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bosutinib (CID 5328940) - Compound BioActivity Data
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BioActivity Outcomes:
Active(742)
 
 
Inactive(35)
 
 
Inconclusive(2)
 
 
Unspecified(417)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
PTKc Abl(21)
 
 
PTKc Src like(19)
 
 
STKc AGC(17)
 
 
 
BioAssay Types:
Literature(600)
 
 
 
 
Confirmatory(12)
 
 
 
Screening(1)
 
 
BioActivity Types:
IC50(688)
 
 
 
Kd(442)
 
 
 
Potency(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1186    Data Row: 1196   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103220856]
Kd 2.9e-05Binding constant for ABL1(F317L)-phosphorylated kinase domain [AID624982, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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2
[SID103220856]
Kd 3.6e-05Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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3
[SID103220856]
Kd 3.7e-05Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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4
[SID103220856]
Kd 3.9e-05Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
5
[SID103220856]
Kd 4.7e-05Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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6
[SID103220856]
Kd 5.7e-05Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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7
[SID103220856]
Kd 5.7e-05Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
8
[SID103220856]
Kd 6.2e-05Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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9
[SID103220856]
Kd 8.6e-05Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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10
[SID103220856]
Kd 0.00011Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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11
[SID103220856]
Kd 0.00012Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
12
[SID103220856]
Kd 0.00018Binding constant for ABL1(F317I)-phosphorylated kinase domain [AID624980, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103220856]
IC50 0.0003Inhibition of MAP4K5 [AID507427, Type: Literature]
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14
[SID103220856]
IC50 0.0004Inhibition of YES1 [AID507428, Type: Literature]
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15
[SID103220856]
IC50 0.0005Inhibition of ABL1 [AID507429, Type: Literature]
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16
[SID103220856]
IC50 0.0005Inhibition of ABL2 [AID507431, Type: Literature]
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17
[SID103220856]
Kd 0.0005Binding constant for MAP4K5 kinase domain [AID625061, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 5 [gi:30316147]
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18
[SID103220856]
Kd 0.00059Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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19
[SID103220856]
Kd 0.00063Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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20
[SID103220856]
Kd 0.00077Binding constant for ERBB3 kinase domain [AID624851, Type: Literature]Receptor tyrosine-protein kinase erbB-3 [gi:119534]
View
21
[SID103220856]
Kd 0.001Binding constant for SRC kinase domain [AID625016, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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22
[SID103220856]
IC50 0.001Inhibitory activity against Abl kinase [AID255763, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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23
[SID103220856]
IC50 0.001Inhibitory activity against Abl kinase [AID255763, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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24
[SID103220856]
IC50 0.001Inhibition of SRC [AID507432, Type: Literature]
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25
[SID103220856]
IC50 0.001Inhibition of c-SRC [AID592838, Type: Literature]
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26
[SID103220856]
IC50 0.0011Inhibition of FGR [AID507433, Type: Literature]
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27
[SID103220856]
IC50 0.0011Inhibition of wild type Abl [AID463625, Type: Literature]
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28
[SID103220856]
IC50 0.0011Inhibitory concentration against v-Abl tyrosine kinase [AID254706, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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29
[SID103220856]
IC50 0.0011Inhibition of Abl kinase [AID32559, Type: Literature]
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30
[SID103220856]
IC50 0.0011Inhibition of v-Abl tyrosine kinase [AID240522, Type: Literature]
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31
[SID103220856]
IC50 0.0012Inhibition of Src kinase in yeast-based screen [AID205321, Type: Literature]
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32
[SID103220856]
IC50 0.0012Inhibition of Src protein tryrosine kinase [AID205351, Type: Literature]
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33
[SID103220856]
IC50 0.0012Inhibition against Src kinase [AID219519, Type: Literature]
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34
[SID103220856]
IC50 0.0012Inhibition of Src protein tryrosine kinase [AID205331, Type: Literature]
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35
[SID103220856]
IC50 0.0012Inhibitory concentration against Src kinase [AID254888, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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36
[SID103220856]
IC50 0.0012Inhibition of human recombinant cSrc by ELISA [AID408487, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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37
[SID103220856]
IC50 0.0012Inhibition of Src kinase [AID415071, Type: Literature]
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38
[SID103220856]
IC50 0.0012Inhibition of cSrc by ELISA [AID344881, Type: Literature]
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39
[SID103220856]
IC50 0.0013Inhibition of LCK [AID507434, Type: Literature]
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40
[SID103220856]
Kd 0.0013Binding constant for GAK kinase domain [AID625012, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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41
[SID103220856]
IC50 0.0013Inhibitory concentration against Src protein tryrosine kinase [AID205349, Type: Literature]
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42
[SID103220856]
Kd 0.0014Binding constant for FRK kinase domain [AID624855, Type: Literature]Tyrosine-protein kinase FRK [gi:1169745]
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43
[SID103220856]
Kd 0.0015Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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44
[SID103220856]
IC50 0.0018Inhibition of FYN [AID507435, Type: Literature]
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45
[SID103220856]
IC50 0.0018Inhibition of cSrc [AID344880, Type: Literature]
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46
[SID103220856]
Kd 0.002Binding constant for STK35 kinase domain [AID624711, Type: Literature]Serine/threonine-protein kinase 35 [gi:292495039]
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47
[SID103220856]
IC50 0.0022Inhibition of FRK [AID507436, Type: Literature]
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48
[SID103220856]
IC50 0.0025Inhibition of BTK [AID507437, Type: Literature]
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49
[SID103220856]
IC50 0.0027Inhibition of TNK2 [AID507438, Type: Literature]
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50
[SID103220856]
Kd 0.0031Binding constant for MAP4K2 kinase domain [AID624959, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 2 [gi:215274019]
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