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Streptonigrin (CID 5323583) - Compound BioActivity Data
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BioActivity Outcomes:
Active(258)
 
 
Inactive(394)
 
 
Inconclusive(44)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(28)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(8)
 
 
G-alpha(7)
 
 
 
NR LBD PPAR(6)
 
 
BioAssay Types:
Confirmatory(352)
 
 
 
 
 
Screening(265)
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(162)
 
 
 
 
 
IC50(36)
 
 
 
 
EC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 576    Data Row: 698   Total Pages: 35   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID11532976]
Potency 0.0082qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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2
[SID11532976]
Potency 0.0092qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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3
[SID11532976]
IC50 0.0094Luminescence-based dose response cell-based high throughput screening assay for cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1972, Type: confirmatory]
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4
[SID11532976]
Potency 0.0125Secondary Assay for Inhibitors of Human Galactokinase (GALK): HEK-293 Cell Viability Assay [AID2547, Type: confirmatory]
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5
[SID11532976]
Potency 0.0185Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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6
[SID11532976]
Potency 0.0397qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1 [AID624249, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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7
[SID11532976]
Potency 0.0411qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID11532976]
Potency 0.0522Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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9
[SID11532976]
Potency 0.0561qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with MMS Viability [AID624251, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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10
[SID11532976]
Potency 0.058qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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11
[SID11532976]
Potency 0.0731Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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12
[SID11532976]
Potency 0.082qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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13
[SID11532976]
Potency 0.1032qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID11532976]
Potency 0.2818qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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15
[SID11532976]
Potency 0.3162qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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16
[SID11532976]
Average IC50 [PAD3] 0.43Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of streptonigrin against PAD1-3 [AID588462_3, Type: confirmatory]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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17
[SID11532976]
Potency 0.631qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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18
[SID11532976]
Potency 0.7079qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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19
[SID11532976]
Potency 0.7079qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia [AID485349, Type: confirmatory]serine-protein kinase ATM [Homo sapiens] [gi:71902540]
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20
[SID11532976]
Potency 0.8199qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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