Bookmark and Share
imatinib (CID 5291) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(505)
 
 
Inactive(413)
 
 
Inconclusive(56)
 
 
Unspecified(2185)
 
 
Top Targets:
PKc(97)
 
 
 
 
PKc like(85)
 
 
 
 
PTKc Abl(71)
 
 
 
 
STKc AGC(48)
 
 
 
 
PTKc Kit(33)
 
 
 
 
BioAssay Types:
Literature(2187)
 
 
 
 
 
Confirmatory(638)
 
 
 
 
 
Screening(12)
 
 
 
BioActivity Types:
Kd(882)
 
 
 
 
IC50(771)
 
 
 
 
Potency(114)
 
 
 
 
 
Ki(14)
 
 
 
EC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2845    Data Row: 3159   Total Pages: 158   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103245522]
Ki 3.08e-08Inhibition of PTK [AID442505, Type: Literature]
View
2
[SID103245522]
IC50 0.0002Cytotoxicity against human EOL-1 cells after 72 hrs by alamar-blue cell viability assay [AID414750, Type: Literature]
View
3
[SID103245522]
Kd 0.0007Binding constant for DDR1 kinase domain [AID435400, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
View
4
[SID103245522]
Kd 0.0007Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
View
5
[SID103245522]
IC50 0.0011Inhibition of wild type Bcr-Abl [AID463630, Type: Literature]
View
6
[SID103245522]
Kd 0.0011Binding constant for ABL1-non phosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
7
[SID103245522]
Kd 0.0018Binding constant for ABL1(Q252H)-non phosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
8
[SID103245522]
IC50 0.002Inhibition of PDGFRA (unknown origin) [AID767455, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
View
9
[SID103245522]
Kd 0.0022Average Binding Constant for ABL1; NA=Not Active at 10 uM [AID256665, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
10
[SID103245522]
Kd 0.0025Binding constant for ABL1(F317L)-non phosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
11
[SID103245522]
Kd 0.0059Binding constant for ABL1(H396P)-non phosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
12
[SID103245522]
Kd 0.006Binding affinity to human active site of N-terminal hexahistidine-tagged ABL2 expressed in Trichoplusia ni infected Sf9 cells by isothermal titration calorimetric assay [AID593557, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
13
[SID103245522]
IC50 0.00605Antiproliferative activity against human imatinib-resistant K562 cells [AID590031, Type: Literature]
View
14
[SID103245522]
Kd 0.0083Binding constant for ABL1(F317I)-non phosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
15
[SID103245522]
Kd 0.0085Binding constant for ABL1(M351T) kinase domain [AID435514, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
16
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID435777, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
17
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
18
[SID103245522]
GI50 0.01Inhibition of KIT in human GISTT1 cells assessed as growth inhibition after 72 hrs by SRB assay [AID759158, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
19
[SID103245522]
IC50 0.0108Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assay [AID497611, Type: Literature]Tyrosine-protein kinase ABL1 [gi:59802613]
View
20
[SID103245522]
Kd 0.011Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
View