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AGN-PC-09QE2V (CID 53313056) - Compound BioActivity Data
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BioActivity Outcomes:
Active(51)
 
 
Inactive(292)
 
 
Inconclusive(14)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(10)
 
 
B zip1(4)
 
 
 
alkPPc(4)
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(235)
 
 
 
 
Confirmatory(106)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(89)
 
 
 
 
 
IC50(11)
 
 
 
AC50(3)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 317    Data Row: 358   Total Pages: 18   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID74374078]
IC50_Mean 0.17Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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2
[SID74374078]
Potency 0.3264qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID74374078]
IC50_Mean 0.41Dose response counterscreen of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489020, Type: confirmatory]
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4
[SID74374078]
Potency 0.4109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID74374078]
IC50_Mean 0.593Dose response confirmation of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489034, Type: confirmatory]
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6
[SID74374078]
Potency 0.631qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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7
[SID74374078]
EC50_uM 0.8826Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2821, Type: confirmatory]serine/threonine-protein kinase 33 isoform a [Homo sapiens] [gi:23943882]
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8
[SID74374078]
Potency 1.122qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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9
[SID74374078]
Potency 1.2589qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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10
[SID74374078]
AC50_uM 1.482Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504545, Type: confirmatory]CDK5 [Homo sapiens] [gi:48146199]
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11
[SID74374078]
AC50_uM 1.482Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504545, Type: confirmatory]Cyclin-dependent kinase 5, regulatory subunit 1 (p35) [Homo sapiens] [gi:20072248]
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12
[SID74374078]
Potency 1.7783qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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13
[SID74374078]
Potency 2.31qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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14
[SID74374078]
Potency 2.3109qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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15
[SID74374078]
Potency 2.5929Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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16
[SID74374078]
Potency 2.5929Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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17
[SID74374078]
Potency 8.1995Nrf2 qHTS screen for inhibitors: A549 ARE-Fluc Cytotoxicity Counterscreen for Hit Validation [AID720523, Type: confirmatory]
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18
[SID74374078]
Potency 18.3564Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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19
[SID74374078]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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20
[SID74374078]
Single concentration confirmation of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435020, Type: screening]
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