urea deriv. 25 (CID 5329831) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(2)
 
 
Inconclusive(1)
 
 
Unspecified(454)
 
 
Top Targets:
PKc(48)
 
 
PKc like(40)
 
 
STKc AGC(28)
 
 
PTKc Abl(16)
 
 
PTKc EGFR(10)
 
 
BioAssay Types:
Confirmatory(3)
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(3)
 
 
 
 
IC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 460    Data Row: 460   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103457339]
IC50 0.029Inhibitory concentration against human umbilical vein endothelial cells (HUVECs) induced by VEGF [AID248167, Type: Literature]
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2
[SID103457339]
IC50 0.065Inhibitory concentration against human VEGFR2 kinase [AID240506, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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3
[SID103457339]
IC50 0.065Inhibitory concentration against human VEGFR2 kinase [AID240506, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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4
[SID124350076]
Potency 0.5799qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652016, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID103457339]
 GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651370, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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6
[SID103457339]
 GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651370, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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7
[SID103457339]
 GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 1 uM [Nanosyn] [AID651371, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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8
[SID103457339]
 GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 1 uM [Nanosyn] [AID651371, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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9
[SID103457339]
 GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651372, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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10
[SID103457339]
 GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651372, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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11
[SID103457339]
 GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 1 uM [Nanosyn] [AID651373, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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12
[SID103457339]
 GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 1 uM [Nanosyn] [AID651373, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103457339]
 GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651374, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID103457339]
 GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651374, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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15
[SID103457339]
 GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 1 uM [Nanosyn] [AID651375, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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16
[SID103457339]
 GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 1 uM [Nanosyn] [AID651375, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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17
[SID103457339]
 GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651376, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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18
[SID103457339]
 GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651376, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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19
[SID103457339]
 GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 1 uM [Nanosyn] [AID651377, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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20
[SID103457339]
 GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 1 uM [Nanosyn] [AID651377, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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21
[SID103457339]
 GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651378, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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22
[SID103457339]
 GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651378, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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23
[SID103457339]
 GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 1 uM [Nanosyn] [AID651379, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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24
[SID103457339]
 GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 1 uM [Nanosyn] [AID651379, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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25
[SID103457339]
 GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651380, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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26
[SID103457339]
 GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651380, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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27
[SID103457339]
 GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 1 uM [Nanosyn] [AID651381, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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28
[SID103457339]
 GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 1 uM [Nanosyn] [AID651381, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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29
[SID103457339]
 GSK_PKIS: ABL1 mean inhibition at 0.1 uM [Nanosyn] [AID651382, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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30
[SID103457339]
 GSK_PKIS: ABL1 mean inhibition at 0.1 uM [Nanosyn] [AID651382, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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31
[SID103457339]
 GSK_PKIS: ABL1 mean inhibition at 1 uM [Nanosyn] [AID651383, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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32
[SID103457339]
 GSK_PKIS: ABL1 mean inhibition at 1 uM [Nanosyn] [AID651383, Type: other]Tyrosine-protein kinase ABL1 [gi:85681908]
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33
[SID103457339]
 GSK_PKIS: ARG mean inhibition at 0.1 uM [Nanosyn] [AID651386, Type: other]Abelson tyrosine-protein kinase 2 [gi:1168268]
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34
[SID103457339]
 GSK_PKIS: ARG mean inhibition at 0.1 uM [Nanosyn] [AID651386, Type: other]Abelson tyrosine-protein kinase 2 [gi:1168268]
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35
[SID103457339]
 GSK_PKIS: ARG mean inhibition at 1 uM [Nanosyn] [AID651387, Type: other]Abelson tyrosine-protein kinase 2 [gi:1168268]
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36
[SID103457339]
 GSK_PKIS: ARG mean inhibition at 1 uM [Nanosyn] [AID651387, Type: other]Abelson tyrosine-protein kinase 2 [gi:1168268]
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37
[SID103457339]
 GSK_PKIS: AKT1 mean inhibition at 1 uM [Nanosyn] [AID651019, Type: other]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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38
[SID103457339]
 GSK_PKIS: AKT1 mean inhibition at 1 uM [Nanosyn] [AID651019, Type: other]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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39
[SID103457339]
 GSK_PKIS: AKT1 mean inhibition at 1 uM [Nanosyn] [AID651019, Type: other]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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40
[SID103457339]
 GSK_PKIS: AKT1 mean inhibition at 0.1 uM [Nanosyn] [AID651018, Type: other]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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41
[SID103457339]
 GSK_PKIS: AKT1 mean inhibition at 0.1 uM [Nanosyn] [AID651018, Type: other]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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42
[SID103457339]
 GSK_PKIS: AKT1 mean inhibition at 0.1 uM [Nanosyn] [AID651018, Type: other]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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43
[SID103457339]
 GSK_PKIS: AKT2 mean inhibition at 0.1 uM [Nanosyn] [AID651020, Type: other]RAC-beta serine/threonine-protein kinase [gi:1170703]
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44
[SID103457339]
 GSK_PKIS: AKT2 mean inhibition at 0.1 uM [Nanosyn] [AID651020, Type: other]RAC-beta serine/threonine-protein kinase [gi:1170703]
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45
[SID103457339]
 GSK_PKIS: AKT2 mean inhibition at 0.1 uM [Nanosyn] [AID651020, Type: other]RAC-beta serine/threonine-protein kinase [gi:1170703]
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46
[SID103457339]
 GSK_PKIS: AKT2 mean inhibition at 1 uM [Nanosyn] [AID651021, Type: other]RAC-beta serine/threonine-protein kinase [gi:1170703]
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47
[SID103457339]
 GSK_PKIS: AKT2 mean inhibition at 1 uM [Nanosyn] [AID651021, Type: other]RAC-beta serine/threonine-protein kinase [gi:1170703]
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48
[SID103457339]
 GSK_PKIS: AKT2 mean inhibition at 1 uM [Nanosyn] [AID651021, Type: other]RAC-beta serine/threonine-protein kinase [gi:1170703]
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49
[SID103457339]
 GSK_PKIS: ALK mean inhibition at 0.1 uM [Nanosyn] [AID651384, Type: other]ALK tyrosine kinase receptor [gi:296439447]
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50
[SID103457339]
 GSK_PKIS: ALK mean inhibition at 0.1 uM [Nanosyn] [AID651384, Type: other]ALK tyrosine kinase receptor [gi:296439447]
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