3F interactions: Cherry picks [AID651814, Type: confirmatory]APOBEC3F gene product [Homo sapiens] [gi:22907044]
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26
[SID17413739]
IC50 4.858Absorbance-based bacterial cell-based high throughput dose response assay for inhibitors of AddAB recombination protein complex [AID492959, Type: confirmatory]
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27
[SID17413739]
Potency 5.0119qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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28
[SID17413739]
Potency 5.6234qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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29
[SID17413739]
EC50 5.847Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Polyadenylation. [AID2096, Type: confirmatory]
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30
[SID17413739]
Potency 6.3096qHTS for Inhibitors of Vif-A3G Interactions: qHTS [AID602310, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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31
[SID17413739]
Potency 6.5131qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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32
[SID17413739]
EC50 8.372Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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33
[SID17413739]
Potency 8.4921qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay [AID651597, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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34
[SID17413739]
Potency 8.4921qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay [AID651597, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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35
[SID17413739]
Potency 8.4921qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay [AID651597, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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36
[SID17413739]
Potency 8.4921qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay [AID651597, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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37
[SID17413739]
Potency 8.9125qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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38
[SID17413739]
Potency 8.9125qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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39
[SID17413739]
Potency 8.9125qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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40
[SID17413739]
IC50 9.06High Throughput Imaging Assay for Beta-Catenin [AID1665, Type: confirmatory]catenin beta-1 [Homo sapiens] [gi:4503131]
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41
[SID17413739]
IC50 9.06High Throughput Imaging Assay for Beta-Catenin [AID1665, Type: confirmatory]catenin beta-1 [Homo sapiens] [gi:4503131]
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42
[SID17413739]
Potency 9.2A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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43
[SID110522930]
IC50 9.421Late stage results for the probe development effort to identify inhibitors of AddAB recombination protein complex: Absorbance-based bacterial cell-based dose response assay for inhibitors of AddAB recombination protein complex [AID504677, Type: confirmatory]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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44
[SID17413739]
Potency 10qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
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45
[SID17413739]
Potency 10qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
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46
[SID17413739]
Potency 10.3225qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen [AID651815, Type: confirmatory]APOBEC3F gene product [Homo sapiens] [gi:22907044]
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47
[SID17413739]
Potency 10.4179Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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48
[SID17413739]
Potency 12.5893Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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49
[SID17413739]
Potency 18.3489qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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50
[SID17413739]
Potency 18.3564qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen [AID651813, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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