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Nalbuphine (CID 5311304) - Compound BioActivity Data
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BioActivity Outcomes:
Active(27)
 
 
Inactive(82)
 
 
Inconclusive(15)
 
 
Unspecified(180)
 
 
Top Targets:
7TM GPCR Srx(49)
 
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
p450(16)
 
 
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD AR(8)
 
 
 
 
BioAssay Types:
Confirmatory(168)
 
 
 
 
 
Literature(80)
 
 
 
 
 
Screening(20)
 
 
Summary(15)
 
 
 
BioActivity Types:
IC50(124)
 
 
 
 
Potency(63)
 
 
 
Ki(8)
 
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 302    Data Row: 304   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103234668]
Ki 0.00089Displacement of [3H]DAMGO from human opioid gamma receptor expressed in CHO cells [AID286302, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID103234668]
IC50 0.001Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligand [AID152239, Type: Literature]
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3
[SID103234668]
Ki 0.0016Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416813, Type: Literature]Mu-type opioid receptor [gi:2851402]
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4
[SID103234668]
Ki 0.0022Displacement of [3H]U-69593 from human opioid kappa receptor expressed in CHO cells [AID286303, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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5
[SID103234668]
Ki 0.003Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416815, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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6
[SID103234668]
EC50 0.014Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding [AID286312, Type: Literature]Mu-type opioid receptor [gi:2851402]
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7
[SID103234668]
IC50 0.024DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: confirmatory]Mu-type opioid receptor [gi:2851402]
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8
[SID103234668]
EC50 0.027Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID286308, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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9
[SID103234668]
EC50 0.046Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417156, Type: Literature]Mu-type opioid receptor [gi:2851402]
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10
[SID103234668]
EC50 0.056Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417160, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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11
[SID103234668]
EC50 0.065Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation counting [AID640424, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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12
[SID103234668]
IC50 0.083Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand [AID147859, Type: Literature]
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13
[SID103234668]
IC50 0.096Antagonist activity against human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding [AID417162, Type: Literature]Mu-type opioid receptor [gi:2851402]
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14
[SID103234668]
IC50 0.11Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as inhibition of DAGO-stimulated [35S]GTPgammaS binding [AID286314, Type: Literature]Mu-type opioid receptor [gi:2851402]
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15
[SID103234668]
IC50 0.111DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: confirmatory]Kappa-type opioid receptor [gi:116242691]
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16
[SID103234668]
Ki 0.24Displacement of [3H]naltrindole from human opioid delta receptor expressed in CHO cells [AID286304, Type: Literature]Delta-type opioid receptor [gi:311033488]
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17
[SID103234668]
EC50 0.25Agonist activity at human KOPR expressed in U2OS cells assessed as beta-arrestin2 recruitment after 90 mins by DiscoveRx PathHunter assay [AID640395, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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18
[SID103234668]
IC50 0.353Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligand [AID148078, Type: Literature]
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19
[SID103234668]
Ki 0.58Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting [AID416814, Type: Literature]Delta-type opioid receptor [gi:311033488]
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20
[SID103234668]
IC50 1.886DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: confirmatory]Delta-type opioid receptor [gi:311033488]
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