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3-(4-chlorophenyl)-4-[(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2H-1,2-oxazol-5-one (CID 5337766) - Compound BioActivity Data
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BioActivity Outcomes:
Active(38)
 
 
Inactive(556)
 
 
Inconclusive(41)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(30)
 
 
 
Bcl-2 like(12)
 
 
 
alkPPc(10)
 
 
Esterase lipa..(9)
 
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(400)
 
 
 
 
Confirmatory(210)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(147)
 
 
 
 
 
IC50(41)
 
 
 
EC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 583    Data Row: 636   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24813372]
Potency 0.4744qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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2
[SID24813372]
IC50 2.278Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) [AID504317, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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3
[SID24813372]
IC50 2.278Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) [AID504317, Type: confirmatory]perilipin-1 [Homo sapiens] [gi:223718203]
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4
[SID24813372]
IC50 3.103Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) (2K validation set) [AID504319, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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5
[SID24813372]
IC50 3.103Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) (2K validation set) [AID504319, Type: confirmatory]perilipin-5 [Homo sapiens] [gi:116292172]
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6
[SID24813372]
Potency 3.1623qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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7
[SID24813372]
Potency 6.3096qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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8
[SID24813372]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID24813372]
EC50_Mean 8.29Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504549, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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10
[SID24813372]
Potency 9.4662qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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11
[SID24813372]
Potency 10.691qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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12
[SID24813372]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID24813372]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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14
[SID24813372]
Potency 21.5227qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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15
[SID24813372]
Potency 22.3872qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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16
[SID24813372]
Potency 22.3872qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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17
[SID24813372]
Potency 25.7247qHTS Assay for Inhibitors of GCN5L2: Hit confirmation [AID588347, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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18
[SID24813372]
Potency 50.1187qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID24813372]
Luminescence-based biochemical high throughput validation assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) [AID493027, Type: screening]perilipin-1 [Homo sapiens] [gi:223718203]
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20
[SID24813372]
Single concentration confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504550, Type: screening]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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