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SMR000093473 (CID 5309717) - Compound BioActivity Data
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BioActivity Outcomes:
Active(47)
 
 
Inactive(806)
 
 
Inconclusive(29)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
 
BioAssay Types:
Screening(597)
 
 
 
 
Confirmatory(264)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(170)
 
 
 
 
 
IC50(51)
 
 
 
EC50(11)
 
 
 
AC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 817    Data Row: 883   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24838550]
AC50_uM 1.35Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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2
[SID24838550]
IC50_Mean 2.22Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602464, Type: confirmatory]Gli1 [Mus musculus] [gi:6009644]
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3
[SID7969004]
Potency 2.5119qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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4
[SID7969004]
Potency 2.9362Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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5
[SID24838550]
AC50_uM 3.74Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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6
[SID7969004]
Potency 5.0119qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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7
[SID24838550]
Potency 5.1735qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID24838550]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID24838550]
IC50 7.91Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2) [AID720548, Type: confirmatory]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
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10
[SID24838550]
IC50_Mean 8.48Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651570, Type: confirmatory]protein Wnt-3a precursor [Mus musculus] [gi:7106447]
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11
[SID24838550]
Potency 12.9953Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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12
[SID7969004]
Potency 25.1189qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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13
[SID7969004]
Potency 31.6228qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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14
[SID7969004]
EC50 58.838High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Dose Response [AID1045, Type: confirmatory]
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15
[SID24838550]
AC50_uM 62.05Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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16
[SID7969004]
EC50 79.456High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Dose Response [AID1047, Type: confirmatory]
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17
[SID7969004]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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18
[SID24838550]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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19
[SID7969004]
Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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20
[SID24838550]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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21
[SID24838550]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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22
[SID7969004]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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23
[SID7969004]
Counterscreen for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA): A cell-based dose-response assay for inhibition of the Steroidogenic Factor 1 (SF-1) [AID611, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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24
[SID24838550]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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25
[SID7969004]
Cell Proliferation & Viability (Cytotoxicity) Primary Assay 60K MLSMR [AID463, Type: screening]
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26
[SID24838550]
Single concentration confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via a fluorescent based assay [AID624504, Type: screening]
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27
[SID7969004]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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28
[SID24838550]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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29
[SID24838550]
Luminescence-based cell-based high throughput confirmation assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624378, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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30
[SID24838550]
Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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31
[SID7969004]
Counterscreen assay for STAT3 inhibitors: Cell-based high throughput assay to measure NF-kappaB inhibition. [AID1308, Type: screening]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
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32
[SID7969004]
Primary HTS Assay for S1P3 Antagonists [AID485, Type: screening]sphingosine 1-phosphate receptor 3 [Homo sapiens] [gi:38788193]
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33
[SID24838550]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). [AID588824, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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34
[SID7969004]
Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Agonist Assay 60K MLSMR [AID468, Type: confirmatory]sphingosine 1-phosphate receptor 1 [Homo sapiens] [gi:13027636]
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35
[SID7969004]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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36
[SID7969004]
Primary HTS and Confirmation Assays for S1P1 Agonists and Agonism Potentiators [AID449, Type: screening]sphingosine 1-phosphate receptor 1 [Homo sapiens] [gi:13027636]
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37
[SID7969004]
Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Potentiator Assay 60K MLSMR [AID466, Type: confirmatory]sphingosine 1-phosphate receptor 1 [Homo sapiens] [gi:13027636]
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38
[SID7969004]
Primary cell-based high throughput screening assay to measure STAT3 inhibition [AID862, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
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39
[SID7969004]
Confirmation cell-based high throughput screening assay to measure STAT3 inhibition [AID1265, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
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40
[SID7969004]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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41
[SID24838550]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
View
42
[SID24838550]
Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of COUP-TFII (NR2F2) [AID687008, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
View
43
[SID7969004]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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44
[SID7969004]
Counterscreen assay for STAT3 inhibitors: Cell-based high throughput assay to measure STAT1 inhibition [AID1317, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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45
[SID7969004]
Primary Cell-based High Throughput Screening assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID561, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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46
[SID7969004]
Counterscreen for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID599, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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47
[SID7969004]
Dose-response cell-based assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID610, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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48
[SID24838550]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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49
[SID7969004]
Potency 2.5119qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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50
[SID24838550]
Potency 5.0119qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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