Bookmark and Share
CHEMBL2431120 (CID 53245590) - Compound BioActivity Data
.
BioActivity Outcomes:
Probe(1)
 
 
Active(18)
 
 
Inactive(3)
 
 
Unspecified(36)
 
 
Top Targets:
7TM GPCR Srv(10)
 
 
 
 
 
7TM GPCR Srx(4)
 
 
 
7TM GPCR Srsx(3)
 
 
 
ERG2 Sigma1R(2)
 
 
 
Neur chan LBD(1)
 
 
BioAssay Types:
Literature(51)
 
 
 
Confirmatory(6)
 
 
 
Summary(1)
 
 
BioActivity Types:
EC50(10)
 
 
 
 
Ki(7)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 56    Data Row: 58   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134225039]
Summary Assay for Selective Agonists of NTR1 [AID493055, Type: summary]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
View
2
[SID174498737]
Ki 0.4Binding affinity to 5-HT1A receptor (unknown origin) [AID772296, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
View
3
[SID174498737]
Ki 0.41Binding affinity to sigma-1 receptor (unknown origin) [AID772290, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:74752153]
View
4
[SID174498737]
Ki 0.93Binding affinity to 5-HT7 receptor (unknown origin) [AID772294, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
View
5
[SID174498737]
Ki 1Binding affinity to 5-HT3 receptor (unknown origin) [AID772295, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168222]
View
6
[SID174498737]
Ki 1.42Binding affinity to histamine H1 receptor (unknown origin) [AID772293, Type: Literature]Histamine H1 receptor [gi:547645]
View
7
[SID174498737]
Ki 1.54Binding affinity to mu opioid receptor (unknown origin) [AID772292, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
8
[SID134225039]
EC50_Mean 1.89SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
View
9
[SID174498737]
EC50 2Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay [AID772307, Type: Literature]Neurotensin receptor type 1 [gi:62297312]
View
10
[SID124360477]
EC50_Mean 2.18SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
View
11
[SID174498737]
Ki 2.54Binding affinity to PBR receptor (unknown origin) [AID772291, Type: Literature]Translocator protein [gi:313104268]
View
12
[SID174498737]
EC50 3.41Agonist activity at NTR1 (unknown origin) expressed in CHOK1 cells by beta-arrestin assay [AID772301, Type: Literature]Neurotensin receptor type 1 [gi:62297312]
View
13
[SID124360477]
EC50_Mean 3.8SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
View
14
[SID174498737]
LC50 29.6Hepatotoxicity in human Fa2N-4 cells after 24 hrs by luminescence assay [AID772265, Type: Literature]
View
15
[SID174498737]
Kinetic solubility of the compound in pION buffer at 250 uM after 18 hrs at pH 7.4 [AID772278, Type: Literature]
View
16
[SID174498737]
Kinetic solubility of the compound in PBS buffer at 250 uM after 18 hrs at pH 7.4 [AID772279, Type: Literature]
View
17
[SID174498737]
Kinetic solubility of the compound in pION buffer at 250 uM after 18 hrs at pH 6.2 [AID772281, Type: Literature]
View
18
[SID174498737]
Antiviral activity against Hepatitis C virus assessed as growth inhibition [AID772288, Type: Literature]
View
19
[SID174498737]
Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition [AID772289, Type: Literature]
View
20
[SID174498737]
EC50 40Agonist activity at GPR35 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay [AID772304, Type: Literature]G-protein coupled receptor 35 [gi:68068087]
View