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Succinylcholine (CID 5314) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(203)
 
 
Inconclusive(7)
 
 
Unspecified(27)
 
 
Top Targets:
7tm 4(9)
 
 
 
p450(9)
 
 
Esterase lipa..(7)
 
 
Pyruvate Kina..(4)
 
 
HSD10-like SD..(4)
 
 
BioAssay Types:
Confirmatory(134)
 
 
 
Screening(58)
 
 
 
Literature(39)
 
 
 
 
BioActivity Types:
Potency(113)
 
 
 
Kd(4)
 
 
Ki(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 226    Data Row: 249   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194169]
ED50 0.54Dose causing 50% block of muscle twitch in isolated chick biventer cervicis muscle (Decrease in baseline tension) [AID219534, Type: Literature]
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2
[SID103194169]
Ki 21Inhibition of mouse AChE [AID404437, Type: Literature]Acetylcholinesterase [gi:113038]
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3
[SID53812664]
Kd 22Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491227]
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4
[SID53812664]
Kd 22Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491227]
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5
[SID103194169]
EC50 30Stimulation of ion flux in TE671 cells [AID208872, Type: Literature]
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6
[SID53812668]
Kd 48Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of Mutant S203a Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491239]
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7
[SID53812668]
Kd 48Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of Mutant S203a Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491239]
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8
[SID53812668]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Mutant S203a Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491239]
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9
[SID53812664]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491227]
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10
[SID85209629]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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11
[SID103194169]
Agonist efficacy was evaluated as concentration that produces 10-m V depolarization in frog sartorius muscle. [AID71786, Type: Literature]
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12
[SID124752895]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). [AID687014, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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13
[SID103194169]
Inhibitory potency in anesthetized rhesus monkeys [AID126469, Type: Literature]
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14
[SID103194169]
Duration (90%) measured for NMB activity in anesthetized rhesus monkeys [AID126970, Type: Literature]
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15
[SID103194169]
Onset time was measured for NMB activity in anesthetized rhesus monkeys [AID127134, Type: Literature]
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16
[SID103194169]
Recovery time (25-75 %) measured for NMB activity in anesthetized rhesus monkeys [AID127145, Type: Literature]
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17
[SID103194169]
Inhibition of superior cervical nerve-induced contractions of the nictitating membrane in anesthetized cats; Pre- and post-block increases in twitch tension and short-lived muscle fasciculations 20-30 s after dosing [AID219381, Type: Literature]
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18
[SID103194169]
ED50 Inhibitory potency in anesthetized cats [AID219382, Type: Literature]
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19
[SID103194169]
Inhibition of stimulated vagus nerve-induced bradycardia in anesthetized cats; ND means not data [AID219385, Type: Literature]
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20
[SID103194169]
Duration (90%) measured for NMB activity in anesthetized cats [AID219389, Type: Literature]
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