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Tyrphostin AG 537 (CID 5329255) - Compound BioActivity Data
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BioActivity Outcomes:
Active(58)
 
 
Inactive(166)
 
 
Inconclusive(51)
 
 
Unspecified(2)
 
 
Top Targets:
p450(9)
 
 
 
7tm 4(8)
 
 
 
HELICc(6)
 
 
 
Pyr redox dim(5)
 
 
GH27(5)
 
 
BioAssay Types:
Confirmatory(212)
 
 
 
 
 
Screening(28)
 
 
 
Literature(21)
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(189)
 
 
 
 
 
IC50(14)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 250    Data Row: 277   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50107068]
Potency 0.1122qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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2
[SID50107068]
Potency 0.1122qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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3
[SID50107068]
Potency 0.1259qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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4
[SID90341804]
Potency 0.2993qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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5
[SID85231261]
Potency 0.3162qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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6
[SID50107068]
Potency 0.3981qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID103259452]
IC50 0.4Inhibition of epidermal growth factor receptor (EGFR) phosphorylation of the exogenous substrate poly(Glu6, Ala3,Tyr) (polyGAT) [AID69399, Type: Literature]
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8
[SID50107068]
Potency 0.4467qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2353, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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9
[SID50107068]
Potency 0.4467qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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10
[SID11111892]
Potency 0.5133Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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11
[SID50107068]
Potency 0.631qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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12
[SID90341804]
Potency 0.6702qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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13
[SID90341804]
Potency 0.6702qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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14
[SID90341804]
Potency 0.8492qHTS Validation Assay to Find Inhibitors of Pin1 [AID504536, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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15
[SID103259452]
IC50 1.58489Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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16
[SID103259452]
IC50 1.58489Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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17
[SID90341804]
Potency 1.6834qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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18
[SID103259452]
IC50 1.7Inhibitory activity against dynamin1 GTPase expressed in sheep brain [AID257178, Type: Literature]
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19
[SID103259452]
IC50 1.7Inhibition of sheep brain dynamin 1 by malachite green GTPase assay [AID480340, Type: Literature]
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20
[SID90341804]
Potency 1.9012qHTS Validation Assay to Find Inhibitors of Phosphoglycerate Kinase [AID504547, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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