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MLS003591341 (CID 53301265) - Compound BioActivity Data
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BioActivity Outcomes:
Active(44)
 
 
Inactive(133)
 
 
Inconclusive(6)
 
 
Unspecified(8)
 
 
Top Targets:
Death TRAILR..(12)
 
 
 
 
7tm 4(10)
 
 
 
PKS(4)
 
 
RasGEF(4)
 
 
 
NR DBD CAR(3)
 
 
BioAssay Types:
Screening(140)
 
 
 
 
 
Confirmatory(41)
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(30)
 
 
 
 
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 165    Data Row: 191   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124755436]
IC50 2.187Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID651553, Type: confirmatory]receptor-interacting serine/threonine-protein kinase 2 [Homo sapiens] [gi:4506537]
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2
[SID124755436]
IC50 2.187Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID651553, Type: confirmatory]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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3
[SID124755436]
Potency 2.3109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID124755436]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID124755436]
Potency 2.9935qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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6
[SID124755436]
AbsAC35_uM 3.95HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720589, Type: confirmatory]
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7
[SID124755436]
AbsAC35_uM 5.01Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_CherryPick_Activity [AID720587, Type: confirmatory]
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8
[SID124755436]
AbsAC35_uM 5.49Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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9
[SID124755436]
Potency 5.8048qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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10
[SID124755436]
IC50 6.12Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID624327, Type: confirmatory]fatty acid synthase [Homo sapiens] [gi:41872631]
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11
[SID124755436]
IC50 6.79Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay [AID624326, Type: confirmatory]fatty acid synthase [Homo sapiens] [gi:41872631]
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12
[SID124755436]
Potency 8.1995qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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13
[SID124755436]
AbsAC35_uM 9.24HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720588, Type: confirmatory]
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14
[SID124755436]
Potency 12.5893qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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15
[SID124755436]
Max_Activity_Conc_uM 26Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent TC71 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-04_Inhibitor_Dose_CherryPick_Activity [AID720570, Type: confirmatory]
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16
[SID124755436]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
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17
[SID124755436]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
View
18
[SID124755436]
Fluorescence-based cell-based high throughput confirmation assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624370, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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19
[SID124755436]
Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify nonselective inhibitors of the Steroidogenic acute regulatory protein (StAR) promoter or luminescence assay artifacts [AID651611, Type: screening]
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20
[SID124755436]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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