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GW809897X (CID 5329831) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(7)
 
 
Inconclusive(1)
 
 
Unspecified(456)
 
 
Top Targets:
PKc like(42)
 
 
PKc(42)
 
 
STKc AGC(16)
 
 
PTKc Abl(16)
 
 
PTKc Src like(11)
 
 
 
BioAssay Types:
Confirmatory(5)
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(6)
 
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 468    Data Row: 468   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103457339]
IC50 0.029Inhibitory concentration against human umbilical vein endothelial cells (HUVECs) induced by VEGF [AID248167, Type: Literature]
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2
[SID103457339]
IC50 0.065Inhibitory concentration against human VEGFR2 kinase [AID240506, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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3
[SID124350076]
Potency 0.5799qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652016, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID124350076]
Potency 1.4631qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen [AID686947, Type: Literature]tyrosine-protein kinase Yes [Homo sapiens] [gi:4885661]
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5
[SID103457339]
GSK_PKIS: PRKG1 mean inhibition at 0.1 uM [Nanosyn] [AID651062, Type: other]cGMP-dependent protein kinase 1 [gi:6225588]
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6
[SID103457339]
GSK_PKIS: PRKG1 mean inhibition at 1 uM [Nanosyn] [AID651063, Type: other]cGMP-dependent protein kinase 1 [gi:6225588]
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7
[SID103457339]
GSK_PKIS: PRKG2 mean inhibition at 0.1 uM [Nanosyn] [AID651064, Type: other]cGMP-dependent protein kinase 2 [gi:6226833]
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8
[SID103457339]
GSK_PKIS: PRKG2 mean inhibition at 1 uM [Nanosyn] [AID651065, Type: other]cGMP-dependent protein kinase 2 [gi:6226833]
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9
[SID103457339]
GSK_PKIS: CHEK2 mean inhibition at 0.1 uM [Nanosyn] [AID651106, Type: other]Serine/threonine-protein kinase Chk2 [gi:6685284]
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10
[SID103457339]
GSK_PKIS: CHEK2 mean inhibition at 1 uM [Nanosyn] [AID651107, Type: other]Serine/threonine-protein kinase Chk2 [gi:6685284]
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11
[SID103457339]
GSK_PKIS: P38delta mean inhibition at 0.1 uM [Nanosyn] [AID651206, Type: other]Mitogen-activated protein kinase 13 [gi:6685642]
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12
[SID103457339]
GSK_PKIS: P38delta mean inhibition at 1 uM [Nanosyn] [AID651207, Type: other]Mitogen-activated protein kinase 13 [gi:6685642]
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13
[SID103457339]
GSK_PKIS: BRK mean inhibition at 0.1 uM [Nanosyn] [AID651394, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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14
[SID103457339]
GSK_PKIS: BRK mean inhibition at 1 uM [Nanosyn] [AID651395, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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15
[SID103457339]
GSK_PKIS: CDK3/cyclinE mean inhibition at 0.1 uM [Nanosyn] [AID651168, Type: other]Cyclin-dependent kinase 3 [gi:231726]
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16
[SID103457339]
GSK_PKIS: CDK3/cyclinE mean inhibition at 1 uM [Nanosyn] [AID651169, Type: other]Cyclin-dependent kinase 3 [gi:231726]
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17
[SID103457339]
GSK_PKIS: MAPK3 mean inhibition at 0.1 uM [Nanosyn] [AID651198, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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18
[SID103457339]
GSK_PKIS: MAPK3 mean inhibition at 1 uM [Nanosyn] [AID651199, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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19
[SID103457339]
GSK_PKIS: CDK6/cyclinD3 mean inhibition at 0.1 uM [Nanosyn] [AID651174, Type: other]Cyclin-dependent kinase 6 [gi:266423]
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20
[SID103457339]
GSK_PKIS: CDK6/cyclinD3 mean inhibition at 1 uM [Nanosyn] [AID651175, Type: other]Cyclin-dependent kinase 6 [gi:266423]
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21
[SID103457339]
GSK_PKIS: MEK1 mean inhibition at 0.1 uM [Nanosyn] [AID651350, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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22
[SID103457339]
GSK_PKIS: MEK1 mean inhibition at 1 uM [Nanosyn] [AID651351, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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23
[SID103457339]
GSK_PKIS: PIP5K1 (Caliper assay) % inhibition at 5 uM [UNC Frye lab] [AID651545, Type: other]
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24
[SID103457339]
GSK_PKIS: CDK2/cyclinA mean inhibition at 0.1 uM [Nanosyn] [AID651164, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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25
[SID103457339]
GSK_PKIS: CDK2/cyclinA mean inhibition at 1 uM [Nanosyn] [AID651165, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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26
[SID103457339]
GSK_PKIS: CDK2/cyclinE mean inhibition at 0.1 uM [Nanosyn] [AID651166, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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27
[SID103457339]
GSK_PKIS: CDK2/cyclinE mean inhibition at 1 uM [Nanosyn] [AID651167, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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28
[SID103457339]
GSK_PKIS: ERBB2 mean inhibition at 0.1 uM [Nanosyn] [AID651424, Type: other]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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29
[SID103457339]
GSK_PKIS: ERBB2 mean inhibition at 1 uM [Nanosyn] [AID651425, Type: other]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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30
[SID103457339]
GSK_PKIS: MAPK1 mean inhibition at 0.1 uM [Nanosyn] [AID651196, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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31
[SID103457339]
GSK_PKIS: MAPK1 mean inhibition at 1 uM [Nanosyn] [AID651197, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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32
[SID103457339]
GSK_PKIS: FGFR1 mean inhibition at 0.1 uM [Nanosyn] [AID651432, Type: other]Fibroblast growth factor receptor 1 [gi:120046]
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33
[SID103457339]
GSK_PKIS: FGFR1 mean inhibition at 1 uM [Nanosyn] [AID651433, Type: other]Fibroblast growth factor receptor 1 [gi:120046]
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34
[SID103457339]
GSK_PKIS: FGFR2 mean inhibition at 0.1 uM [Nanosyn] [AID651434, Type: other]Fibroblast growth factor receptor 2 [gi:120049]
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35
[SID103457339]
GSK_PKIS: FGFR2 mean inhibition at 1 uM [Nanosyn] [AID651435, Type: other]Fibroblast growth factor receptor 2 [gi:120049]
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36
[SID103457339]
GSK_PKIS: FGFR3 mean inhibition at 0.1 uM [Nanosyn] [AID651436, Type: other]Fibroblast growth factor receptor 3 [gi:120050]
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37
[SID103457339]
GSK_PKIS: FGFR3 mean inhibition at 1 uM [Nanosyn] [AID651437, Type: other]Fibroblast growth factor receptor 3 [gi:120050]
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38
[SID103457339]
GSK_PKIS: IGF1R mean inhibition at 0.1 uM [Nanosyn] [AID651252, Type: other]Insulin-like growth factor 1 receptor [gi:124240]
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39
[SID103457339]
GSK_PKIS: IGF1R mean inhibition at 1 uM [Nanosyn] [AID651253, Type: other]Insulin-like growth factor 1 receptor [gi:124240]
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40
[SID103457339]
GSK_PKIS: PKA mean inhibition at 0.1 uM [Nanosyn] [AID651040, Type: other]cAMP-dependent protein kinase catalytic subunit alpha [gi:125205]
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41
[SID103457339]
GSK_PKIS: PKA mean inhibition at 1 uM [Nanosyn] [AID651041, Type: other]cAMP-dependent protein kinase catalytic subunit alpha [gi:125205]
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42
[SID103457339]
GSK_PKIS: FGR mean inhibition at 0.1 uM [Nanosyn] [AID651440, Type: other]Tyrosine-protein kinase Fgr [gi:125358]
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43
[SID103457339]
GSK_PKIS: FGR mean inhibition at 1 uM [Nanosyn] [AID651441, Type: other]Tyrosine-protein kinase Fgr [gi:125358]
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44
[SID103457339]
GSK_PKIS: FYN mean inhibition at 0.1 uM [Nanosyn] [AID651248, Type: other]Tyrosine-protein kinase Fyn [gi:125370]
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45
[SID103457339]
GSK_PKIS: FYN mean inhibition at 1 uM [Nanosyn] [AID651249, Type: other]Tyrosine-protein kinase Fyn [gi:125370]
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46
[SID103457339]
GSK_PKIS: KIT mean inhibition at 0.1 uM [Nanosyn] [AID651268, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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47
[SID103457339]
GSK_PKIS: KIT mean inhibition at 1 uM [Nanosyn] [AID651269, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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48
[SID103457339]
GSK_PKIS: KIT (D816V mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651270, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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49
[SID103457339]
GSK_PKIS: KIT (D816V mutant) mean inhibition at 1 uM [Nanosyn] [AID651271, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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50
[SID103457339]
GSK_PKIS: KIT (T6701 mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651272, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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