CHEMBL1765957 (CID 52937356) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(1)
 
 
Unspecified(5)
 
 
Top Targets:
NR LBD Lrh-1(7)
 
 
 
 
NR LBD SF-1(7)
 
 
 
BioAssay Types:
Literature(15)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 15   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID131280925]
 Agonist activity at human LRH-1 ligand binding domain at 100 uM with Coomassie blue staining by PAGE method [AID593534, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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2
[SID131280925]
 Agonist activity at human LRH-1 ligand binding domain at 100 uM with Coomassie blue staining by PAGE method [AID593534, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
View
3
[SID131280925]
 Agonist activity human LRH-1 in HEK293 cells assessed as increase in SHP mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593614, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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4
[SID131280925]
 Agonist activity human LRH-1 in HEK293 cells assessed as increase in SHP mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593614, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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5
[SID131280925]
 Agonist activity human LRH-1 in HEK293 cells assessed as increase in StAR mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593615, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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6
[SID131280925]
 Agonist activity human LRH-1 in HEK293 cells assessed as increase in StAR mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593615, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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7
[SID131280925]
 Agonist activity human LRH-1 in HEK293 cells assessed as increase in GOS2 mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593617, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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8
[SID131280925]
 Agonist activity human LRH-1 in HEK293 cells assessed as increase in GOS2 mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593617, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
View
9
[SID131280925]
 Agonist activity at mouse SF-1 expressed in HEK293 cells assessed as increase in SHP mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593537, Type: Literature]Steroidogenic factor 1 [gi:341942103]
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10
[SID131280925]
 Agonist activity at mouse SF-1 expressed in HEK293 cells assessed as increase in StAR mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593538, Type: Literature]Steroidogenic factor 1 [gi:341942103]
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11
[SID131280925]
 Agonist activity at mouse SF-1 expressed in HEK293 cells assessed as increase in GOS2 mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593539, Type: Literature]Steroidogenic factor 1 [gi:341942103]
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12
[SID131280925]
 Agonist activity at mouse SF-1 expressed in HEK293 cells assessed as increase in MeOx1 mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593613, Type: Literature]Steroidogenic factor 1 [gi:341942103]
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13
[SID131280925]
 Displacement of dipalmitoyl phosphatidylinositol 4,5-bisphosphate from mouse SF-1 ligand binding domain at 1 uM after 16 hrs with Coomassie blue staining by PAGE method [AID593522, Type: Literature]Steroidogenic factor 1 [gi:341942103]
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14
[SID131280925]
 Solubility of the compound [AID593530, Type: Literature]
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15
[SID131280925]
 Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay [AID593526, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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16
[SID131280925]
 Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay [AID593526, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
View
17
[SID131280925]
 Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control [AID593528, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
View
18
[SID131280925]
 Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control [AID593528, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
View
19
[SID131280925]
 Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control [AID593529, Type: Literature]Steroidogenic factor 1 [gi:3121738]
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20
[SID131280925]
 Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control [AID593529, Type: Literature]Steroidogenic factor 1 [gi:3121738]
View
21
[SID131280925]
 Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control [AID593529, Type: Literature]Steroidogenic factor 1 [gi:3121738]
View
22
[SID131280925]
 Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay [AID593527, Type: Literature]Steroidogenic factor 1 [gi:3121738]
View
23
[SID131280925]
 Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay [AID593527, Type: Literature]Steroidogenic factor 1 [gi:3121738]
View
24
[SID131280925]
 Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay [AID593527, Type: Literature]Steroidogenic factor 1 [gi:3121738]
View
25
[SID131280925]
 Agonist activity human LRH-1 in HEK293 cells assessed as increase in MeOx1 mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593616, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
View
26
[SID131280925]
 Agonist activity human LRH-1 in HEK293 cells assessed as increase in MeOx1 mRNA levels at 10 uM after 24 hrs by RT-qPCR method [AID593616, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
View