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4-aminopyrrolidine-2,4-dicarboxylic acid (CID 5310984) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(32)
 
 
Inconclusive(2)
 
 
Unspecified(20)
 
 
Top Targets:
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
ANK(2)
 
 
NR LBD TR(2)
 
 
7tm 3(2)
 
 
 
BioAssay Types:
Confirmatory(37)
 
 
 
 
Literature(30)
 
 
 
 
 
BioActivity Types:
Potency(30)
 
 
 
EC50(13)
 
 
 
Ki(8)
 
 
 
IC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 66    Data Row: 67   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103216567]
EC50 0.2Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor [AID221527, Type: Literature]
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2
[SID103216567]
EC50 0.3Tested for the agonistic activity against Metabotropic glutamate receptor 2 [AID108983, Type: confirmatory]
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3
[SID103216567]
Ki 0.41Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3). [AID109164, Type: Literature]
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4
[SID103216567]
Ki 0.45Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2). [AID108830, Type: Literature]
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5
[SID103216567]
EC50 0.48Effective concentration required for agonistic activity at Metabotropic glutamate receptor 2 [AID108978, Type: Literature]
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6
[SID103216567]
EC50 1.7Effective concentration required for agonistic activity at Metabotropic glutamate receptor 3 [AID109172, Type: Literature]
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7
[SID103216567]
EC50 3Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing chimeric mGluR3/1a receptor [AID221665, Type: Literature]
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8
[SID103216567]
EC50 3.5The effective concentration for 50% glutamate response was measured on Group II Metabotropic glutamate receptor [AID75021, Type: Literature]
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9
[SID103216567]
IC50 5.7Compound was tested for radioligand using Group II Metabotropic glutamate receptor agonist [AID75025, Type: Literature]
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10
[SID103216567]
IC50 6.49In vitro ability to displace [3H]glutamate binding to metabotropic glutamate receptors in rat forebrain membranes [AID108348, Type: Literature]
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11
[SID103216567]
EC50 14.51Inhibition of forskolin-stim cAMP formation in cross-chopped slices of the adult rat cerebral cortex. [AID224978, Type: Literature]
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12
[SID26752104]
Potency 22.3872qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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13
[SID26752104]
Potency 28.1838qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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14
[SID103216567]
EC50 100Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive [AID246705, Type: Literature]Metabotropic glutamate receptor 4 [gi:400255]
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15
[SID103216567]
IC50 100Affinity value against N-methyl-D-aspartate (NMDA) receptor using [3H]-CGS- 19755 in glutamate radioligand binding assay. [AID144463, Type: Literature]
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16
[SID103216567]
Ki 100Agonist potency against cloned human metabotropic glutamate receptor 1 [AID108489, Type: Literature]
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17
[SID103216567]
EC50 100Tested for the agonistic activity against Metabotropic glutamate receptor 1 [AID108504, Type: confirmatory]
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18
[SID103216567]
Ki 100Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8). [AID107274, Type: Literature]
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19
[SID103216567]
IC50 100Affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA in selective radioligand binding assay [AID92205, Type: Literature]
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20
[SID103216567]
IC50 100Affinity value against Ionotropic glutamate receptor kainate using [3H]-kainic acid in selective radioligand binding assay. [AID93555, Type: Literature]
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