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metanicotine (CID 5310967) - Compound BioActivity Data
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BioActivity Outcomes:
Active(14)
 
 
Inactive(32)
 
 
Inconclusive(1)
 
 
Unspecified(2)
 
 
Top Targets:
Neur chan LBD(7)
 
 
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
NR LBD TR(2)
 
 
ANK(2)
 
 
BioAssay Types:
Confirmatory(33)
 
 
 
Literature(16)
 
 
 
BioActivity Types:
Potency(30)
 
 
 
Ki(10)
 
 
EC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 49   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103369533]
Ki 0.025Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2 [AID146638, Type: Literature]
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2
[SID103369533]
Ki 0.026Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brain [AID146454, Type: Literature]
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3
[SID103369533]
Ki 0.026Displacement of [3H]L-nicotine from alpha-4-beta-2 nAChR in rat cerebral cortex [AID315949, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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4
[SID103369533]
Ki 0.026Displacement of [3H]L-nicotine from alpha-4-beta-2 nAChR in rat cerebral cortex [AID315949, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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5
[SID103369533]
Ki 0.026Displacement of [3H]nicotine from human alpha4beta2 nAChR expressed in human SH-EP1 cells [AID705817, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
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6
[SID103369533]
Ki 0.026Displacement of [3H]nicotine from human alpha4beta2 nAChR expressed in human SH-EP1 cells [AID705817, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:1351848]
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7
[SID103369533]
EC50 0.73Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2 [AID146316, Type: Literature]
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8
[SID103369533]
EC50 0.94Compound was evaluated for functional potencies and efficacies at rat nAChR subtype DA release [AID175480, Type: Literature]
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9
[SID103369533]
EC50 4.3Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2 [AID146297, Type: Literature]
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10
[SID103369533]
Ki 5.4Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in human SH-SY5Y cells [AID705815, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:2506129]
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11
[SID103369533]
Ki 5.4Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in human SH-SY5Y cells [AID705815, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
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12
[SID103369533]
Ki 8Displacement of [3H]epibatidine from human alpha7 nAChR expressed in human HEK/RIC3 cells [AID705816, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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13
[SID103369533]
Ki 36Affinity for Nicotinic acetylcholine receptor alpha7 [AID146927, Type: Literature]
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14
[SID103369533]
EC50 46Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic) [AID145356, Type: Literature]
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15
[SID103369533]
EC50 1000Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype TE671 (muscle) [AID145357, Type: Literature]
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16
[SID103369533]
EC50 1000Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic) [AID145657, Type: Literature]
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17
[SID26752048]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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18
[SID26752048]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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19
[SID26752048]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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20
[SID26752048]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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21
[SID26752048]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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22
[SID26752048]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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23
[SID26752048]
Potency qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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24
[SID26752048]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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25
[SID26752048]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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26
[SID26752048]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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27
[SID26752048]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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28
[SID26752048]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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29
[SID26752048]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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30
[SID26752048]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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31
[SID26752048]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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32
[SID26752048]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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33
[SID26752048]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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34
[SID26752048]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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35
[SID26752048]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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36
[SID26752048]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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37
[SID26752048]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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38
[SID26752048]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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39
[SID26752048]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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40
[SID26752048]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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41
[SID26752048]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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42
[SID26752048]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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43
[SID26752048]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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44
[SID26752048]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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45
[SID26752048]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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46
[SID26752048]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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47
[SID26752048]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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48
[SID26752048]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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49
[SID26752048]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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