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4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid (CID 5289501) - Compound BioActivity Data
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BioActivity Outcomes:
Active(117)
 
 
Inactive(834)
 
 
Inconclusive(75)
 
 
Unspecified(120)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
7TM GPCR Srsx(16)
 
 
ANK(14)
 
 
 
NR LBD TR(14)
 
 
 
PLDc mTdp1 2(13)
 
 
 
BioAssay Types:
Confirmatory(538)
 
 
 
 
 
Screening(353)
 
 
 
Literature(217)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(453)
 
 
 
 
 
EC50(29)
 
 
 
 
IC50(21)
 
 
 
 
 
AC50(8)
 
 
 
Kd(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 880    Data Row: 1146   Total Pages: 58   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174096]
ID50 2e-06Inhibitory dose against tracheal organ culture reversal of keratinization [AID210769, Type: Literature]
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2
[SID103174096]
ID50 3e-05Inhibitory effect of compound on the induction of ornithine decarboxylase in CD-1 mouse. [AID150874, Type: Literature]
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3
[SID103174096]
IC50 6e-05Inhibition of Chondrogenesis in day 11 embryonic limb bud cells [AID132681, Type: Literature]
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4
[SID103174096]
IC50 6e-05In vitro inhibition of chondrogenesis in mouse embryo limb bud cells [AID139988, Type: Literature]
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5
[SID103174096]
ED50 8e-05Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay [AID68786, Type: Literature]
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6
[SID103174096]
Ki 0.0005Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RA [AID220308, Type: confirmatory]
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7
[SID103174096]
Ki 0.0005Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA [AID220310, Type: confirmatory]
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8
[SID103174096]
AC50 0.00078In vitro promotion of plasminogen activator secretion from F9 (murine teratocarcinoma) cells. [AID68777, Type: Literature]
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9
[SID103174096]
ED50 0.0015Ability to displace [3H]all-trans-retinoic acid from F9 embryonal carcinoma cells, was assessed in a F9 laminin release assay [AID68787, Type: Literature]
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10
[SID103174096]
EC50 0.002Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells [AID199391, Type: Literature]
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11
[SID103174096]
EC50 0.002Transactivation potency for Retinoic acid receptor gamma [AID199034, Type: confirmatory]
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12
[SID46393539]
Kd 0.002Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Structure Of The Ligand Binding Domain Of The Retinoic Acid Receptor Beta [gi:56967051]
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13
[SID46393539]
Kd 0.002Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Structure Of The Ligand Binding Domain Of The Retinoic Acid Receptor Beta [gi:56967051]
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14
[SID103174096]
EC50 0.002Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay [AID198711, Type: confirmatory]Retinoic acid receptor gamma [gi:133498]
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15
[SID103174096]
EC50 0.0024Transcriptional activation of Retinoic acid receptor RAR gamma [AID198713, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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16
[SID103174096]
EC50 0.0024Transcriptional activation for RAR gamma receptor [AID166213, Type: confirmatory]
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17
[SID103174096]
EC50 0.0024Transcriptional activation of retinoic acid receptor RAR gamma [AID198896, Type: confirmatory]
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18
[SID103174096]
ED50 0.0025The ability to induce differentiation of human promyelocytic leukemia HL-60 cell line to mature granulocyte [AID80929, Type: Literature]
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19
[SID103174096]
EC50 0.003Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells [AID199386, Type: Literature]
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20
[SID103174096]
EC50 0.003Transactivation potency for Retinoic acid receptor beta [AID198523, Type: confirmatory]
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