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AGN-PC-09REOE (CID 53364507) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(21)
 
 
Inactive(108)
 
 
Unspecified(4)
 
 
Top Targets:
Hydrolase 4(16)
 
 
PAF-AH p II(12)
 
 
 
 
 
Peptidase S9(11)
 
 
Peptidase S9(8)
 
 
ZnMc TACE lik..(6)
 
 
 
BioAssay Types:
Screening(32)
 
 
 
Confirmatory(7)
 
 
 
Summary(5)
 
 
 
BioActivity Types:
IC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 134   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID125269079]
Summary of probe development efforts to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463092, Type: summary]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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2
[SID125269079]
Average IC50 0.006Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH): fluorescence-based dose response biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of human pPAFAH [AID588766, Type: confirmatory]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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3
[SID125269079]
Average IC50 0.031Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based dose-response biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assay for SAR compounds [AID588770, Type: confirmatory]Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus] [gi:14715116]
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4
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785, Type: other]
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5
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787, Type: other]
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6
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH and selectivity analysis in vivo [AID588823, Type: other]
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7
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_1, Type: other]platelet-activating factor acetylhydrolase precursor [Mus musculus] [gi:31980752]
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8
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_1, Type: other]platelet-activating factor acetylhydrolase precursor [Mus musculus] [gi:31980752]
View
9
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH in vivo [AID588789, Type: other]platelet-activating factor acetylhydrolase precursor [Mus musculus] [gi:31980752]
View
10
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH in situ [AID588817, Type: other]platelet-activating factor acetylhydrolase precursor [Mus musculus] [gi:31980752]
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11
[SID143472339]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM17 [AID743257, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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12
[SID143472339]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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13
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH and selectivity analysis in vivo [AID588823_1, Type: other]Es1 protein [Mus musculus] [gi:22135640]
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14
[SID143472339]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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15
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome [AID588785_39, Type: other]carboxylesterase 1C precursor [Mus musculus] [gi:247269929]
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16
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain soluble proteome [AID588787_15, Type: other]carboxylesterase 1C precursor [Mus musculus] [gi:247269929]
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17
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of pPAFAH and selectivity analysis in vivo [AID588823_2, Type: other]carboxylesterase 1C precursor [Mus musculus] [gi:247269929]
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18
[SID143472339]
Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of COUP-TFII (NR2F2) [AID687008, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
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19
[SID143472339]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
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20
[SID125269079]
Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition and selectivity of SAR compounds in a complex proteome [AID588774_1, Type: other]Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus] [gi:14715116]
View