AC1NSUL9 (CID 5339969) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(65)
 
 
Inactive(417)
 
 
Inconclusive(16)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
HSF(5)
 
 
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(325)
 
 
 
 
Confirmatory(164)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(30)
 
 
 
 
EC50(18)
 
 
 
 
AC50(12)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 499    Data Row: 499   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49668693]
Potency 0.2512qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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2
[SID49668693]
Potency 0.5623qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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3
[SID49668693]
Potency 0.5623qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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4
[SID103023265]
AC50 0.994HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_Dose_DryPowder_Activity [AID602269, Type: confirmatory]
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5
[SID49668693]
AC50 1.324HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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6
[SID49668693]
AC50 1.324HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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7
[SID49668693]
AC50 1.324HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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8
[SID49668693]
Potency 1.4716Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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9
[SID49668693]
EC50 1.51Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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10
[SID49668693]
AbsAC35_uM 1.61Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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11
[SID49668693]
Potency 1.636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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12
[SID103023265]
AC50 1.72Heat Shock Factor-1 (HSF-1) Luciferase Reporter Measured in Cell-Based System Using Plate Reader - 2038-01_Inhibitor_Dose_DryPowder_Activity [AID602268, Type: confirmatory]
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13
[SID49668693]
AC50 1.976Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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14
[SID49668693]
EC50 2.591Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole [AID2423, Type: confirmatory]heat shock protein 90 [Candida albicans] [gi:994798]
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15
[SID49668693]
AC50 2.673Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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16
[SID49668693]
AbsAC35_uM 2.68Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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17
[SID49668693]
Potency 2.8184qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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18
[SID49668693]
Potency 2.8184qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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19
[SID49668693]
Potency 2.8184qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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20
[SID49668693]
Potency 2.8184qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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21
[SID49668693]
EC50 3.192Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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22
[SID49668693]
EC50 3.192Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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23
[SID49668693]
AC50 3.27ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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24
[SID49668693]
AC50 3.27ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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25
[SID49668693]
Potency 3.5481qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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26
[SID49668693]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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27
[SID49668693]
AC50 4.279ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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28
[SID49668693]
AbsAC1000_uM 5.391In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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29
[SID49668693]
Potency 5.6234qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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30
[SID49668693]
IC50 5.94Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. [AID504672, Type: confirmatory]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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31
[SID49668693]
Potency 6.5131qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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32
[SID49668693]
EC50 6.833Luminescence Cell-Based Confirmation at Dose to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID2089, Type: confirmatory]
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33
[SID49668693]
IC50 6.87Dose Response confirmation of uHTS small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID493002, Type: confirmatory]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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34
[SID49668693]
EC50 7.01Fluorescent Cell-Based Secondary Screen to Identify Activators of the Hypoxia Factor Pathway [AID434951, Type: confirmatory]
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35
[SID49668693]
Potency 8.4921qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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36
[SID49668693]
Potency 9.2A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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37
[SID49668693]
Potency 10VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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38
[SID49668693]
EC50 22.543Luminescent Cell-Based Dose Titration Retest Counterscreen to Identify Proteasome Inhibitors [AID2486, Type: confirmatory]
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39
[SID49668693]
EC50 22.73Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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40
[SID49668693]
Potency 28.1838qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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41
[SID49668693]
Potency 28.1838qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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42
[SID49668693]
Potency 28.1838qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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43
[SID49668693]
Potency 28.1838qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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44
[SID49668693]
Potency 31.6228qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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45
[SID49668693]
AC50 38.933HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493083, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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46
[SID49668693]
AC50 38.933HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493083, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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47
[SID49668693]
AC50 56.5ARNT-TACC3: counter AlphaScreen Measured in Biochemical System Using Plate Reader - 2158-02_Inhibitor_Dose_CherryPick_Activity [AID651705, Type: confirmatory]
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48
[SID49668693]
AbsAC35_uM 82.89Mammalian cell toxicity counterscreen to identify toxic HSP40 inhibitor compounds in NIH3T3 cells Measured in Cell-Based System Using Plate Reader - 2120-03_Inhibitor_Dose_CherryPick_Activity_Set2 [AID624265, Type: confirmatory]
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49
[SID49668693]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]
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50
[SID49668693]
 Fluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compound [AID1979, Type: screening]heat shock protein 90 [Candida albicans] [gi:994798]
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