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MLS000111319 (CID 5310801) - Compound BioActivity Data
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BioActivity Outcomes:
Active(46)
 
 
Inactive(768)
 
 
Inconclusive(40)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(571)
 
 
 
 
 
Confirmatory(255)
 
 
 
 
 
Literature(18)
 
 
 
 
 
BioActivity Types:
Potency(169)
 
 
 
 
 
IC50(59)
 
 
 
 
EC50(15)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 785    Data Row: 857   Total Pages: 43   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7975880]
IC50 0.0926Luminescence-based cell-based high throughput dose response assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID687017, Type: confirmatory]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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2
[SID7975880]
Potency 0.12qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID7975880]
Potency 0.1458qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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4
[SID103566183]
IC50 0.3Inhibition of Photinus pyralis luciferase [AID328182, Type: Literature]
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5
[SID7975880]
Potency 0.3162qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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6
[SID7975880]
Potency 0.3981qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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7
[SID103566183]
IC50 0.9Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assay [AID328185, Type: Literature]
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8
[SID103566183]
IC50 1.2Inhibition of Photinus pyralis luciferase by Easy lite assay [AID328183, Type: Literature]
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9
[SID103566183]
IC50 1.2Inhibition of Photinus pyralis luciferase by PK-Light assay [AID328181, Type: Literature]
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10
[SID103566183]
IC50 1.9Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay [AID328186, Type: Literature]
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11
[SID7975880]
Potency 3.9811qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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12
[SID7975880]
EC50 7.203Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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13
[SID7975880]
EC50 7.421Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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14
[SID7975880]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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15
[SID7975880]
Potency 10VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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16
[SID7975880]
Potency 10qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor, partial [Homo sapiens] [gi:1724069]
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17
[SID7975880]
Potency 12.5893qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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18
[SID7975880]
Potency 25.1189qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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19
[SID7975880]
Counterscreen for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID599, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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20
[SID7975880]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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