CHEMBL1766982 (CID 52937413) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Unspecified(3)
 
 
Top Targets:
NOS oxygenase..(3)
 
 
 
prostaglandin..(1)
 
 
BioAssay Types:
Literature(6)
 
 
 
BioActivity Types:
IC50(5)
 
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID131286217]
IC50 7.12Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISA [AID591430, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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2
[SID131286217]
IC50 13.92Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method [AID591429, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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3
[SID131286217]
IC50 34.08Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysis [AID591428, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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4
[SID131286217]
IC50 100Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay [AID591431, Type: Literature]
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5
[SID131286217]
IC50 100Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay [AID591432, Type: Literature]
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6
[SID131286217]
 Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method relative to control [AID591398, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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