Succinylcholine (CID 5314) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Inactive(158)
 
 
Inconclusive(7)
 
 
Unspecified(27)
 
 
Top Targets:
p450(10)
 
 
 
Pyruvate Kina..(4)
 
 
7TM GPCR Srx(4)
 
 
 
Pyr redox dim(4)
 
 
PIKKc TOR(4)
 
 
BioAssay Types:
Confirmatory(117)
 
 
 
Literature(34)
 
 
 
 
Screening(31)
 
 
BioActivity Types:
Potency(96)
 
 
 
EC50(1)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 191    Data Row: 199   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194169]
ED50 0.54Dose causing 50% block of muscle twitch in isolated chick biventer cervicis muscle (Decrease in baseline tension) [AID219534, Type: Literature]
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2
[SID103194169]
Ki 21Inhibition of mouse AChE [AID404437, Type: Literature]Acetylcholinesterase [gi:113038]
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3
[SID103194169]
Ki 21Inhibition of mouse AChE [AID404437, Type: Literature]Acetylcholinesterase [gi:113038]
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4
[SID103194169]
EC50 30Stimulation of ion flux in TE671 cells [AID208872, Type: Literature]
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5
[SID103194169]
 Agonist efficacy was evaluated as concentration that produces 10-m V depolarization in frog sartorius muscle. [AID71786, Type: Literature]
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6
[SID53812664]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Mouse Acetylcholinesterase Complexed With Succinylcholine [gi:112491227]
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7
[SID53812668]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Mutant S203a Of Mouse Acetylcholinesterase Complexed With Succinylchol [gi:112491239]
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8
[SID85209629]
 Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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9
[SID103194169]
 Inhibitory potency in anesthetized rhesus monkeys [AID126469, Type: Literature]
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10
[SID103194169]
 Duration (90%) measured for NMB activity in anesthetized rhesus monkeys [AID126970, Type: Literature]
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11
[SID103194169]
 Onset time was measured for NMB activity in anesthetized rhesus monkeys [AID127134, Type: Literature]
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12
[SID103194169]
 Recovery time (25-75 %) measured for NMB activity in anesthetized rhesus monkeys [AID127145, Type: Literature]
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13
[SID103194169]
 Inhibition of superior cervical nerve-induced contractions of the nictitating membrane in anesthetized cats; Pre- and post-block increases in twitch tension and short-lived muscle fasciculations 20-30 s after dosing [AID219381, Type: other]
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14
[SID103194169]
ED50 Inhibitory potency in anesthetized cats [AID219382, Type: Literature]
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15
[SID103194169]
 Inhibition of stimulated vagus nerve-induced bradycardia in anesthetized cats; ND means not data [AID219385, Type: Literature]
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16
[SID103194169]
 Duration (90%) measured for NMB activity in anesthetized cats [AID219389, Type: Literature]
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17
[SID103194169]
 Onset time was measured for NMB activity in anesthetized cats [AID219390, Type: Literature]
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18
[SID103194169]
 Recovery time (25-75 %) measured for NMB activity in anesthetized cats [AID219391, Type: Literature]
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19
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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20
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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21
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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22
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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23
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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24
[SID103194169]
 FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of no concern for DILI [AID625278, Type: Literature]
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25
[SID103194169]
 Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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26
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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27
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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28
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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29
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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30
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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31
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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32
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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33
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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34
[SID103194169]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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35
[SID11111825]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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36
[SID11111825]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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37
[SID90341285]
Potency 1.5849qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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38
[SID90341285]
Potency 1.5849qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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39
[SID90341285]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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40
[SID90341285]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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41
[SID90341285]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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42
[SID90341285]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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43
[SID90341285]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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44
[SID90341285]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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45
[SID90341285]
Potency Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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46
[SID90341285]
Potency Validation screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493107, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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47
[SID11111825]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors [AID901, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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48
[SID11111825]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors [AID901, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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49
[SID124752895]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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50
[SID124752895]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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