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BioActivity Data for Compound 1-(4-cyanophenyl)-3-(6-methylpyridin-2-yl)urea (CID 5309919)

BioActivity Outcomes:
Active(45)
 
 
Inactive(793)
 
 
Inconclusive(29)
 
 
Unspecified(5)
 
 
Top Targets:
7tm 4(48)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
 
ABCC CFTR1(9)
 
 
 
 
BioAssay Types:
Screening(576)
 
 
 
 
Confirmatory(269)
 
 
 
 
 
Literature(11)
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(1)
 
 
Biochemical(124)
 
 
Toxicity(10)
 
 
Cell-based(151)
 
 
 
Organism-base..(13)
 
 
BioActivity Types:
Potency(175)
 
 
 
 
 
IC50(56)
 
 
 
 
EC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 792    Data Row: 872   Total Pages: 44   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7969351]
Potency 2.5119qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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2
[SID7969351]
Potency 4.1095qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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3
[SID7969351]
Potency 6.5131qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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4
[SID7969351]
Potency 8.1995qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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5
[SID7969351]
Potency 11.2202qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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6
[SID7969351]
Potency 14.581A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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7
[SID7969351]
Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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8
[SID7969351]
Counterscreen assay for STAT1 activators: Cell-based high throughput assay to measure NF-kappaB activation [AID1306, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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9
[SID7969351]
Confirmation cell-based high throughput screening assay to measure STAT1 activation [AID1262, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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10
[SID7969351]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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11
[SID7969351]
Counterscreen assay for STAT1 activators: Cell-based high throughput assay to measure STAT3 activation [AID1316, Type: screening]STAT3, partial [Homo sapiens] [gi:13272532]
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12
[SID7969351]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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13
[SID7969351]
Counterscreen for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA): A cell-based dose-response assay for inhibition of the Steroidogenic Factor 1 (SF-1) [AID611, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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14
[SID7969351]
Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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15
[SID7969351]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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16
[SID7969351]
Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) antagonists [AID612, Type: screening]5-hydroxytryptamine receptor 1A [Homo sapiens] [gi:55956923]
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17
[SID7969351]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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18
[SID7969351]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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19
[SID7969351]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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20
[SID7969351]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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