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AC1NSIQR (CID 5310346) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(33)
 
 
Inactive(864)
 
 
Inconclusive(31)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
7TM GPCR Srsx(21)
 
 
TRP 2(20)
 
 
 
NACHT(16)
 
 
 
 
alkPPc(14)
 
 
BioAssay Types:
Screening(617)
 
 
 
 
 
Confirmatory(283)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(169)
 
 
 
 
 
IC50(76)
 
 
 
EC50(14)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 866    Data Row: 936   Total Pages: 19   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID87225488]
Summary assay for the identification of compounds that inhibit NOD1 [AID1575, Type: summary]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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2
[SID7970927]
Potency 0.9285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID87225488]
IC50_Mean 0.986SAR analysis of compounds that inhibit NOD1 - Set 2 [AID2466, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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4
[SID89650212]
IC50_Mean 1.36SAR analysis of compounds that inhibit NOD1 - Set 3 [AID2798, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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5
[SID89650203]
IC50_Mean 1.8SAR analysis of compounds that inhibit NOD1 - Set 3 [AID2798, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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6
[SID87225488]
IC50_Mean 1.81SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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7
[SID87225488]
IC50 3.43SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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8
[SID87225488]
IC50_Mean 4.18SAR analysis of compounds that inhibit NOD2 - Set 2 [AID2475, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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9
[SID7970927]
EC50 6.37uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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10
[SID89650212]
IC50_Mean 7.97SAR analysis of compounds that inhibit NOD2 - Set 3 [AID2799, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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11
[SID87225488]
IC50_Mean 8.49SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 2 [AID2483, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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12
[SID89650203]
IC50_Mean 10.6SAR analysis of compounds that inhibit NOD2 - Set 3 [AID2799, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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13
[SID87225488]
IC50 14.43SAR analysis of NF-kappaB dependent luciferase using DAP as an inducer - Set 2 [AID2793, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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14
[SID87225488]
IC50_Mean 16.9SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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15
[SID89650212]
IC50_Mean 18.2SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3 [AID2801, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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16
[SID7970927]
Potency 44.6684qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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17
[SID7970927]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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18
[SID7970927]
CHOP Confirmatory Screen [AID504437, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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19
[SID7970927]
Parallel artificial membrane permeability assay at pH 7.4 [AID624339, Type: other]
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20
[SID7970927]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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21
[SID7970927]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Counterscreen with HEK cells [AID1716, Type: other]
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22
[SID7970927]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Counterscreen 2 with HEK cells [AID1718, Type: other]
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23
[SID7970927]
Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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24
[SID7970927]
Allosteric Modulators of D1 Receptors: Confirmation Screen [AID642, Type: other]
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25
[SID7970927]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen [AID1456, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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26
[SID7970927]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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27
[SID7970927]
Second confirmatory screen for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2554, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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28
[SID7970927]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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29
[SID7970927]
CYP2C19 Assay [AID778, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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30
[SID7970927]
High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar Compartment [AID2417, Type: screening]polypyrimidine tract-binding protein 1 isoform a [Homo sapiens] [gi:4506243]
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31
[SID7970927]
Allosteric Modulators of D1 Receptors: Dose-dependent Assay [AID858, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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32
[SID7970927]
Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2227, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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33
[SID7970927]
Second counter screen for compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID434979, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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34
[SID7970927]
Confirmatory screen for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2555, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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35
[SID7970927]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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36
[SID7970927]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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37
[SID7970927]
Plasma Stability Mouse - Set 2 [AID624419, Type: other]
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38
[SID7970927]
Plasma Stability Human - 2 [AID624420, Type: other]
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39
[SID7970927]
Mouse hepatic microsome stability - Set 2 [AID624451, Type: screening]
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40
[SID7970927]
Human hepatic microsome stability-Set 2 [AID624452, Type: screening]
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41
[SID7970927]
Early assessment of compound stability in 1x PBS - Set 2 [AID624456, Type: other]
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42
[SID7970927]
Potency 3.5481qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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43
[SID7970927]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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44
[SID7970927]
Absolute IC50 (XBP1) 10XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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45
[SID7970927]
Absolute IC50 (CHOP) 10CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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46
[SID7970927]
IC50 16.223uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells [AID2001, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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47
[SID89650203]
IC50_Mean 18.6SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3 [AID2801, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
View
48
[SID7970927]
Potency 19.9526qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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49
[SID7970927]
IC50 20HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction [AID2485, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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50
[SID87225488]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 - Set 2 [AID2469, Type: confirmatory]
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