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metanicotine (CID 5310967) - Compound BioActivity Data
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BioActivity Outcomes:
Active(14)
 
 
Inactive(32)
 
 
Inconclusive(1)
 
 
Unspecified(2)
 
 
Top Targets:
Neur chan LBD(7)
 
 
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
ANK(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Confirmatory(33)
 
 
 
Literature(16)
 
 
 
BioActivity Types:
Potency(30)
 
 
 
Ki(10)
 
 
EC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 49   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103369533]
Ki 0.025Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2 [AID146638, Type: Literature]
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2
[SID103369533]
Ki 0.026Displacement of [3H]nicotine from human alpha4beta2 nAChR expressed in human SH-EP1 cells [AID705817, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
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3
[SID103369533]
Ki 0.026Displacement of [3H]nicotine from human alpha4beta2 nAChR expressed in human SH-EP1 cells [AID705817, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:1351848]
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4
[SID103369533]
Ki 0.026Displacement of [3H]L-nicotine from alpha-4-beta-2 nAChR in rat cerebral cortex [AID315949, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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5
[SID103369533]
Ki 0.026Displacement of [3H]L-nicotine from alpha-4-beta-2 nAChR in rat cerebral cortex [AID315949, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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6
[SID103369533]
Ki 0.026Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brain [AID146454, Type: Literature]
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7
[SID103369533]
EC50 0.73Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2 [AID146316, Type: Literature]
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8
[SID103369533]
EC50 0.94Compound was evaluated for functional potencies and efficacies at rat nAChR subtype DA release [AID175480, Type: Literature]
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9
[SID103369533]
EC50 4.3Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2 [AID146297, Type: Literature]
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10
[SID103369533]
Ki 5.4Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in human SH-SY5Y cells [AID705815, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:2506129]
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11
[SID103369533]
Ki 5.4Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in human SH-SY5Y cells [AID705815, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
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12
[SID103369533]
Ki 8Displacement of [3H]epibatidine from human alpha7 nAChR expressed in human HEK/RIC3 cells [AID705816, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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13
[SID103369533]
Ki 36Affinity for Nicotinic acetylcholine receptor alpha7 [AID146927, Type: Literature]
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14
[SID103369533]
EC50 46Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic) [AID145356, Type: Literature]
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15
[SID103369533]
EC50 1000Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype TE671 (muscle) [AID145357, Type: Literature]
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16
[SID103369533]
EC50 1000Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic) [AID145657, Type: Literature]
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17
[SID26752048]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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18
[SID26752048]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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19
[SID26752048]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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20
[SID26752048]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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