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icariin (CID 5318997) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(369)
 
 
Inconclusive(6)
 
 
Unspecified(8)
 
 
Top Targets:
Bcl-2 like(12)
 
 
7TM GPCR Srx(11)
 
 
alkPPc(10)
 
 
NR LBD PPAR(6)
 
 
7TM GPCR Srsx(6)
 
 
BioAssay Types:
Screening(241)
 
 
 
Confirmatory(108)
 
 
 
Literature(16)
 
 
 
 
BioActivity Types:
Potency(58)
 
 
 
IC50(39)
 
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 349    Data Row: 385   Total Pages: 20   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103693320]
IC50 5.9Inhibition of human recombinant PDE5A1 expressed in COS7 cells [AID362785, Type: Literature]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:317373261]
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2
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as assessed as increase in intracellular adriamycin accumulation at 5 uM incubated 2 hrs before adriamycin challenge by spectrophotometry [AID428312, Type: Literature]
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3
[SID103693320]
IC50 100Cytotoxicity against human MCF7/ADR cells after 72 hrs by MTT assay [AID428308, Type: Literature]
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4
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as enhancement in cytotoxicity of adriamycin [AID428311, Type: Literature]
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5
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as modulation factor, ratio of adriamycin IC50 without drug to adriamycin IC50 with drug at 1 uM after 72 hrs by MTT assay [AID428314, Type: Literature]
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6
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as modulation factor, ratio of adriamycin IC50 without drug to adriamycin IC50 with drug at 10 uM after 72 hrs by MTT assay [AID428315, Type: Literature]
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7
[SID103693320]
Reversal of P-gp-mediated multidrug resistance in human MCF7/ADR cells assessed as modulation factor, ratio of adriamycin IC50 without drug to adriamycin IC50 with drug at 25 uM after 72 hrs by MTT assay [AID428316, Type: Literature]
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8
[SID103693320]
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977599, Type: Literature]
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9
[SID103693320]
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977602, Type: Literature]
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10
[SID103693320]
Inhibition of human PDE6C at 10 uM [AID362788, Type: Literature]Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [gi:90111861]
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11
[SID26719816]
Potency 12.5893qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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12
[SID26719816]
Potency qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID1466, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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13
[SID26719816]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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14
[SID26719816]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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15
[SID26719816]
Potency qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID2242, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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16
[SID26719816]
Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1446, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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17
[SID26719816]
Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1861, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
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18
[SID49681687]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) [AID434973, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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19
[SID26719816]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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20
[SID26719816]
Primary cell-based high throughput screening assay to identify inhibitors of kruppel-like factor 5 (KLF5) [AID1700, Type: screening]Kruppel-like factor 5 [Homo sapiens] [gi:124263658]
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