Bookmark and Share
vorinostat (CID 5311) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(1856)
 
 
Inactive(533)
 
 
Inconclusive(80)
 
 
Unspecified(543)
 
 
Top Targets:
HDAC1(92)
 
 
 
 
HDAC6-dom1(61)
 
 
 
 
HDAC2(54)
 
 
 
 
HDAC3(47)
 
 
 
HDAC8(45)
 
 
 
 
BioAssay Types:
Literature(1795)
 
 
 
 
 
Screening(351)
 
 
 
 
Confirmatory(247)
 
 
 
 
 
Summary(39)
 
 
 
 
BioActivity Types:
IC50(1440)
 
 
 
 
 
Potency(234)
 
 
 
 
 
EC50(66)
 
 
 
 
 
Ki(33)
 
 
 
AC50(6)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2625    Data Row: 3012   Total Pages: 61   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174146]
IC50 0.0006Inhibition of human HepG2 cells [AID316925, Type: Literature]
View
2
[SID103174146]
Ki 0.0013Inhibition of human HDAC1 [AID496801, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
3
[SID103174146]
Ki 0.0016Inhibition of human HDAC2 [AID496802, Type: Literature]Histone deacetylase 2 [gi:68068066]
View
4
[SID103174146]
Ki 0.0016Inhibition of human HDAC6 [AID496806, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
5
[SID103174146]
IC50 0.0017Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay [AID669762, Type: Literature]Histone deacetylase 2 [gi:68068066]
View
6
[SID103174146]
IC50 0.002Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay [AID732152, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
7
[SID103174146]
IC50 0.0024Inhibition of human HT1080 cells [AID316873, Type: Literature]
View
8
[SID103174146]
IC50 0.003Inhibition of HDAC3 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay [AID732145, Type: Literature]Histone deacetylase 3 [gi:3334210]
View
9
[SID103174146]
IC50 0.004Inhibition of HDAC1 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay [AID732146, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
10
[SID103174146]
Ki 0.005Inhibition of human HDAC3 [AID496803, Type: Literature]Histone deacetylase 3 [gi:3334210]
View
11
[SID103174146]
IC50 0.005Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assay [AID669763, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
12
[SID103174146]
IC50 0.0089Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assay [AID669761, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
13
[SID103174146]
IC50 0.009Inhibition of HDAC6 by in vitro deacetylation assay [AID524999, Type: Literature]
View
14
[SID103174146]
IC50 0.0093Inhibition of HDAC6 [AID511066, Type: Literature]
View
15
[SID103174146]
IC50 0.0097Inhibition of human recombinant full-length HDAC1 using fluorophore conjugated substrate by fluorescence assay [AID631666, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
16
[SID103174146]
IC50 0.01Inhibition of HDAC from RT extract [AID420329, Type: Literature]
View
17
[SID103174146]
IC50 0.01Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) prepared from K562 erythroleukemia cells. [AID90347, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
18
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
19
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 3 [gi:3334210]
View
20
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 9 [gi:19865267]
View
21
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
22
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 4 [gi:259016348]
View
23
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 5 [gi:296434519]
View
24
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 2 [gi:68068066]
View
25
[SID103174146]
IC50 0.01Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) prepared from K562 erythroleukemia cells. [AID90347, Type: Literature]Histone deacetylase 2 [gi:68068066]
View
26
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 11 [gi:26394832]
View
27
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 10 [gi:27734403]
View
28
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 8 [gi:29839394]
View
29
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 7 [gi:30913097]
View
30
[SID103174146]
IC50 0.011Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay [AID732154, Type: Literature]Histone deacetylase 2 [gi:68068066]
View
31
[SID103174146]
IC50 0.011Inhibition of HDAC1 [AID488273, Type: Literature]
View
32
[SID103174146]
IC50 0.014Inhibition of HDAC6 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465154, Type: Literature]
View
33
[SID103174146]
IC50 0.014Inhibition of HDAC6 after 17 hrs [AID366644, Type: Literature]
View
34
[SID103174146]
IC50 0.014Inhibition of human recombinant HDAC6 [AID352518, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
35
[SID103174146]
IC50 0.016Inhibition of human recombinant full-length HDAC2 using fluorophore conjugated substrate by fluorescence assay [AID631667, Type: Literature]Histone deacetylase 2 [gi:68068066]
View
36
[SID103174146]
Ki 0.016Inhibition of HDAC4 [AID482944, Type: Literature]
View
37
[SID103174146]
IC50 0.017Inhibition of HDAC3 after 17 hrs [AID366642, Type: Literature]
View
38
[SID103174146]
IC50 0.017Inhibition of HDAC3 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465151, Type: Literature]
View
39
[SID103174146]
IC50 0.017Inhibition of human recombinant HDAC3 [AID352517, Type: Literature]Histone deacetylase 3 [gi:3334210]
View
40
[SID103174146]
IC50 0.018Inhibition of recombinant HDAC6 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis [AID673993, Type: other]
View
41
[SID103174146]
Ki 0.018Inhibition of HDAC6 [AID482946, Type: Literature]
View
42
[SID103174146]
IC50 0.018Inhibition of recombinant human HDAC6 using Fluor-de-Lys as substrate after 30 mins by spectrophotometry [AID652750, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
43
[SID103174146]
IC50 0.018Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry [AID652763, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
44
[SID103174146]
IC50 0.0188Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay [AID331899, Type: Literature]Nuclear receptor corepressor 2 [gi:226713806]
View
45
[SID103174146]
IC50 0.0188Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay [AID331899, Type: Literature]Histone deacetylase 3 [gi:3334210]
View
46
[SID103174146]
IC50 0.019Inhibition of recombinant HDAC6 expressed in HEK293 cells [AID343688, Type: Literature]
View
47
[SID103174146]
IC50 0.0194Inhibition of recombinant HDAC6 (unknown origin) after 10 mins by fluorimetric analysis [AID737915, Type: Literature]Histone deacetylase 6 [gi:205371758]
View
48
[SID103174146]
IC50 0.0198Inhibition of HDAC6 using Boc-Lys(Ac)-AMC as substrate incubated 30 mins before substrate addition measured after 30 mins post substrate addition by fluorescence assay [AID616005, Type: Literature]
View
49
[SID103174146]
Ki 0.02Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assay [AID619049, Type: Literature]
View
50
[SID103174146]
IC50 0.02Inhibition of recombinant HDAC1 in HeLa cells [AID297471, Type: Literature]
View