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AN-329/10734033 (CID 5332280) - Compound BioActivity Data
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BioActivity Outcomes:
Active(31)
 
 
Inactive(652)
 
 
Inconclusive(17)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(20)
 
 
Bcl-2 like(11)
 
 
 
alkPPc(10)
 
 
Peptidase C48(8)
 
 
 
BioAssay Types:
Screening(477)
 
 
 
 
 
Confirmatory(205)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(39)
 
 
 
 
EC50(10)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 641    Data Row: 702   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22413272]
Potency 2.5119qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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2
[SID22413272]
Potency 8.9125qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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3
[SID22413272]
Potency 11.2202qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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4
[SID22413272]
Potency 15.8489qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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5
[SID22413272]
AC50_uM 18.93Luminescence assay for the detection of hydrogen peroxide activity in the abscence of ALR and DTT, at dose Measured in Biochemical System Using Plate Reader - 2036-03_Inhibitor_Dose_CherryPick_Activity [AID540356, Type: confirmatory]
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6
[SID22413272]
IC50 30.41Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP) [AID1619, Type: confirmatory]M17 leucyl aminopeptidase [Plasmodium falciparum 3D7] [gi:124809582]
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7
[SID22413272]
IC50 33.24Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Counter Screen Coupled Enzyme [AID624351, Type: confirmatory]
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8
[SID22413272]
IC50 44.54Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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9
[SID22413272]
Potency 60.1198qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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10
[SID22413272]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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11
[SID22413272]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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12
[SID22413272]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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13
[SID22413272]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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14
[SID22413272]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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15
[SID22413272]
uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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16
[SID22413272]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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17
[SID22413272]
Single concentration confirmation of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID485299, Type: screening]
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18
[SID22413272]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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19
[SID22413272]
Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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20
[SID22413272]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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21
[SID22413272]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ras and Rab interactor 1 [Homo sapiens] [gi:68989256]
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22
[SID22413272]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]tyrosine-protein kinase ABL1 isoform a [Homo sapiens] [gi:62362414]
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23
[SID22413272]
uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary Assays [AID1217, Type: screening]Dihydrolipoamide dehydrogenase [Homo sapiens] [gi:17391426]
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24
[SID22413272]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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25
[SID22413272]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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26
[SID22413272]
QFRET-based biochemical high throughput confirmation assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2170, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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27
[SID22413272]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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28
[SID22413272]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay [AID488917, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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29
[SID22413272]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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30
[SID22413272]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay [AID488919, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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31
[SID22413272]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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32
[SID22413272]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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33
[SID22413272]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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34
[SID22413272]
Potency 10qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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35
[SID22413272]
EC50_Mean 46.7Dose response counterscreen for uHTS small molecule activators of the adaptive arm of the Unfolded Protein Response via a luminescent-based reporter assay [AID489027, Type: confirmatory]
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36
[SID22413272]
EC50_Mean 80Dose response confirmation of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID489032, Type: confirmatory]
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37
[SID22413272]
HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. [AID463075, Type: screening]
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38
[SID22413272]
Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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39
[SID22413272]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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40
[SID22413272]
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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41
[SID22413272]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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42
[SID22413272]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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43
[SID22413272]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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44
[SID22413272]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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45
[SID22413272]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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46
[SID22413272]
IC50 A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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47
[SID22413272]
Potency qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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48
[SID22413272]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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49
[SID22413272]
Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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50
[SID22413272]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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