imatinib (CID 5291) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(345)
 
 
Inactive(381)
 
 
Inconclusive(49)
 
 
Unspecified(1519)
 
 
Top Targets:
PKc(108)
 
 
 
PKc like(79)
 
 
 
 
STKc AGC(70)
 
 
 
 
PTKc Abl(59)
 
 
 
 
PTKc Kit(31)
 
 
 
 
BioAssay Types:
Literature(1999)
 
 
 
 
 
Confirmatory(133)
 
 
 
 
 
Screening(10)
 
 
 
BioActivity Types:
Kd(882)
 
 
 
 
IC50(309)
 
 
 
 
Potency(93)
 
 
 
 
 
Ki(10)
 
 
EC50(5)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2007    Data Row: 2294   Total Pages: 46   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103245522]
Ki 3.08e-08Inhibition of PTK [AID442505, Type: Literature]
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2
[SID103245522]
IC50 0.0002Cytotoxicity against human EOL-1 cells after 72 hrs by alamar-blue cell viability assay [AID414750, Type: Literature]
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3
[SID103245522]
Kd 0.0007Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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4
[SID103245522]
Kd 0.0007Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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5
[SID103245522]
Kd 0.0007Binding constant for DDR1 kinase domain [AID435400, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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6
[SID103245522]
Kd 0.0007Binding constant for DDR1 kinase domain [AID435400, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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7
[SID103245522]
Kd 0.0011Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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8
[SID103245522]
Kd 0.0011Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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9
[SID103245522]
IC50 0.0011Inhibition of wild type Bcr-Abl [AID463630, Type: Literature]
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10
[SID103245522]
Kd 0.0018Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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11
[SID103245522]
Kd 0.0018Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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12
[SID103245522]
Kd 0.0022Average Binding Constant for ABL1 ; NA=Not Active at 10 uM [AID256665, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103245522]
Kd 0.0022Average Binding Constant for ABL1 ; NA=Not Active at 10 uM [AID256665, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID103245522]
Kd 0.0025Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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15
[SID103245522]
Kd 0.0025Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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16
[SID103245522]
Kd 0.0059Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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17
[SID103245522]
Kd 0.0059Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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18
[SID103245522]
Kd 0.006Binding affinity to human active site of N-terminal hexahistidine-tagged ABL2 expressed in Trichoplusia ni infected Sf9 cells by isothermal titration calorimetric assay [AID593557, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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19
[SID103245522]
Kd 0.006Binding affinity to human active site of N-terminal hexahistidine-tagged ABL2 expressed in Trichoplusia ni infected Sf9 cells by isothermal titration calorimetric assay [AID593557, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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20
[SID103245522]
IC50 0.00605Antiproliferative activity against human imatinib-resistant K562 cells [AID590031, Type: Literature]
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21
[SID103245522]
Kd 0.0083Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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22
[SID103245522]
Kd 0.0083Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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23
[SID103245522]
Kd 0.0085Binding constant for ABL1(M351T) kinase domain [AID435514, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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24
[SID103245522]
Kd 0.0085Binding constant for ABL1(M351T) kinase domain [AID435514, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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25
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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26
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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27
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID435777, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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28
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID435777, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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29
[SID103245522]
IC50 0.0108Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assay [AID497611, Type: Literature]Tyrosine-protein kinase ABL1 [gi:59802613]
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30
[SID103245522]
Kd 0.011Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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31
[SID103245522]
Kd 0.011Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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32
[SID103245522]
Kd 0.012Binding constant for ABL1 kinase domain [AID435775, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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33
[SID103245522]
Kd 0.012Binding constant for ABL1 kinase domain [AID435775, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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34
[SID103245522]
Ki 0.013Inhibition of human recombinant Abl [AID317426, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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35
[SID103245522]
Ki 0.013Inhibition of human recombinant Abl [AID317426, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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36
[SID103245522]
Ki 0.013Inhibition of human recombinant Abl by filter-binding assay [AID370599, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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37
[SID103245522]
Ki 0.013Inhibition of human recombinant Abl by filter-binding assay [AID370599, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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38
[SID103245522]
Ki 0.013Inhibition of human recombinant c-Abl by filter-binding assay [AID595769, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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39
[SID103245522]
Ki 0.013Inhibition of human recombinant c-Abl by filter-binding assay [AID595769, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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40
[SID103245522]
IC50 0.013Cytotoxicity against human TF1 cells expressing c-KIT mutation assessed as cell viability [AID649625, Type: Literature]
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41
[SID103245522]
Kd 0.013Average Binding Constant for ABL2 ; NA=Not Active at 10 uM [AID256641, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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42
[SID103245522]
Kd 0.013Average Binding Constant for ABL2 ; NA=Not Active at 10 uM [AID256641, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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43
[SID103245522]
Kd 0.013Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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44
[SID103245522]
Kd 0.013Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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45
[SID103245522]
Kd 0.014Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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46
[SID103245522]
Kd 0.014Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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47
[SID103245522]
Kd 0.014Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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48
[SID103245522]
Kd 0.014Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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49
[SID103245522]
Kd 0.014Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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50
[SID103245522]
Kd 0.014Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View