AC1NSPJW (CID 5337766) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(31)
 
 
Inactive(472)
 
 
Inconclusive(37)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
 
G-alpha(6)
 
 
 
7TM GPCR Srsx(6)
 
 
BioAssay Types:
Screening(346)
 
 
 
 
Confirmatory(179)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
IC50(35)
 
 
 
EC50(15)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 541    Data Row: 541   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24813372]
IC50 2.278Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) [AID504317, Type: confirmatory]ABHD5 gene product [Homo sapiens] [gi:31542303]
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2
[SID24813372]
IC50 3.103Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) (2K validation set) [AID504319, Type: confirmatory]ABHD5 gene product [Homo sapiens] [gi:31542303]
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3
[SID24813372]
Potency 3.1623qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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4
[SID24813372]
Potency 3.1623qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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5
[SID24813372]
Potency 6.3096qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
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6
[SID24813372]
Potency 6.3096qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
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7
[SID24813372]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID24813372]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID24813372]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID24813372]
EC50 8.29Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504549, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
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11
[SID24813372]
EC50 8.29Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504549, Type: confirmatory]NTSR1 gene product [Homo sapiens] [gi:110611243]
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12
[SID24813372]
Potency 9.4662qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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13
[SID24813372]
Potency 10.691qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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14
[SID24813372]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID24813372]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID24813372]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID24813372]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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18
[SID24813372]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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19
[SID24813372]
Potency 22.3872qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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20
[SID24813372]
Potency 22.3872qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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21
[SID24813372]
Potency 25.7247qHTS Assay for Inhibitors of GCN5L2: Hit confirmation [AID588347, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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22
[SID24813372]
Potency 25.7247qHTS Assay for Inhibitors of GCN5L2: Hit confirmation [AID588347, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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23
[SID24813372]
Potency 50.1187qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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24
[SID24813372]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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25
[SID24813372]
 Leishmania major promastigote HTS [AID1063, Type: screening]
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26
[SID24813372]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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27
[SID24813372]
 HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. [AID1381, Type: screening]
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28
[SID24813372]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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29
[SID24813372]
 HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules: Confirmation Assay [AID463116, Type: screening]
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30
[SID24813372]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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31
[SID24813372]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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32
[SID24813372]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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33
[SID24813372]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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34
[SID24813372]
 Single concentration confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504550, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
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35
[SID24813372]
 Single concentration confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504550, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
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36
[SID24813372]
 Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
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37
[SID24813372]
 Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
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38
[SID24813372]
 Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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39
[SID24813372]
 Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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40
[SID24813372]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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41
[SID24813372]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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42
[SID24813372]
 Luminescence-based biochemical high throughput validation assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) [AID493027, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
View
43
[SID24813372]
 Luminescence-based biochemical high throughput validation assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID493035, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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44
[SID24813372]
 Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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45
[SID24813372]
 Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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46
[SID24813372]
 Confirmatory screen for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID2032, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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47
[SID24813372]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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48
[SID24813372]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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49
[SID24813372]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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50
[SID24813372]
Potency 25.1189qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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