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AG 538 (CID 5328760) - Compound BioActivity Data
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BioActivity Outcomes:
Active(133)
 
 
Inactive(557)
 
 
Inconclusive(86)
 
 
Unspecified(6)
 
 
Top Targets:
7tm 4(43)
 
 
 
 
alkPPc(17)
 
 
 
p450(9)
 
 
 
 
Pyr redox dim(8)
 
 
 
ANK(8)
 
 
 
BioAssay Types:
Screening(364)
 
 
 
Confirmatory(343)
 
 
 
 
 
Literature(52)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(290)
 
 
 
 
 
IC50(43)
 
 
 
 
 
EC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 690    Data Row: 782   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103244133]
IC50 0.061Inhibition of IGF1R [AID430645, Type: Literature]
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2
[SID50107211]
Potency 0.0631qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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3
[SID56463264]
Potency 0.0752qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation [AID540279, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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4
[SID56463264]
IC50 0.07955TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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5
[SID56463264]
IC50 0.07955TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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6
[SID56463264]
Potency 0.0947qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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7
[SID50107211]
Potency 0.1122qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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8
[SID50107211]
Potency 0.1259qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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9
[SID56463264]
Potency 0.1683qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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10
[SID50107211]
Potency 0.1995Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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11
[SID56463264]
IC50_Mean 0.259Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase [AID488874, Type: confirmatory]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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12
[SID50107211]
Potency 0.2818qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2353, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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13
[SID50107211]
Potency 0.2818qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID1705, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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14
[SID56463264]
Potency 0.3261qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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15
[SID90340715]
Potency 0.3359qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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16
[SID103244133]
IC50 0.37Inhibition of polyGAT phosphorylation [AID162571, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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17
[SID103244133]
IC50 0.37Inhibition of epidermal growth factor receptor (EGFR) phosphorylation of the exogenous substrate poly(Glu6, Ala3,Tyr) (polyGAT) [AID69399, Type: Literature]
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18
[SID56463264]
Potency 0.3769qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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19
[SID103244133]
IC50 0.4Inhibition of EGFR in human A431 cells [AID358171, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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20
[SID50107211]
Potency 0.5012qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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