Bookmark and Share
4-aminopyrrolidine-2,4-dicarboxylic acid (CID 5310984) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(13)
 
 
Inactive(32)
 
 
Inconclusive(2)
 
 
Unspecified(20)
 
 
Top Targets:
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
NR LBD TR(2)
 
 
7tm 3(2)
 
 
 
ANK(2)
 
 
BioAssay Types:
Confirmatory(33)
 
 
 
Literature(30)
 
 
 
 
 
BioActivity Types:
Potency(30)
 
 
 
EC50(13)
 
 
 
Ki(8)
 
 
 
IC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 66    Data Row: 67   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103216567]
EC50 0.2Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor [AID221527, Type: Literature]
View
2
[SID103216567]
EC50 0.3Tested for the agonistic activity against Metabotropic glutamate receptor 2 [AID108983, Type: other]
View
3
[SID103216567]
Ki 0.41Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3). [AID109164, Type: Literature]
View
4
[SID103216567]
Ki 0.45Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2). [AID108830, Type: Literature]
View
5
[SID103216567]
EC50 0.48Effective concentration required for agonistic activity at Metabotropic glutamate receptor 2 [AID108978, Type: Literature]
View
6
[SID103216567]
EC50 1.7Effective concentration required for agonistic activity at Metabotropic glutamate receptor 3 [AID109172, Type: Literature]
View
7
[SID103216567]
EC50 3Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing chimeric mGluR3/1a receptor [AID221665, Type: Literature]
View
8
[SID103216567]
EC50 3.5The effective concentration for 50% glutamate response was measured on Group II Metabotropic glutamate receptor [AID75021, Type: Literature]
View
9
[SID103216567]
IC50 5.7Compound was tested for radioligand using Group II Metabotropic glutamate receptor agonist [AID75025, Type: Literature]
View
10
[SID103216567]
IC50 6.49In vitro ability to displace [3H]glutamate binding to metabotropic glutamate receptors in rat forebrain membranes [AID108348, Type: Literature]
View
11
[SID103216567]
EC50 14.51Inhibition of forskolin-stim cAMP formation in cross-chopped slices of the adult rat cerebral cortex. [AID224978, Type: Literature]
View
12
[SID26752104]
Potency 22.3872qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
View
13
[SID26752104]
Potency 28.1838qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
View
14
[SID103216567]
EC50 100Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive [AID246705, Type: Literature]Metabotropic glutamate receptor 4 [gi:400255]
View
15
[SID103216567]
IC50 100Affinity value against N-methyl-D-aspartate (NMDA) receptor using [3H]-CGS- 19755 in glutamate radioligand binding assay. [AID144463, Type: Literature]
View
16
[SID103216567]
Ki 100Agonist potency against cloned human metabotropic glutamate receptor 1 [AID108489, Type: Literature]
View
17
[SID103216567]
EC50 100Tested for the agonistic activity against Metabotropic glutamate receptor 1 [AID108504, Type: other]
View
18
[SID103216567]
Ki 100Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8). [AID107274, Type: Literature]
View
19
[SID103216567]
IC50 100Affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA in selective radioligand binding assay [AID92205, Type: Literature]
View
20
[SID103216567]
IC50 100Affinity value against Ionotropic glutamate receptor kainate using [3H]-kainic acid in selective radioligand binding assay. [AID93555, Type: Literature]
View
21
[SID103216567]
Ki 100Agonist potency against cloned metabotropic glutamate receptor 5 [AID107059, Type: Literature]
View
22
[SID103216567]
Ki 110Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6). [AID107093, Type: Literature]
View
23
[SID103216567]
EC50 110Tested for the agonistic activity against Metabotropic glutamate receptor 6 [AID107248, Type: other]
View
24
[SID103216567]
EC50 200Tested for the agonistic activity against Metabotropic glutamate receptor 5 [AID107068, Type: other]
View
25
[SID103216567]
Ki 300Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7). [AID107261, Type: Literature]
View
26
[SID103216567]
Ki 300Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4) [AID109341, Type: Literature]
View
27
[SID103216567]
IC50 1000Compound was tested for radioligand using Group II Metabotropic glutamate receptor in the rat brain [AID75026, Type: Literature]
View
28
[SID103216567]
EC50 1000The effective concentration for 50% glutamate response was measured on Group I Metabotropic glutamate receptor [AID75015, Type: Literature]
View
29
[SID103216567]
Augmentation of AMPA-induced excitation after Microelectrophoretic appilcation to intact rat spinal neuron [AID224058, Type: Literature]
View
30
[SID103216567]
Dose dependent blocking of limbic seizures induced by compound 1 by systemically administrating intraperitoneally [AID224976, Type: Literature]
View
31
[SID103216567]
Ratio between EC50 of compound and glutamate measured against Metabotropic glutamate receptor 2 [AID108985, Type: Literature]
View
32
[SID103216567]
Ratio between EC50 of compound and glutamate measured against metabotropic glutamate receptor 1 [AID108506, Type: Literature]
View
33
[SID103216567]
EC50 Stimulation of [3H]IP (tritiated inositol monophosphate) formation in cross-chopped slices of the neonata rat cerebral cortex. [AID224980, Type: Literature]
View
34
[SID26752104]
Potency 79.4328Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
35
[SID26752104]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
36
[SID26752104]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
37
[SID26752104]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
View
38
[SID26752104]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
View
39
[SID26752104]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
40
[SID26752104]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
41
[SID26752104]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
View
42
[SID26752104]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
View
43
[SID26752104]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
44
[SID26752104]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
45
[SID26752104]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
View
46
[SID26752104]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
View
47
[SID26752104]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
View
48
[SID26752104]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
View
49
[SID26752104]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
View
50
[SID26752104]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
View