4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid (CID 5289501) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(108)
 
 
Inactive(714)
 
 
Inconclusive(72)
 
 
Unspecified(120)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
NR LBD TR(14)
 
 
 
p450(13)
 
 
 
 
 
Tubulin-bindi..(12)
 
 
NR LBD RAR(11)
 
 
BioAssay Types:
Confirmatory(454)
 
 
 
 
 
Screening(296)
 
 
 
Literature(208)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(392)
 
 
 
 
 
EC50(29)
 
 
 
 
IC50(21)
 
 
 
 
 
Kd(6)
 
 
Ki(6)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 825    Data Row: 1014   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174096]
ID50 2e-06Inhibitory dose against tracheal organ culture reversal of keratinization [AID210769, Type: Literature]
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2
[SID103174096]
ID50 3e-05Inhibitory effect of compound on the induction of ornithine decarboxylase in CD-1 mouse. [AID150874, Type: Literature]
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3
[SID103174096]
IC50 6e-05Inhibition of Chondrogenesis in day 11 embryonic limb bud cells [AID132681, Type: Literature]
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4
[SID103174096]
IC50 6e-05In vitro inhibition of chondrogenesis in mouse embryo limb bud cells [AID139988, Type: Literature]
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5
[SID103174096]
ED50 8e-05Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay [AID68786, Type: Literature]
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6
[SID103174096]
Ki 0.0005Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RA [AID220308, Type: other]
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7
[SID103174096]
Ki 0.0005Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA [AID220310, Type: other]
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8
[SID103174096]
ED50 0.0015Ability to displace [3H]all-trans-retinoic acid from F9 embryonal carcinoma cells, was assessed in a F9 laminin release assay [AID68787, Type: Literature]
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9
[SID103174096]
EC50 0.002Transactivation potency for Retinoic acid receptor gamma [AID199034, Type: other]
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10
[SID103174096]
EC50 0.002Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells [AID199391, Type: Literature]
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11
[SID103174096]
EC50 0.002Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay [AID198711, Type: other]Retinoic acid receptor gamma [gi:133498]
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12
[SID103174096]
EC50 0.002Agonist activity for retinoic acid receptor RAR gamma in transcriptional activation assay [AID198711, Type: other]Retinoic acid receptor gamma [gi:133498]
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13
[SID103174096]
EC50 0.0024Transcriptional activation of Retinoic acid receptor RAR gamma [AID198713, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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14
[SID103174096]
EC50 0.0024Transcriptional activation of Retinoic acid receptor RAR gamma [AID198713, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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15
[SID103174096]
EC50 0.0024Transcriptional activation of retinoic acid receptor RAR gamma [AID198896, Type: other]
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16
[SID103174096]
EC50 0.0024Transcriptional activation for RAR gamma receptor [AID166213, Type: other]
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17
[SID103174096]
ED50 0.0025The ability to induce differentiation of human promyelocytic leukemia HL-60 cell line to mature granulocyte [AID80929, Type: Literature]
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18
[SID103174096]
EC50 0.003Transactivation potency for Retinoic acid receptor beta [AID198523, Type: other]
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19
[SID103174096]
EC50 0.003Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells [AID199386, Type: Literature]
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20
[SID103174096]
EC50 0.003Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay [AID198199, Type: other]Retinoic acid receptor beta [gi:17380507]
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21
[SID103174096]
EC50 0.003Agonist activity for retinoic acid receptor RAR beta in transcriptional activation assay [AID198199, Type: other]Retinoic acid receptor beta [gi:17380507]
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22
[SID103174096]
EC50 0.004Transcriptional activation of Retinoic acid receptor RAR beta [AID198201, Type: Literature]Retinoic acid receptor beta [gi:17380507]
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23
[SID103174096]
EC50 0.004Transcriptional activation of Retinoic acid receptor RAR beta [AID198201, Type: Literature]Retinoic acid receptor beta [gi:17380507]
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24
[SID103174096]
EC50 0.004Transcriptional activation of retinoic acid receptor RAR beta [AID198374, Type: other]
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25
[SID103174096]
EC50 0.004Transcriptional activation for RAR beta receptor [AID166209, Type: other]
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26
[SID103174096]
Kd 0.005Binding affinity for Retinoic acid receptor beta [AID198537, Type: other]
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27
[SID103174096]
Ki 0.005Binding affinity to retinoic acid receptor beta using [3H]CD 367 as radioligand [AID198222, Type: Literature]
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28
[SID103174096]
Ki 0.005Binding affinity to retinoic acid receptor (RAR) gamma using [3H]CD 367 as radioligand [AID198738, Type: Literature]
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29
[SID103174096]
IC50 0.005Binding affinity against retinoic Acid beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay [AID199387, Type: Literature]
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30
[SID103174096]
EC50 0.006Effective concentration against Retinoic acid receptor beta [AID198522, Type: Literature]
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31
[SID11113689]
Potency 0.0126qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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32
[SID103174096]
Ki 0.021Binding affinity to retinoic acid receptor alpha using [3H]CD 367 as radioligand [AID200139, Type: Literature]
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33
[SID103174096]
EC50 0.021Transcriptional activation of retinoic acid receptor RAR alpha [AID197919, Type: other]
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34
[SID103174096]
EC50 0.021Transcriptional activation for RAR alpha receptor [AID166205, Type: other]
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35
[SID103174096]
EC50 0.021Transcriptional activation of Retinoic acid receptor RAR alpha [AID200108, Type: Literature]Retinoic acid receptor alpha [gi:133483]
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36
[SID103174096]
EC50 0.021Transcriptional activation of Retinoic acid receptor RAR alpha [AID200108, Type: Literature]Retinoic acid receptor alpha [gi:133483]
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37
[SID103174096]
EC50 0.024Effective concentration against RAR-gamma receptor [AID166227, Type: Literature]
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38
[SID103174096]
Kd 0.026Binding affinity for Retinoic acid receptor gamma [AID199048, Type: other]
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39
[SID103174096]
IC50 0.026Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay [AID199392, Type: Literature]
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40
[SID103174096]
Kd 0.026Dissociation constant for Retinoic acid receptor gamma [AID254257, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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41
[SID103174096]
Kd 0.026Dissociation constant for Retinoic acid receptor gamma [AID254257, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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42
[SID103174096]
EC50 0.03Agonist activity for retinoic acid receptor RAR alpha in transcriptional activation assay [AID200106, Type: other]Retinoic acid receptor alpha [gi:133483]
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43
[SID103174096]
EC50 0.03Agonist activity for retinoic acid receptor RAR alpha in transcriptional activation assay [AID200106, Type: other]Retinoic acid receptor alpha [gi:133483]
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44
[SID103174096]
EC50 0.03Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells [AID197922, Type: Literature]
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45
[SID103174096]
EC50 0.03Transactivation potency for Retinoic acid receptor alpha [AID198033, Type: other]
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46
[SID103174096]
IC50 0.036Binding affinity against retinoic Acid alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay [AID198042, Type: Literature]
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47
[SID103174096]
Kd 0.036Binding affinity for Retinoic acid receptor alpha [AID198047, Type: other]
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48
[SID103174096]
EC50 0.085Effective concentration against RAR-alpha receptor [AID166217, Type: Literature]
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49
[SID26751881]
Potency 0.7079qHTS assay for small molecule agonists of retinoid X receptor alpha signaling [AID588544, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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50
[SID26751881]
Potency 0.7079qHTS assay for small molecule agonists of retinoid X receptor alpha signaling [AID588544, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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