MLS003884832 (CID 53301934) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(21)
 
 
Inactive(4)
 
 
Inconclusive(3)
 
 
Top Targets:
Ras like GTPa..(6)
 
 
 
Rab7(4)
 
 
 
Rac1 like(4)
 
 
 
RhoA like(2)
 
 
GST N Mu(1)
 
 
BioAssay Types:
Confirmatory(10)
 
 
 
BioActivity Types:
EC50(10)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 28   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124756597]
EC50 0.03SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1 [AID588388, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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2
[SID124756597]
EC50 0.03SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1 [AID588388, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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3
[SID124756597]
EC50 0.03SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1 [AID588388, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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4
[SID124756597]
EC50 0.033SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588387, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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5
[SID124756597]
EC50 0.033SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588387, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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6
[SID124756597]
EC50 0.033SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588387, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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7
[SID124756597]
EC50 0.054SAR compounds for Rab7 project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588384, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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8
[SID124756597]
EC50 0.055SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 1 [AID588394, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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9
[SID124756597]
EC50 0.082SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588385, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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10
[SID124756597]
EC50 0.205SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2 [AID588628, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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11
[SID124756597]
EC50 0.205SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2 [AID588628, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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12
[SID124756597]
EC50 0.205SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2 [AID588628, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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13
[SID124756597]
EC50 0.275SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2 [AID588630, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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14
[SID124756597]
EC50 0.275SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2 [AID588630, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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15
[SID124756597]
EC50 0.275SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2 [AID588630, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
16
[SID124756597]
EC50 0.295SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 2 [AID588631, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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17
[SID124756597]
EC50 1.314SAR compounds for Rab7 project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 2 [AID588624, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
18
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_4, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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19
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_5, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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20
[SID124756597]
 Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_5, Type: other]GTPase [Homo sapiens] [gi:407699]
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21
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_8, Type: other]GTPase [Homo sapiens] [gi:407699]
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22
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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23
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_1, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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24
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_2, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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25
[SID124756597]
 Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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26
[SID124756597]
 Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_1, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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27
[SID124756597]
 Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_2, Type: other]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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28
[SID124756597]
 EGFR degradation assay in SCC-12F cells [AID602146, Type: other]epidermal growth factor receptor [Homo sapiens] [gi:326467049]
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29
[SID124756597]
 EGFR degradation assay in SCC-12F cells [AID602146, Type: other]epidermal growth factor receptor [Homo sapiens] [gi:326467049]
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30
[SID124756597]
 EGFR degradation assay in SCC-12F cells [AID602146, Type: other]epidermal growth factor receptor [Homo sapiens] [gi:326467049]
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31
[SID124756597]
 Active GTPase Screen Compounds affects on binding of VLA-4 specific ligand [AID602148, Type: other]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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32
[SID124756597]
 Active GTPase Screen Compounds affects on binding of VLA-4 specific ligand [AID602148, Type: other]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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33
[SID124756597]
 Counter screen to determine effect of SAR compounds for Rab7 project on GST-GSH binding, round 1 [AID602137, Type: other]glutathione S-transferase [Homo sapiens] [gi:31933]
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34
[SID124756597]
 Counter screen to determine effect of SAR compounds for Rab7 project on GST-GSH binding, round 1 [AID602137, Type: other]glutathione S-transferase [Homo sapiens] [gi:31933]
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35
[SID124756597]
 Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_3, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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36
[SID124756597]
 Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_4, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
View
37
[SID124756597]
EC50 SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 2 [AID588626, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
38
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_6, Type: other]ras protein [Homo sapiens] [gi:190938]
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39
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_7, Type: other]ras protein [Homo sapiens] [gi:190938]
View
40
[SID124756597]
 Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_3, Type: other]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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