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BioActivity Data for Compound vorinostat (CID 5311)

BioActivity Outcomes:
Active(2242)
 
 
Inactive(593)
 
 
Inconclusive(82)
 
 
Unspecified(721)
 
 
Top Targets:
HDAC1(133)
 
 
 
 
HDAC6-dom1(98)
 
 
 
 
HDAC2(86)
 
 
 
 
HDAC3(79)
 
 
 
HDAC8(75)
 
 
 
 
BioAssay Types:
Literature(2327)
 
 
 
 
 
Confirmatory(882)
 
 
 
 
 
Screening(365)
 
 
 
 
Summary(42)
 
 
 
 
BioAssay Categories:
In vitro(641)
 
 
 
In vivo(36)
 
 
 
 
Biochemical(1314)
 
 
 
 
 
Toxicity(345)
 
 
 
 
 
ADME(146)
 
 
 
 
Cell-based(1919)
 
 
 
 
 
Organism-base..(13)
 
 
BioActivity Types:
IC50(1764)
 
 
 
 
 
Potency(252)
 
 
 
 
 
EC50(71)
 
 
 
 
 
Ki(44)
 
 
 
 
AC50(30)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3099    Data Row: 3638   Total Pages: 182   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174146]
IC50 0.0006Inhibition of human HepG2 cells [AID316925, Type: Literature]
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2
[SID103174146]
Ki 0.0013Inhibition of human HDAC1 [AID496801, Type: Literature]Histone deacetylase 1 [gi:2498443]
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3
[SID103174146]
Ki 0.0016Inhibition of human HDAC2 [AID496802, Type: Literature]Histone deacetylase 2 [gi:68068066]
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4
[SID103174146]
Ki 0.0016Inhibition of human HDAC6 [AID496806, Type: Literature]Histone deacetylase 6 [gi:205371758]
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5
[SID103174146]
IC50 0.0017Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay [AID669762, Type: Literature]Histone deacetylase 2 [gi:68068066]
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6
[SID103174146]
IC50 0.002Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay [AID732152, Type: Literature]Histone deacetylase 6 [gi:205371758]
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7
[SID103174146]
IC50 0.002Inhibition of HDAC6 (unknown origin) after 60 mins by fluorescence assay [AID748109, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
8
[SID103174146]
IC50 0.0024Inhibition of human HT1080 cells [AID316873, Type: Literature]
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9
[SID103174146]
IC50 0.003Inhibition of HDAC3 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay [AID732145, Type: Literature]Histone deacetylase 3 [gi:3334210]
View
10
[SID103174146]
IC50 0.004Inhibition of HDAC3 (unknown origin) after 60 mins by fluorescence assay [AID748112, Type: Literature]Histone deacetylase 3 [gi:3334210]
View
11
[SID103174146]
IC50 0.004Inhibition of HDAC1 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay [AID732146, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
12
[SID103174146]
Ki 0.005Inhibition of human HDAC3 [AID496803, Type: Literature]Histone deacetylase 3 [gi:3334210]
View
13
[SID103174146]
IC50 0.005Inhibition of HDAC1 (unknown origin) after 60 mins by fluorescence assay [AID748114, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
14
[SID103174146]
IC50 0.005Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assay [AID669763, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
15
[SID103174146]
Ki 0.007Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins [AID765392, Type: Literature]Histone deacetylase 2 [gi:68068066]
View
16
[SID103174146]
Ki 0.008Inhibition of recombinant human HDAC1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins [AID765393, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
17
[SID103174146]
IC50 0.0089Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assay [AID669761, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
18
[SID103174146]
IC50 0.009Inhibition of HDAC6 by in vitro deacetylation assay [AID524999, Type: Literature]
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19
[SID103174146]
IC50 0.0093Inhibition of HDAC6 [AID511066, Type: Literature]
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20
[SID103174146]
IC50 0.0094Inhibition of HDAC6 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assay [AID1141788, Type: Literature]Histone deacetylase 6 [gi:205371758]
View