bosutinib (CID 5328940) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(347)
 
 
Inactive(31)
 
 
Inconclusive(2)
 
 
Unspecified(226)
 
 
Top Targets:
PKc(55)
 
 
 
PKc like(35)
 
 
 
STKc AGC(24)
 
 
 
PTKc Abl(19)
 
 
PTKc Src like(16)
 
 
BioAssay Types:
Literature(592)
 
 
 
 
Confirmatory(8)
 
 
 
Screening(1)
 
 
BioActivity Types:
Kd(442)
 
 
 
IC50(106)
 
 
 
Potency(8)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 603    Data Row: 606   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103220856]
Kd 2.9e-05Binding constant for ABL1(F317L)-phosphorylated kinase domain [AID624982, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
2
[SID103220856]
Kd 2.9e-05Binding constant for ABL1(F317L)-phosphorylated kinase domain [AID624982, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
3
[SID103220856]
Kd 3.6e-05Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
4
[SID103220856]
Kd 3.6e-05Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
5
[SID103220856]
Kd 3.7e-05Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
6
[SID103220856]
Kd 3.7e-05Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
7
[SID103220856]
Kd 3.9e-05Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
8
[SID103220856]
Kd 3.9e-05Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
9
[SID103220856]
Kd 4.7e-05Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
10
[SID103220856]
Kd 4.7e-05Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
11
[SID103220856]
Kd 5.7e-05Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
12
[SID103220856]
Kd 5.7e-05Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
13
[SID103220856]
Kd 5.7e-05Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
14
[SID103220856]
Kd 5.7e-05Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
15
[SID103220856]
Kd 6.2e-05Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
16
[SID103220856]
Kd 6.2e-05Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
17
[SID103220856]
Kd 8.6e-05Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
18
[SID103220856]
Kd 8.6e-05Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
19
[SID103220856]
Kd 0.00011Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
20
[SID103220856]
Kd 0.00011Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
21
[SID103220856]
Kd 0.00012Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
22
[SID103220856]
Kd 0.00012Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
23
[SID103220856]
Kd 0.00018Binding constant for ABL1(F317I)-phosphorylated kinase domain [AID624980, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
24
[SID103220856]
Kd 0.00018Binding constant for ABL1(F317I)-phosphorylated kinase domain [AID624980, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
25
[SID103220856]
IC50 0.0003Inhibition of MAP4K5 [AID507427, Type: Literature]
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26
[SID103220856]
IC50 0.0004Inhibition of YES1 [AID507428, Type: Literature]
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27
[SID103220856]
IC50 0.0005Inhibition of ABL1 [AID507429, Type: Literature]
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28
[SID103220856]
IC50 0.0005Inhibition of ABL2 [AID507431, Type: Literature]
View
29
[SID103220856]
Kd 0.0005Binding constant for MAP4K5 kinase domain [AID625061, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 5 [gi:30316147]
View
30
[SID103220856]
Kd 0.0005Binding constant for MAP4K5 kinase domain [AID625061, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 5 [gi:30316147]
View
31
[SID103220856]
Kd 0.00059Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
View
32
[SID103220856]
Kd 0.00059Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
View
33
[SID103220856]
Kd 0.00063Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
34
[SID103220856]
Kd 0.00063Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
35
[SID103220856]
Kd 0.00077Binding constant for ERBB3 kinase domain [AID624851, Type: Literature]Receptor tyrosine-protein kinase erbB-3 [gi:119534]
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36
[SID103220856]
IC50 0.001Inhibition of c-SRC [AID592838, Type: Literature]
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37
[SID103220856]
IC50 0.001Inhibition of SRC [AID507432, Type: Literature]
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38
[SID103220856]
IC50 0.001Inhibitory activity against Abl kinase [AID255763, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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39
[SID103220856]
IC50 0.001Inhibitory activity against Abl kinase [AID255763, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
40
[SID103220856]
Kd 0.001Binding constant for SRC kinase domain [AID625016, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
View
41
[SID103220856]
Kd 0.001Binding constant for SRC kinase domain [AID625016, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
View
42
[SID103220856]
IC50 0.0011Inhibition of FGR [AID507433, Type: Literature]
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43
[SID103220856]
IC50 0.0011Inhibition of v-Abl tyrosine kinase [AID240522, Type: Literature]
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44
[SID103220856]
IC50 0.0011Inhibition of Abl kinase [AID32559, Type: Literature]
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45
[SID103220856]
IC50 0.0011Inhibition of wild type Abl [AID463625, Type: Literature]
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46
[SID103220856]
IC50 0.0011Inhibitory concentration against v-Abl tyrosine kinase [AID254706, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
47
[SID103220856]
IC50 0.0011Inhibitory concentration against v-Abl tyrosine kinase [AID254706, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
48
[SID103220856]
IC50 0.0012Inhibition of Src kinase [AID415071, Type: Literature]
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49
[SID103220856]
IC50 0.0012Inhibition of cSrc by ELISA [AID344881, Type: Literature]
View
50
[SID103220856]
IC50 0.0012Inhibition of Src protein tryrosine kinase [AID205351, Type: Literature]
View