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sunitinib (CID 5329102) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(1360)
 
 
Inactive(294)
 
 
Inconclusive(39)
 
 
Unspecified(1176)
 
 
Top Targets:
PKc(121)
 
 
 
 
PKc like(94)
 
 
 
 
STKc AGC(56)
 
 
 
PTKc Abl(43)
 
 
 
 
PTKc VEGFR2(32)
 
 
 
 
BioAssay Types:
Literature(2269)
 
 
 
 
 
Confirmatory(233)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Kd(1322)
 
 
 
 
IC50(547)
 
 
 
 
Potency(33)
 
 
 
 
Ki(6)
 
 
 
EC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2601    Data Row: 2869   Total Pages: 58   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103175813]
IC50 1.64e-06SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: other]
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2
[SID103175813]
Kd 7.5e-05Binding affinity to PDGFRB [AID507666, Type: Literature]
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3
[SID103175813]
Kd 7.5e-05Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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4
[SID103175813]
Kd 7.5e-05Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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5
[SID103175813]
Kd 0.00021Average Binding Constant for PDGFRB ; NA=Not Active at 10 uM [AID256661, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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6
[SID103175813]
Kd 0.00021Binding constant for KIT(V559D,V654A) kinase domain [AID435802, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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7
[SID103175813]
Kd 0.00021Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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8
[SID103175813]
Kd 0.00021Binding affinity to KIT V559D,V654A mutant [AID507584, Type: Literature]
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9
[SID103175813]
Kd 0.00022Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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10
[SID103175813]
Kd 0.00022Binding affinity to FLT3 K663Q mutant [AID507956, Type: Literature]
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11
[SID103175813]
Kd 0.00023Average Binding Constant for VEGFR2 ; NA=Not Active at 10 uM [AID256642, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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12
[SID103175813]
IC50 0.000272SANGER: Inhibition of human MV-4-11 cell growth in a cell viability assay. [AID742380, Type: other]
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13
[SID103175813]
Kd 0.00028Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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14
[SID103175813]
Kd 0.00028Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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15
[SID103175813]
Kd 0.00028Binding affinity to KIT V559D,T670I mutant [AID507583, Type: Literature]
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16
[SID103175813]
Kd 0.00037Binding affinity to KIT [AID507579, Type: Literature]
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17
[SID103175813]
Kd 0.00037Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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18
[SID103175813]
Kd 0.00037Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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19
[SID103175813]
Kd 0.00037Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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20
[SID103175813]
Kd 0.00041Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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21
[SID103175813]
Kd 0.00041Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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22
[SID103175813]
Kd 0.00041Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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23
[SID103175813]
Kd 0.00041Binding affinity to KIT V559D mutant [AID507582, Type: Literature]
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24
[SID103175813]
Kd 0.00047Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assay [AID438342, Type: Literature]
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25
[SID103175813]
Kd 0.00047Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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26
[SID103175813]
Kd 0.00047Binding affinity to FLT3 [AID507952, Type: Literature]
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27
[SID103175813]
Kd 0.00047Binding affinity to FLT3 catalytic domain by KinomeScan kinase binding assay [AID507803, Type: Literature]
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28
[SID103175813]
Kd 0.0007Inhibition of Kit [AID383082, Type: Literature]
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29
[SID103175813]
Kd 0.00071Average Binding Constant for KIT ; NA=Not Active at 10 uM [AID256660, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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30
[SID103175813]
Kd 0.00079Binding constant for PDGFRA kinase domain [AID435827, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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31
[SID103175813]
Kd 0.00079Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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32
[SID103175813]
Kd 0.00079Binding affinity to PDGFRA [AID507665, Type: Literature]
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33
[SID103175813]
Kd 0.0008Average Binding Constant for FLT3 ; NA=Not Active at 10 uM [AID256620, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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34
[SID103175813]
Kd 0.00099Binding constant for FLT3(ITD) kinase domain [AID435310, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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35
[SID103175813]
Kd 0.00099Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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36
[SID103175813]
Kd 0.00099Binding affinity to FLT3 ITD mutant [AID507955, Type: Literature]
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37
[SID103175813]
Kd 0.001Binding affinity to DRAK1 [AID507903, Type: Literature]
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38
[SID103175813]
IC50 0.001Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assay [AID684153, Type: Literature]
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39
[SID103175813]
Kd 0.001Binding constant for DRAK1 kinase domain [AID435790, Type: Literature]Serine/threonine-protein kinase 17A [gi:317373279]
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40
[SID103175813]
Kd 0.001Binding constant for DRAK1 kinase domain [AID624968, Type: Literature]Serine/threonine-protein kinase 17A [gi:317373279]
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41
[SID103175813]
IC50 0.001Inhibition of recombinant Ret by radioactive phosphotransfer assay in presence of 10 uM ATP [AID507422, Type: Literature]
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42
[SID103175813]
IC50 0.001Inhibition of recombinant PDGFR by radioactive phosphotransfer assay in presence of 10 uM ATP [AID507424, Type: Literature]
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43
[SID103175813]
IC50 0.001Inhibition of recombinant CK1 by radioactive phosphotransfer assay in presence of 10 uM ATP [AID507421, Type: Literature]
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44
[SID103175813]
Kd 0.0013Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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45
[SID103175813]
Kd 0.0015Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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46
[SID103175813]
Kd 0.0015Binding constant for VEGFR2 kinase domain [AID435327, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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47
[SID103175813]
Kd 0.0015Binding affinity to VEGFR2 [AID508129, Type: Literature]
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48
[SID103175813]
Kd 0.0018Binding affinity to FLT1 [AID507951, Type: Literature]
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49
[SID103175813]
Kd 0.0018Binding constant for FLT1 kinase domain [AID435429, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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50
[SID103175813]
Kd 0.0018Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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