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MLS003874819 (CID 53364507) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(21)
 
 
Inactive(107)
 
 
Unspecified(4)
 
 
Top Targets:
Hydrolase 4(16)
 
 
PAF-AH p II(12)
 
 
 
 
 
Peptidase S9(11)
 
 
Peptidase S9(8)
 
 
ZnMc TACE lik..(6)
 
 
 
BioAssay Types:
Screening(31)
 
 
 
Confirmatory(7)
 
 
 
Summary(5)
 
 
 
BioActivity Types:
IC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 44    Data Row: 133   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID125269079]
Summary of probe development efforts to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463092, Type: summary]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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2
[SID125269079]
Average IC50 0.006Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH): fluorescence-based dose response biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of human pPAFAH [AID588766, Type: confirmatory]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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3
[SID125269079]
Average IC50 0.031Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based dose-response biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assay for SAR compounds [AID588770, Type: confirmatory]Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus] [gi:14715116]
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4
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition and selectivity of SAR compounds in a complex proteome [AID588774_1, Type: other]Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus] [gi:14715116]
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5
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH and selectivity analysis in vivo [AID588823_1, Type: other]Es1 protein [Mus musculus] [gi:22135640]
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6
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_1, Type: other]platelet-activating factor acetylhydrolase precursor [Mus musculus] [gi:31980752]
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7
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_1, Type: other]platelet-activating factor acetylhydrolase precursor [Mus musculus] [gi:31980752]
View
8
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH in vivo [AID588789, Type: other]platelet-activating factor acetylhydrolase precursor [Mus musculus] [gi:31980752]
View
9
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH in situ [AID588817, Type: other]platelet-activating factor acetylhydrolase precursor [Mus musculus] [gi:31980752]
View
10
[SID143472339]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
View
11
[SID143472339]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM17 [AID743257, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
View
12
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical assay to determine binding mode of test compounds [AID588788, Type: other]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
View
13
[SID143472339]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
View
14
[SID143472339]
Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of COUP-TFII (NR2F2) [AID687008, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
View
15
[SID143472339]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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16
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_39, Type: other]carboxylesterase 1C precursor [Mus musculus] [gi:247269929]
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17
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_15, Type: other]carboxylesterase 1C precursor [Mus musculus] [gi:247269929]
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18
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH and selectivity analysis in vivo [AID588823_2, Type: other]carboxylesterase 1C precursor [Mus musculus] [gi:247269929]
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19
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition and selectivity of SAR compounds in a complex proteome [AID588774, Type: other]
View
20
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785, Type: other]
View
21
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787, Type: other]
View
22
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH and selectivity analysis in vivo [AID588823, Type: other]
View
23
[SID125269079]
Summary of probe development efforts to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463092_2, Type: summary]Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus] [gi:14715116]
View
24
[SID125269079]
Summary of probe development efforts to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463092_1, Type: summary]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
View
25
[SID125269079]
Summary of probe development efforts to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463092_3, Type: summary]
View
26
[SID125269079]
Summary of probe development efforts to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463092_4, Type: summary]
View
27
[SID125269079]
6.7Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH): absorbance-based cell-based dose response assay to determine cytotoxicity of inhibitor compounds [AID588768_1, Type: confirmatory]
View
28
[SID125269079]
35Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH): absorbance-based cell-based dose response assay to determine cytotoxicity of inhibitor compounds [AID588768_2, Type: confirmatory]
View
29
[SID143472339]
IC50 69.378QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17 [AID743260, Type: confirmatory]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
View
30
[SID143472339]
IC50 69.378Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10 [AID743259, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
View
31
[SID143472339]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
View
32
[SID143472339]
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) [AID720596, Type: screening]major prion protein preproprotein [Homo sapiens] [gi:4506113]
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33
[SID143472339]
Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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34
[SID143472339]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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35
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_37, Type: other]acyl-protein thioesterase 1 [Mus musculus] [gi:6678760]
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36
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_11, Type: other]acyl-protein thioesterase 1 [Mus musculus] [gi:6678760]
View
37
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_35, Type: other]platelet-activating factor acetylhydrolase IB subunit gamma [Mus musculus] [gi:6679201]
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38
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_19, Type: other]platelet-activating factor acetylhydrolase IB subunit gamma [Mus musculus] [gi:6679201]
View
39
[SID143472339]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
View
40
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_14, Type: other]acyl-coenzyme A thioesterase 1 [Mus musculus] [gi:6753550]
View
41
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_8, Type: other]acyl-coenzyme A thioesterase 1 [Mus musculus] [gi:6753550]
View
42
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_10, Type: other]prolyl endopeptidase [Mus musculus] [gi:6755152]
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43
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_3, Type: other]prolyl endopeptidase [Mus musculus] [gi:6755152]
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44
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_15, Type: other]acyl-protein thioesterase 2 [Mus musculus] [gi:7242156]
View
45
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_5, Type: other]acyl-protein thioesterase 2 [Mus musculus] [gi:7242156]
View
46
[SID143472339]
Counterscreen for antagonists of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID687007, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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47
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_30, Type: other]serine beta-lactamase-like protein LACTB, mitochondrial precursor [Mus musculus] [gi:13507666]
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48
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_17, Type: other]acetylcholinesterase precursor [Mus musculus] [gi:13928664]
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49
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_4, Type: other]S-formylglutathione hydrolase isoform 2 [Mus musculus] [gi:13937355]
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50
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_2, Type: other]S-formylglutathione hydrolase isoform 2 [Mus musculus] [gi:13937355]
View