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MLS000116958 (CID 5308351) - Compound BioActivity Data
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BioActivity Outcomes:
Active(35)
 
 
Inactive(473)
 
 
Inconclusive(14)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
Bcl-2 like(12)
 
 
7TM GPCR Srsx(10)
 
 
alkPPc(10)
 
 
Tryp SPc(8)
 
 
BioAssay Types:
Screening(331)
 
 
 
 
Confirmatory(176)
 
 
 
 
Literature(2)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(102)
 
 
 
 
IC50(40)
 
 
 
EC50(13)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 489    Data Row: 522   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7966646]
Potency 0.2818qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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2
[SID7966646]
Potency 0.5623qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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3
[SID7966646]
Potency 1.5101qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID7966646]
EC50 1.738Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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5
[SID7966646]
Potency 2.0596qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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6
[SID7966646]
Potency 3.6626qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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7
[SID7966646]
Potency 3.9811qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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8
[SID7966646]
Potency 4.4668Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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9
[SID7966646]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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10
[SID7966646]
IC50 5.983Dose response cell-based assay to measure STAT3 inhibition [AID1399, Type: confirmatory]STAT3 [Homo sapiens] [gi:13272532]
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11
[SID7966646]
Potency 6.3096qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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12
[SID7966646]
Potency 6.5064Secondary Assay for Luciferase (Kinase-Glo TM) Inhibition Counterscreen [AID2530, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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13
[SID7966646]
EC50 6.564Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase [AID1891, Type: confirmatory]
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14
[SID7966646]
Potency 7.0795qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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15
[SID7966646]
Potency 7.0795qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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16
[SID7966646]
EC50 8.296Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast [AID1936, Type: confirmatory]
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17
[SID7966646]
EC50 8.32Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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18
[SID7966646]
Potency 11.2202qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]pyruvate kinase PKM isoform a [Homo sapiens] [gi:33286418]
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19
[SID7966646]
Potency 18.3375Confirmation Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID2559, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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20
[SID7966646]
qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK): Summary [AID2266, Type: summary]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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21
[SID7966646]
Confirmation cell-based high throughput screening assay to measure STAT3 inhibition [AID1265, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
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22
[SID7966646]
Primary cell-based high throughput screening assay to measure STAT3 inhibition [AID862, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
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23
[SID7966646]
Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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24
[SID7966646]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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25
[SID7966646]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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26
[SID7966646]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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27
[SID7966646]
Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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28
[SID7966646]
Identification of compounds which are cytotoxic to PPC-1 cells. [AID1447, Type: screening]
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29
[SID7966646]
MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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30
[SID7966646]
MLPCN Platelet Activation -Dense Granule Release [AID1663, Type: screening]
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31
[SID7966646]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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32
[SID7966646]
CYP2C19 Assay [AID778, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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33
[SID7966646]
uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells [AID1443, Type: screening]tumor necrosis factor ligand superfamily member 10 isoform 1 [Homo sapiens] [gi:4507593]
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34
[SID7966646]
Counterscreen for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID599, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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35
[SID7966646]
Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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36
[SID7966646]
Potency 0.3696Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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37
[SID7966646]
Potency 1.5849qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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38
[SID7966646]
Potency 7.0795qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1722, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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39
[SID7966646]
Potency 11.2202qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase [AID1631, Type: confirmatory]pyruvate kinase PKM isoform a [Homo sapiens] [gi:33286418]
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40
[SID7966646]
IC50 12.91Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition [AID1411, Type: confirmatory]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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41
[SID7966646]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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42
[SID7966646]
Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1051, Type: other]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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43
[SID7966646]
Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1) [AID1424, Type: screening]transient receptor potential cation channel, subfamily N, member 1 [Danio rerio] [gi:34330186]
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44
[SID7966646]
IC50 Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP) [AID1445, Type: confirmatory]m1-family aminopeptidase [Plasmodium falciparum 3D7] [gi:124512980]
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45
[SID7966646]
Potency qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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46
[SID7966646]
Potentiators of Human D1 Dopamine Receptor: qHTS [AID504651, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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47
[SID7966646]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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48
[SID7966646]
Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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49
[SID7966646]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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50
[SID7966646]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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