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Succinylcholine (CID 5314) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(201)
 
 
Inconclusive(7)
 
 
Unspecified(27)
 
 
Top Targets:
p450(9)
 
 
7TM GPCR Srx(6)
 
 
 
Pyr redox dim(4)
 
 
HSD10-like SD..(4)
 
 
PIKKc TOR(4)
 
 
BioAssay Types:
Confirmatory(133)
 
 
 
Screening(57)
 
 
 
Literature(35)
 
 
 
 
BioActivity Types:
Potency(112)
 
 
 
Ki(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 223    Data Row: 243   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194169]
ED50 0.54Dose causing 50% block of muscle twitch in isolated chick biventer cervicis muscle (Decrease in baseline tension) [AID219534, Type: Literature]
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2
[SID103194169]
Ki 21Inhibition of mouse AChE [AID404437, Type: Literature]Acetylcholinesterase [gi:113038]
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3
[SID103194169]
EC50 30Stimulation of ion flux in TE671 cells [AID208872, Type: Literature]
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4
[SID103194169]
Agonist efficacy was evaluated as concentration that produces 10-m V depolarization in frog sartorius muscle. [AID71786, Type: Literature]
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5
[SID53812664]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491227]
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6
[SID53812668]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Mutant S203a Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491239]
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7
[SID85209629]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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8
[SID124752895]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). [AID687014, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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9
[SID11111825]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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10
[SID103194169]
Inhibitory potency in anesthetized rhesus monkeys [AID126469, Type: Literature]
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11
[SID103194169]
Duration (90%) measured for NMB activity in anesthetized rhesus monkeys [AID126970, Type: Literature]
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12
[SID103194169]
Onset time was measured for NMB activity in anesthetized rhesus monkeys [AID127134, Type: Literature]
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13
[SID103194169]
Recovery time (25-75 %) measured for NMB activity in anesthetized rhesus monkeys [AID127145, Type: Literature]
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14
[SID103194169]
Inhibition of superior cervical nerve-induced contractions of the nictitating membrane in anesthetized cats; Pre- and post-block increases in twitch tension and short-lived muscle fasciculations 20-30 s after dosing [AID219381, Type: Literature]
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15
[SID103194169]
ED50 Inhibitory potency in anesthetized cats [AID219382, Type: Literature]
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16
[SID103194169]
Inhibition of stimulated vagus nerve-induced bradycardia in anesthetized cats; ND means not data [AID219385, Type: Literature]
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17
[SID103194169]
Duration (90%) measured for NMB activity in anesthetized cats [AID219389, Type: Literature]
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18
[SID103194169]
Onset time was measured for NMB activity in anesthetized cats [AID219390, Type: Literature]
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19
[SID103194169]
Recovery time (25-75 %) measured for NMB activity in anesthetized cats [AID219391, Type: Literature]
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20
[SID103194169]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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21
[SID103194169]
FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of no concern for DILI [AID625278, Type: Literature]
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22
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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23
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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24
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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25
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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26
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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27
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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28
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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29
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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30
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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31
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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32
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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33
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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34
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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35
[SID103194169]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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36
[SID90341285]
Potency 1.5849qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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37
[SID90341285]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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38
[SID90341285]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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39
[SID90341285]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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40
[SID124752895]
TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9 [AID624416, Type: screening]Envelope surface glycoprotein gp160, precursor [Human immunodeficiency virus 1] [gi:9629363]
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41
[SID11111825]
IkB Signaling [AID445, Type: confirmatory]NF-kappa-B inhibitor alpha [Homo sapiens] [gi:10092619]
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42
[SID124752895]
Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_Activity [AID651658, Type: screening]fibroblast growth factor 22 precursor [Homo sapiens] [gi:10190672]
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43
[SID124752895]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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44
[SID11111825]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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45
[SID11111825]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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46
[SID11111825]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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47
[SID11111825]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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48
[SID11111825]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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49
[SID124752895]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
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50
[SID11111825]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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