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SMR000094249 (CID 5308230) - Compound BioActivity Data
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BioActivity Outcomes:
Active(48)
 
 
Inactive(795)
 
 
Inconclusive(30)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(14)
 
 
Tryp SPc(12)
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(583)
 
 
 
 
 
Confirmatory(271)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(167)
 
 
 
 
 
IC50(51)
 
 
 
 
EC50(22)
 
 
 
AC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 810    Data Row: 875   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99517154]
EC50 0.28153Late stage results for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based cell-based dose response assay for AHR activators [AID493060, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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2
[SID7966434]
EC50 0.48293Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID463088, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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3
[SID7966434]
IC50 3.777Dose response cell-based assay to measure STAT3 activation [AID1398, Type: confirmatory]STAT3 [Homo sapiens] [gi:13272532]
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4
[SID7966434]
EC50_MICROM 4.247MLSCN Assay for Activators of Prostate Cell Differentiation: Counter Screen Dose Response of Potential Cell Killers [AID1200, Type: confirmatory]
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5
[SID7966434]
AC50_uM 6.072Ste24 Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-03_Inhibitor_Dose_CherryPick_Activity [AID488815, Type: confirmatory]STE24 [Saccharomyces cerevisiae] [gi:1015837]
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6
[SID7966434]
Potency 6.3096qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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7
[SID7966434]
EC50_MICROM 6.414MLSCN Assay for Activators of Prostate Cell Differentiation: Primary Dose Response Assay [AID1198, Type: confirmatory]
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8
[SID7966434]
AC50_uM 7.051Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick [AID488788, Type: confirmatory]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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9
[SID162403632]
AC50_uM 7.4Effect of RAD 52 Inhibitors on Growth of CAPAN-1 Cells Measured in Cell-Based System Using Imaging - 7018-03_Inhibitor_Dose_DryPowder_Activity_Set2 [AID743275, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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10
[SID7966434]
Potency 10qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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11
[SID162403632]
AC50_uM 10.45Effect of RAD 52 Inhibitors on Growth of CAPAN-1 Cells Measured in Cell-Based System Using Imaging - 7018-03_Inhibitor_Dose_DryPowder_Activity_Set3 [AID743276, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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12
[SID7966434]
AC50_uM 15.78Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity [AID588849, Type: confirmatory]CAAX prenyl protease 2 isoform 2 [Homo sapiens] [gi:73858575]
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13
[SID7966434]
Potency 25.1189qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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14
[SID7966434]
Potency 25.1189qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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15
[SID7966434]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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16
[SID7966434]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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17
[SID87342166]
AC50_uM 33.62Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity [AID651657, Type: confirmatory]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
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18
[SID7966434]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting Enzyme [AID2563, Type: screening]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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19
[SID87342166]
Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity [AID602329, Type: screening]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
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20
[SID7966434]
High-content cell-based screening for modulators of autophagy [AID463193, Type: screening]microtubule-associated proteins 1A/1B light chain 3A isoform b [Homo sapiens] [gi:31563518]
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21
[SID87342166]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) [AID652067, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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22
[SID7966434]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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23
[SID7966434]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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24
[SID7966434]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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25
[SID7966434]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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26
[SID7966434]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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27
[SID7966434]
Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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28
[SID7966434]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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29
[SID7966434]
Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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30
[SID7966434]
MLSCN Assay for Activators of Prostate Cell Differentiation [AID795, Type: screening]
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31
[SID7966434]
High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression [AID818, Type: screening]
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32
[SID7966434]
High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Pilot Screen [AID823, Type: screening]
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33
[SID7966434]
High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Pilot Screen [AID824, Type: screening]
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34
[SID7966434]
High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor [AID827, Type: screening]
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35
[SID7966434]
Leishmania major promastigote HTS [AID1063, Type: screening]
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36
[SID7966434]
MLSCN Assay for Activators of Prostate Cell Differentiation: Single point confirmation of side scatter shift [AID1069, Type: screening]
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37
[SID87342166]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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38
[SID7966434]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
39
[SID7966434]
Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
40
[SID7966434]
uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]ubiquitin-conjugating enzyme E2 N [Homo sapiens] [gi:4507793]
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41
[SID99517154]
Late stage assay provider counterscreen for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based Human Hepatoma (HG2L7.5c1) Cell-based assay to identify activators of AhR [AID602171, Type: other]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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42
[SID7966434]
Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2227, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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43
[SID87342166]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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44
[SID87342166]
Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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45
[SID7966434]
Confirmation cell-based high throughput screening assay to measure STAT3 activation [AID1267, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
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46
[SID7966434]
Primary cell-based high throughput screening assay to measure STAT3 activation [AID871, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
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47
[SID7966434]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1531, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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48
[SID7966434]
Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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49
[SID87342166]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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50
[SID7966434]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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