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2-(6-Methyl-1H-benzoimidazol-2-yl)-3-(5-nitro-furan-2-yl)-acrylonitrile (CID 5341736) - Compound BioActivity Data
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BioActivity Outcomes:
Active(141)
 
 
Inactive(641)
 
 
Inconclusive(56)
 
 
Unspecified(16)
 
 
Top Targets:
7tm 4(44)
 
 
 
Death TRAILR..(12)
 
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
 
Tryp SPc(9)
 
 
 
 
BioAssay Types:
Screening(550)
 
 
 
 
 
Confirmatory(271)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(160)
 
 
 
 
 
IC50(75)
 
 
 
 
 
EC50(21)
 
 
 
 
AC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 752    Data Row: 854   Total Pages: 43   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17413739]
IC50 0.195High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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2
[SID17413739]
AC50_uM 0.195Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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3
[SID17413739]
AC50_uM 0.195HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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4
[SID17413739]
EC50 0.387Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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5
[SID17413739]
EC50_uM 0.454Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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6
[SID17413739]
EC50 0.604Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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7
[SID17413739]
Potency 0.7308qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID17413739]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID17413739]
Potency 1Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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10
[SID17413739]
EC50 1.021High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Dose Response [AID1047, Type: confirmatory]
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11
[SID17413739]
EC50 1.038High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Dose Response [AID1045, Type: confirmatory]
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12
[SID17413739]
EC50 1.25A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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13
[SID17413739]
AC50_uM 1.924Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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14
[SID17413739]
Potency 1.9953qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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15
[SID17413739]
AC50_uM 2.96ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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16
[SID17413739]
Potency 3.1623VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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17
[SID17413739]
Potency 3.2629qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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18
[SID17413739]
Potency 3.2643qHTS for inhibitors of Vif-A3G interactions: Cherry picks [AID651812, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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19
[SID17413739]
Potency 3.2643qHTS for inhibitors of Vif-A3F interactions: Cherry picks [AID651814, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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20
[SID17413739]
Potency 4.6109qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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