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BRN 1252082 (CID 5310669) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(786)
 
 
Inconclusive(22)
 
 
Unspecified(9)
 
 
Top Targets:
7tm 4(48)
 
 
NR LBD PPAR(15)
 
 
 
 
alkPPc(14)
 
 
Tryp SPc(13)
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(573)
 
 
 
 
Confirmatory(235)
 
 
 
 
 
Literature(24)
 
 
 
 
BioActivity Types:
Potency(165)
 
 
 
 
 
IC50(50)
 
 
 
EC50(17)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 778    Data Row: 851   Total Pages: 43   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7973370]
Potency 0.9178qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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2
[SID7973370]
Potency 2.5119qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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3
[SID7973370]
Potency 2.5119qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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4
[SID7973370]
Potency 3.1623qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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5
[SID7973370]
Potency 3.5481qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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6
[SID7973370]
Potency 11.2202qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression [AID624202, Type: confirmatory]BRCA1 [Homo sapiens] [gi:1698399]
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7
[SID7973370]
Potency 13.4591qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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8
[SID103699275]
EC50 15.38Agonist activity at human PPARgamma expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736343, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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9
[SID103699275]
EC50 15.38Agonist activity at human PPARgamma assessed as luciferase activity by transactivation assay [AID439369, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
10
[SID103699275]
EC50 23.1Agonist activity at human PPARalpha expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736344, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
11
[SID103699275]
EC50 24.39Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736342, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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12
[SID7973370]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
View
13
[SID7973370]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
View
14
[SID103699275]
EC50 33.13Agonist activity at human PPARalpha assessed as luciferase activity by transactivation assay [AID439370, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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15
[SID7973370]
Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID560, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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16
[SID7973370]
Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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17
[SID7973370]
Counterscreen for activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM): Luminescence-based cell-based high throughput screening assay to identify non-selective compounds using the VP16 reporter assay [AID686939, Type: screening]
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18
[SID7973370]
Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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19
[SID7973370]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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20
[SID7973370]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Retesting of KCC2 cells with Ouabain [AID1717, Type: other]
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