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sunitinib (CID 5329102) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1393)
 
 
Inactive(295)
 
 
Inconclusive(39)
 
 
Unspecified(1180)
 
 
Top Targets:
PKc(121)
 
 
 
 
PKc like(94)
 
 
 
 
STKc AGC(56)
 
 
 
PTKc Abl(44)
 
 
 
 
PTKc VEGFR2(34)
 
 
 
 
BioAssay Types:
Literature(2298)
 
 
 
 
 
Confirmatory(600)
 
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Kd(1322)
 
 
 
 
IC50(576)
 
 
 
 
Potency(34)
 
 
 
 
Ki(6)
 
 
 
EC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2639    Data Row: 2907   Total Pages: 146   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103175813]
IC50 1.64e-06SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: confirmatory]
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2
[SID103175813]
Kd 7.5e-05Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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3
[SID103175813]
Kd 7.5e-05Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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4
[SID103175813]
Kd 7.5e-05Binding affinity to PDGFRB [AID507666, Type: Literature]
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5
[SID103175813]
Kd 0.00021Binding affinity to KIT V559D,V654A mutant [AID507584, Type: Literature]
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6
[SID103175813]
Kd 0.00021Average Binding Constant for PDGFRB; NA=Not Active at 10 uM [AID256661, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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7
[SID103175813]
Kd 0.00021Binding constant for KIT(V559D,V654A) kinase domain [AID435802, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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8
[SID103175813]
Kd 0.00021Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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9
[SID103175813]
Kd 0.00022Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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10
[SID103175813]
Kd 0.00022Binding affinity to FLT3 K663Q mutant [AID507956, Type: Literature]
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11
[SID103175813]
Kd 0.00023Average Binding Constant for VEGFR2; NA=Not Active at 10 uM [AID256642, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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12
[SID103175813]
IC50 0.000272SANGER: Inhibition of human MV-4-11 cell growth in a cell viability assay. [AID742380, Type: confirmatory]
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13
[SID103175813]
Kd 0.00028Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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14
[SID103175813]
Kd 0.00028Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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15
[SID103175813]
Kd 0.00028Binding affinity to KIT V559D,T670I mutant [AID507583, Type: Literature]
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16
[SID103175813]
Kd 0.00037Binding affinity to KIT [AID507579, Type: Literature]
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17
[SID103175813]
Kd 0.00037Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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18
[SID103175813]
Kd 0.00037Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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19
[SID103175813]
Kd 0.00037Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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20
[SID103175813]
Kd 0.00041Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View