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Tyrphostin AG 537 (CID 5329255) - Compound BioActivity Data
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BioActivity Outcomes:
Active(58)
 
 
Inactive(164)
 
 
Inconclusive(51)
 
 
Unspecified(2)
 
 
Top Targets:
p450(9)
 
 
 
7TM GPCR Srx(7)
 
 
 
HELICc(6)
 
 
 
PLN02808(5)
 
 
Pyr redox dim(5)
 
 
BioAssay Types:
Confirmatory(211)
 
 
 
 
 
Screening(26)
 
 
 
Literature(22)
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(187)
 
 
 
 
 
IC50(14)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 249    Data Row: 275   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50107068]
Potency 0.1122qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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2
[SID50107068]
Potency 0.1122qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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3
[SID50107068]
Potency 0.1259qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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4
[SID90341804]
Potency 0.2993qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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5
[SID85231261]
Potency 0.3162qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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6
[SID50107068]
Potency 0.3981qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID103259452]
IC50 0.4Inhibition of epidermal growth factor receptor (EGFR) phosphorylation of the exogenous substrate poly(Glu6, Ala3,Tyr) (polyGAT) [AID69399, Type: Literature]
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8
[SID50107068]
Potency 0.4467qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2353, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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9
[SID50107068]
Potency 0.4467qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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10
[SID11111892]
Potency 0.5133Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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11
[SID50107068]
Potency 0.631qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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12
[SID90341804]
Potency 0.6702qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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13
[SID90341804]
Potency 0.6702qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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14
[SID90341804]
Potency 0.8492qHTS Validation Assay to Find Inhibitors of Pin1 [AID504536, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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15
[SID103259452]
IC50 1.58489Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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16
[SID103259452]
IC50 1.58489Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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17
[SID90341804]
Potency 1.6834qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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18
[SID103259452]
IC50 1.7Inhibition of sheep brain dynamin 1 by malachite green GTPase assay [AID480340, Type: Literature]
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19
[SID103259452]
IC50 1.7Inhibitory activity against dynamin1 GTPase expressed in sheep brain [AID257178, Type: Literature]
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20
[SID90341804]
Potency 1.9012qHTS Validation Assay to Find Inhibitors of Phosphoglycerate Kinase [AID504547, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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21
[SID11111892]
Potency 1.9953qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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22
[SID50107068]
Potency 1.9953qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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23
[SID90341804]
Potency 2.1192qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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24
[SID50107068]
Potency 2.2387qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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25
[SID50107068]
Potency 2.2387qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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26
[SID50107068]
Potency 2.2387qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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27
[SID50107068]
Potency 2.2387qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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28
[SID103259452]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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29
[SID103259452]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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30
[SID103259452]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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31
[SID103259452]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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32
[SID50107068]
Potency 2.8184qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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33
[SID103259452]
IC50 3Antiproliferative activity determined by measuring the ability to block [3H]- thymidine uptake in HER-14 cells stimulated by EGF [AID81572, Type: Literature]
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34
[SID103259452]
IC50 3Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer [AID91426, Type: Literature]Integrase [gi:82312013]
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35
[SID103259452]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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36
[SID50107068]
Potency 3.1623qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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37
[SID11111892]
Potency 3.1623qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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38
[SID103259452]
IC50 3.3Inhibitory activity of compound against Epidermal growth factor receptor autophosphorylation [AID69406, Type: Literature]
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39
[SID50107068]
Potency 3.5481qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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40
[SID90341804]
Potency 3.7686qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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41
[SID85231261]
Potency 8.2753Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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42
[SID50107068]
Potency 10qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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43
[SID103259452]
IC50 10Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing [AID91425, Type: Literature]Integrase [gi:82312013]
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44
[SID85231261]
Potency 10.4179Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID488752, Type: confirmatory]
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45
[SID50107068]
Potency 15.8489qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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46
[SID11111892]
Potency 15.8489qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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47
[SID11111892]
Potency 15.8489qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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48
[SID90341804]
Potency 21.1923qHTS Validation Assay for the Inhibitors of DNA Replication in Gram-Positive Bacteria [AID485295, Type: confirmatory]DNA polymerase III [Bacillus subtilis] [gi:30027657]
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49
[SID11111892]
Potency 27.091qHTS Confirmation Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2585, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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50
[SID90341804]
Potency 36.8977qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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