Nalbuphine (CID 5311304) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(27)
 
 
Inactive(29)
 
 
Inconclusive(3)
 
 
Unspecified(178)
 
 
Top Targets:
7TM GPCR Srx(40)
 
 
 
 
 
p450(14)
 
 
 
7TM GPCR Srsx(10)
 
 
prostaglandin..(2)
 
 
Tryp SPc(2)
 
 
BioAssay Types:
Literature(77)
 
 
 
 
 
Screening(21)
 
 
Confirmatory(3)
 
 
BioActivity Types:
IC50(123)
 
 
 
 
Ki(8)
 
 
 
EC50(6)
 
 
Potency(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 237    Data Row: 237   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103234668]
Ki 0.00089Displacement of [3H]DAMGO from human opioid gamma receptor expressed in CHO cells [AID286302, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
2
[SID103234668]
Ki 0.00089Displacement of [3H]DAMGO from human opioid gamma receptor expressed in CHO cells [AID286302, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
3
[SID103234668]
Ki 0.00089Displacement of [3H]DAMGO from human opioid gamma receptor expressed in CHO cells [AID286302, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
4
[SID103234668]
Ki 0.00089Displacement of [3H]DAMGO from human opioid gamma receptor expressed in CHO cells [AID286302, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
5
[SID103234668]
IC50 0.001Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligand [AID152239, Type: Literature]
View
6
[SID103234668]
Ki 0.0016Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416813, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
7
[SID103234668]
Ki 0.0016Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416813, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
8
[SID103234668]
Ki 0.0016Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416813, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
9
[SID103234668]
Ki 0.0016Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416813, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
10
[SID103234668]
Ki 0.0022Displacement of [3H]U-69593 from human opioid kappa receptor expressed in CHO cells [AID286303, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
11
[SID103234668]
Ki 0.0022Displacement of [3H]U-69593 from human opioid kappa receptor expressed in CHO cells [AID286303, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
12
[SID103234668]
Ki 0.0022Displacement of [3H]U-69593 from human opioid kappa receptor expressed in CHO cells [AID286303, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
13
[SID103234668]
Ki 0.0022Displacement of [3H]U-69593 from human opioid kappa receptor expressed in CHO cells [AID286303, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
14
[SID103234668]
Ki 0.003Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416815, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
15
[SID103234668]
Ki 0.003Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416815, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
16
[SID103234668]
Ki 0.003Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416815, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
17
[SID103234668]
Ki 0.003Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416815, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
18
[SID103234668]
EC50 0.014Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding [AID286312, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
19
[SID103234668]
EC50 0.014Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding [AID286312, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
20
[SID103234668]
EC50 0.014Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding [AID286312, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
21
[SID103234668]
EC50 0.014Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding [AID286312, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
22
[SID103234668]
IC50 0.024DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
View
23
[SID103234668]
IC50 0.024DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
View
24
[SID103234668]
IC50 0.024DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
View
25
[SID103234668]
IC50 0.024DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
View
26
[SID103234668]
EC50 0.027Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID286308, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
27
[SID103234668]
EC50 0.027Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID286308, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
28
[SID103234668]
EC50 0.027Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID286308, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
29
[SID103234668]
EC50 0.027Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID286308, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
30
[SID103234668]
EC50 0.046Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417156, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
31
[SID103234668]
EC50 0.046Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417156, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
32
[SID103234668]
EC50 0.046Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417156, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
33
[SID103234668]
EC50 0.046Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417156, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
34
[SID103234668]
EC50 0.056Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417160, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
35
[SID103234668]
EC50 0.056Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417160, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
36
[SID103234668]
EC50 0.056Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417160, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
37
[SID103234668]
EC50 0.056Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417160, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
38
[SID103234668]
EC50 0.065Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation counting [AID640424, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
39
[SID103234668]
EC50 0.065Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation counting [AID640424, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
40
[SID103234668]
EC50 0.065Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation counting [AID640424, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
41
[SID103234668]
EC50 0.065Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation counting [AID640424, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
42
[SID103234668]
IC50 0.083Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand [AID147859, Type: Literature]
View
43
[SID103234668]
IC50 0.096Antagonist activity against human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding [AID417162, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
44
[SID103234668]
IC50 0.096Antagonist activity against human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding [AID417162, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
45
[SID103234668]
IC50 0.096Antagonist activity against human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding [AID417162, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
46
[SID103234668]
IC50 0.096Antagonist activity against human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding [AID417162, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
47
[SID103234668]
IC50 0.11Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as inhibition of DAGO-stimulated [35S]GTPgammaS binding [AID286314, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
48
[SID103234668]
IC50 0.11Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as inhibition of DAGO-stimulated [35S]GTPgammaS binding [AID286314, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
49
[SID103234668]
IC50 0.11Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as inhibition of DAGO-stimulated [35S]GTPgammaS binding [AID286314, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
50
[SID103234668]
IC50 0.11Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as inhibition of DAGO-stimulated [35S]GTPgammaS binding [AID286314, Type: Literature]Mu-type opioid receptor [gi:2851402]
View