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icariin (CID 5318997) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(369)
 
 
Inconclusive(6)
 
 
Unspecified(8)
 
 
Top Targets:
Bcl-2 like(12)
 
 
7TM GPCR Srx(11)
 
 
alkPPc(10)
 
 
NR LBD PPAR(6)
 
 
7TM GPCR Srsx(6)
 
 
BioAssay Types:
Screening(241)
 
 
 
Confirmatory(108)
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(58)
 
 
 
IC50(38)
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 348    Data Row: 384   Total Pages: 20   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as assessed as increase in intracellular adriamycin accumulation at 5 uM incubated 2 hrs before adriamycin challenge by spectrophotometry [AID428312, Type: Literature]
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2
[SID103693320]
IC50 100Cytotoxicity against human MCF7/ADR cells after 72 hrs by MTT assay [AID428308, Type: Literature]
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3
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as enhancement in cytotoxicity of adriamycin [AID428311, Type: Literature]
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4
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as modulation factor, ratio of adriamycin IC50 without drug to adriamycin IC50 with drug at 1 uM after 72 hrs by MTT assay [AID428314, Type: Literature]
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5
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as modulation factor, ratio of adriamycin IC50 without drug to adriamycin IC50 with drug at 10 uM after 72 hrs by MTT assay [AID428315, Type: Literature]
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6
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as modulation factor, ratio of adriamycin IC50 without drug to adriamycin IC50 with drug at 25 uM after 72 hrs by MTT assay [AID428316, Type: Literature]
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7
[SID103693320]
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977599, Type: Literature]
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8
[SID103693320]
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977602, Type: Literature]
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9
[SID103693320]
Inhibition of human PDE6C at 10 uM [AID362788, Type: Literature]Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [gi:90111861]
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10
[SID26719816]
Potency 12.5893qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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11
[SID49681687]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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12
[SID26719816]
uHTS for Calpain Inhibitors [AID1236, Type: screening]calpain II, partial [Sus scrofa] [gi:1628587]
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13
[SID26719816]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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14
[SID26719816]
Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1051, Type: other]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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15
[SID26719816]
Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1) [AID1424, Type: screening]transient receptor potential cation channel, subfamily N, member 1 [Danio rerio] [gi:34330186]
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16
[SID26719816]
IC50 Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP) [AID1445, Type: confirmatory]m1-family aminopeptidase [Plasmodium falciparum 3D7] [gi:124512980]
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17
[SID26719816]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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18
[SID49681687]
Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha [AID2650, Type: screening]glycogen synthase kinase-3 alpha [Homo sapiens] [gi:49574532]
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19
[SID49681687]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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20
[SID26719816]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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