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bosutinib (CID 5328940) - Compound BioActivity Data
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BioActivity Outcomes:
Active(742)
 
 
Inactive(35)
 
 
Inconclusive(2)
 
 
Unspecified(417)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
PTKc Abl(21)
 
 
PTKc Src like(19)
 
 
STKc AGC(17)
 
 
 
BioAssay Types:
Literature(600)
 
 
 
 
Confirmatory(587)
 
 
 
 
 
Screening(1)
 
 
BioActivity Types:
IC50(688)
 
 
 
Kd(442)
 
 
 
Potency(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1186    Data Row: 1196   Total Pages: 60   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103220856]
Kd 2.9e-05Binding constant for ABL1(F317L)-phosphorylated kinase domain [AID624982, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
2
[SID103220856]
Kd 3.6e-05Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
3
[SID103220856]
Kd 3.7e-05Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
4
[SID103220856]
Kd 3.9e-05Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
5
[SID103220856]
Kd 4.7e-05Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
6
[SID103220856]
Kd 5.7e-05Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
7
[SID103220856]
Kd 5.7e-05Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
8
[SID103220856]
Kd 6.2e-05Binding constant for ABL1(H396P)-non phosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
9
[SID103220856]
Kd 8.6e-05Binding constant for ABL1(Q252H)-non phosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
10
[SID103220856]
Kd 0.00011Binding constant for ABL1(F317L)-non phosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
11
[SID103220856]
Kd 0.00012Binding constant for ABL1-non phosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
12
[SID103220856]
Kd 0.00018Binding constant for ABL1(F317I)-phosphorylated kinase domain [AID624980, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
13
[SID103220856]
IC50 0.0003Inhibition of MAP4K5 [AID507427, Type: Literature]
View
14
[SID103220856]
IC50 0.0004Inhibition of YES1 [AID507428, Type: Literature]
View
15
[SID103220856]
IC50 0.0005Inhibition of ABL1 [AID507429, Type: Literature]
View
16
[SID103220856]
IC50 0.0005Inhibition of ABL2 [AID507431, Type: Literature]
View
17
[SID103220856]
Kd 0.0005Binding constant for MAP4K5 kinase domain [AID625061, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 5 [gi:30316147]
View
18
[SID103220856]
Kd 0.00059Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
View
19
[SID103220856]
Kd 0.00063Binding constant for ABL1(F317I)-non phosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
20
[SID103220856]
Kd 0.00077Binding constant for ERBB3 kinase domain [AID624851, Type: Literature]Receptor tyrosine-protein kinase erbB-3 [gi:119534]
View