vorinostat (CID 5311) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1007)
 
 
Inactive(372)
 
 
Inconclusive(29)
 
 
Unspecified(375)
 
 
Top Targets:
HDAC1(81)
 
 
 
 
HDAC6-dom1(34)
 
 
 
HDAC2(22)
 
 
 
 
HDAC8(22)
 
 
 
 
HDAC3(21)
 
 
 
BioAssay Types:
Literature(1375)
 
 
 
 
 
Screening(294)
 
 
 
 
Confirmatory(99)
 
 
 
 
 
BioActivity Types:
IC50(636)
 
 
 
 
 
EC50(66)
 
 
 
 
 
Potency(64)
 
 
 
 
 
Ki(33)
 
 
 
Kd(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1712    Data Row: 1783   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174146]
IC50 0.0006Inhibition of human HepG2 cells [AID316925, Type: Literature]
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2
[SID103174146]
Ki 0.0013Inhibition of human HDAC1 [AID496801, Type: Literature]Histone deacetylase 1 [gi:2498443]
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3
[SID103174146]
Ki 0.0016Inhibition of human HDAC2 [AID496802, Type: Literature]Histone deacetylase 2 [gi:68068066]
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4
[SID103174146]
Ki 0.0016Inhibition of human HDAC6 [AID496806, Type: Literature]Histone deacetylase 6 [gi:205371758]
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5
[SID103174146]
IC50 0.0017Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay [AID669762, Type: Literature]Histone deacetylase 2 [gi:68068066]
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6
[SID103174146]
IC50 0.0024Inhibition of human HT1080 cells [AID316873, Type: Literature]
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7
[SID103174146]
IC50 0.005Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assay [AID669763, Type: Literature]Histone deacetylase 6 [gi:205371758]
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8
[SID103174146]
Ki 0.005Inhibition of human HDAC3 [AID496803, Type: Literature]Histone deacetylase 3 [gi:3334210]
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9
[SID103174146]
Ki 0.005Inhibition of human HDAC3 [AID496803, Type: Literature]Histone deacetylase 3 [gi:3334210]
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10
[SID103174146]
IC50 0.0089Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assay [AID669761, Type: Literature]Histone deacetylase 1 [gi:2498443]
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11
[SID103174146]
IC50 0.009Inhibition of HDAC6 by in vitro deacetylation assay [AID524999, Type: Literature]
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12
[SID103174146]
IC50 0.0093Inhibition of HDAC6 [AID511066, Type: Literature]
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13
[SID103174146]
IC50 0.0097Inhibition of human recombinant full-length HDAC1 using fluorophore conjugated substrate by fluorescence assay [AID631666, Type: Literature]Histone deacetylase 1 [gi:2498443]
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14
[SID103174146]
IC50 0.01Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells [AID90211, Type: Literature]Histone deacetylase 1 [gi:2498443]
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15
[SID103174146]
IC50 0.01Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) prepared from K562 erythroleukemia cells. [AID90347, Type: Literature]Histone deacetylase 1 [gi:2498443]
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16
[SID103174146]
IC50 0.01Inhibition of HDAC from RT extract [AID420329, Type: Literature]
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17
[SID103174146]
IC50 0.011Inhibition of HDAC1 [AID488273, Type: Literature]
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18
[SID103174146]
IC50 0.014Inhibition of HDAC6 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465154, Type: Literature]
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19
[SID103174146]
IC50 0.014Inhibition of HDAC6 after 17 hrs [AID366644, Type: Literature]
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20
[SID103174146]
IC50 0.014Inhibition of human recombinant HDAC6 [AID352518, Type: Literature]Histone deacetylase 6 [gi:205371758]
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21
[SID103174146]
IC50 0.016Inhibition of human recombinant full-length HDAC2 using fluorophore conjugated substrate by fluorescence assay [AID631667, Type: Literature]Histone deacetylase 2 [gi:68068066]
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22
[SID103174146]
Ki 0.016Inhibition of HDAC4 [AID482944, Type: Literature]
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23
[SID103174146]
IC50 0.017Inhibition of HDAC3 after 17 hrs [AID366642, Type: Literature]
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24
[SID103174146]
IC50 0.017Inhibition of HDAC3 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465151, Type: Literature]
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25
[SID103174146]
IC50 0.017Inhibition of human recombinant HDAC3 [AID352517, Type: Literature]Histone deacetylase 3 [gi:3334210]
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26
[SID103174146]
IC50 0.017Inhibition of human recombinant HDAC3 [AID352517, Type: Literature]Histone deacetylase 3 [gi:3334210]
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27
[SID103174146]
IC50 0.018Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry [AID652763, Type: Literature]Histone deacetylase 6 [gi:205371758]
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28
[SID103174146]
IC50 0.018Inhibition of recombinant human HDAC6 using Fluor-de-Lys as substrate after 30 mins by spectrophotometry [AID652750, Type: Literature]Histone deacetylase 6 [gi:205371758]
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29
[SID103174146]
Ki 0.018Inhibition of HDAC6 [AID482946, Type: Literature]
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30
[SID103174146]
IC50 0.018Inhibition of recombinant HDAC6 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis [AID673993, Type: other]
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31
[SID103174146]
IC50 0.0188Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay [AID331899, Type: Literature]Histone deacetylase 3 [gi:3334210]
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32
[SID103174146]
IC50 0.0188Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay [AID331899, Type: Literature]Histone deacetylase 3 [gi:3334210]
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33
[SID103174146]
IC50 0.019Inhibition of recombinant HDAC6 expressed in HEK293 cells [AID343688, Type: Literature]
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34
[SID103174146]
IC50 0.0198Inhibition of HDAC6 using Boc-Lys(Ac)-AMC as substrate incubated 30 mins before substrate addition measured after 30 mins post substrate addition by fluorescence assay [AID616005, Type: Literature]
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35
[SID103174146]
Ki 0.02Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assay [AID619049, Type: Literature]
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36
[SID103174146]
IC50 0.02Inhibition of recombinant HDAC1 in HeLa cells [AID297471, Type: Literature]
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37
[SID103174146]
IC50 0.02Inhibition of human HDAC9 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay [AID593554, Type: Literature]Histone deacetylase 9 [gi:19865267]
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38
[SID103174146]
IC50 0.02Inhibition of human recombinant HDAC1 expressed in HEK293 cells [AID414717, Type: Literature]Histone deacetylase 1 [gi:2498443]
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39
[SID103174146]
IC50 0.021Inhibition of human recombinant HDAC1 expressed in HEK293 cells [AID546547, Type: Literature]Histone deacetylase 1 [gi:2498443]
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40
[SID103174146]
IC50 0.021Inhibition of HDAC1 [AID316892, Type: Literature]
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41
[SID103174146]
Ki 0.021Inhibition of HDAC6 [AID385230, Type: Literature]
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42
[SID103174146]
IC50 0.0216Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay [AID331900, Type: Literature]Histone deacetylase 6 [gi:205371758]
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43
[SID103174146]
IC50 0.0218Inhibition of human recombinant full-length HDAC3 using fluorophore conjugated substrate by fluorescence assay [AID631668, Type: Literature]Histone deacetylase 3 [gi:3334210]
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44
[SID103174146]
IC50 0.0218Inhibition of human recombinant full-length HDAC3 using fluorophore conjugated substrate by fluorescence assay [AID631668, Type: Literature]Histone deacetylase 3 [gi:3334210]
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45
[SID103174146]
IC50 0.022Inhibition of Bordetella / Alcaligenes strain FB188 HDAC6 by fluorescence polarization assay [AID420321, Type: Literature]
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46
[SID103174146]
IC50 0.02237Inhibition of human recombinant HDAC1 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins [AID628437, Type: Literature]Histone deacetylase 1 [gi:2498443]
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47
[SID103174146]
IC50 0.0239Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from HDAC in human HeLa nuclear cell extract by fluorescence polarization assay [AID331898, Type: Literature]
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48
[SID103174146]
IC50 0.024Inhibition of human recombinant HDAC2 using fluor de Lys as substrate by fluorometric analysis [AID605393, Type: Literature]Histone deacetylase 2 [gi:68068066]
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49
[SID103174146]
IC50 0.025Inhibition of human recombinant HDAC6 expressed in HEK293 cells [AID546548, Type: Literature]Histone deacetylase 6 [gi:205371758]
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50
[SID103174146]
IC50 0.025Inhibition of HDAC6 [AID316899, Type: Literature]
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