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GNF-Pf-4328 (CID 5307801) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(817)
 
 
Inconclusive(13)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(12)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(555)
 
 
 
 
Confirmatory(254)
 
 
 
 
 
Literature(17)
 
 
 
 
BioActivity Types:
Potency(170)
 
 
 
 
 
IC50(47)
 
 
EC50(19)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 775    Data Row: 845   Total Pages: 43   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7965738]
EC50 0.11666Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID463088, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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2
[SID99517153]
EC50 0.21674Late stage results for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based cell-based dose response assay for AHR activators [AID493060, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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3
[SID103710647]
EC50 0.595NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: Literature]
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4
[SID103710647]
EC50 0.728NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: Literature]
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5
[SID7965738]
Potency 2.3323Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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6
[SID7965738]
Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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7
[SID7965738]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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8
[SID99517153]
Late stage assay provider counterscreen for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based Human Hepatoma (HG2L7.5c1) Cell-based assay to identify activators of AhR [AID602171, Type: other]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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9
[SID7965738]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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10
[SID7965738]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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11
[SID7965738]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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12
[SID103710647]
CC50 100NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: Literature]
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13
[SID103710647]
NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. [AID449706, Type: Literature]
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14
[SID7965738]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID103710647]
NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. [AID602118, Type: Literature]
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16
[SID7965738]
Potency 0.1259qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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17
[SID7965738]
Potency 3.5481qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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18
[SID7965738]
Potency 35.4813qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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19
[SID7965738]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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20
[SID99517153]
EC50 116.135Late stage counterscreen results for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based cell-based dose response assay for activators of the Pregnane X Receptor (PXR) [AID493061, Type: confirmatory]nuclear receptor subfamily 1 group I member 2 isoform 1 [Homo sapiens] [gi:34398348]
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