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SR-03000002453 (CID 53338912) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(3)
 
 
Top Targets:
Lactamase B(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 5    Data Row: 5   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID125001871]
MIC [4 fold reduction] 3.125Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): Growth inhibition of clinically relevant VIM-2-transformed Acinetobacter species (YMC07/8/B3323) in the presence of imipenem (synergy) [AID624096, Type: other]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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2
[SID125001871]
MIC [4 fold reduction] 6.2Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): VIM-2-transformed E. coli growth inhibition in the presence of imipenem (synergy) [AID624081, Type: other]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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3
[SID125001871]
MIC [4 fold reduction] 100Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): Growth inhibition of clinically relevant New Delhi metallo-beta-lactamase-1 (NDM-1)-transformed K. pneumoniae (BAA-2146) in the presence of imipenem (synergy) [AID624082, Type: other]NDM-1 metallo-beta-lactamase [Escherichia coli] [gi:345105285]
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4
[SID125001871]
MIC [4 fold reduction] 100Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): Growth inhibition of clinically relevant IMP-1 transformed P. aeruginosa (KN20) in the presence of imipenem (synergy) [AID624095, Type: other]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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5
[SID125001871]
MIC [4 fold reduction] 100Late stage assay provider results from the probe development efforts to identify inhibitors of VIM-2 metallo-beta-lactamase (nonselective): Growth inhibition of clinically relevant VIM-2 transformed P. aeruginosa (PA641) in the presence of imipenem (synergy) [AID624080, Type: other]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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