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Morphine (CID 5288826) - Compound BioActivity Data
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BioActivity Outcomes:
Active(367)
 
 
Inactive(23)
 
 
Inconclusive(37)
 
 
Unspecified(653)
 
 
Top Targets:
7TM GPCR Srx(160)
 
 
 
 
7TM GPCR Srsx(47)
 
 
 
 
GT1 Gtf like(15)
 
 
ABC MTABC3 MD..(9)
 
 
 
p450(7)
 
 
 
BioAssay Types:
Literature(1052)
 
 
 
 
 
Confirmatory(10)
 
 
 
BioActivity Types:
Ki(184)
 
 
 
 
IC50(130)
 
 
 
 
EC50(36)
 
 
 
Kd(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1058    Data Row: 1080   Total Pages: 54   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169185]
IC50 2.7e-0550% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate [AID145933, Type: Literature]
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2
[SID103169185]
Ki 9e-05Antinociceptive activity determined in vivo in tail flick assay in male Swiss mice with 2.0 mg/kg Naloxone [AID221723, Type: Literature]
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3
[SID103169185]
Ki 0.00013Antinociceptive activity determined in vivo in tail flick assay in male Swiss mice with 0.2 mg/kg Naloxone [AID125446, Type: Literature]
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4
[SID103169185]
IC50 0.00013Inhibitory activity of compound in guinea pig ileum tissue [AID76209, Type: Literature]
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5
[SID103169185]
IC50 0.00014Inhibition of [3H]DAMGO radioligand binding to rat brain opioid receptor mu 1. [AID151440, Type: Literature]
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6
[SID103169185]
Ki 0.00014Displacement of [3H]DAMGO from mu-opioid receptor expressed in CHOK1 cells after overnight incubation by scintillation proximity assay [AID695711, Type: Literature]
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7
[SID103169185]
Ki 0.0005Binding affinity towards opioid receptor mu 1 [AID149449, Type: Literature]
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8
[SID103169185]
IC50 0.00057In vitro binding affinity against cloned human Opioid receptor mu 1 expressed in HEK 293S cells [AID150822, Type: Literature]
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9
[SID103169185]
Ki 0.00078mu-1 receptor binding affinity in rat brain by 3H [d-Ala2, d-Leu5] enkephalin displacement. [AID151912, Type: Literature]
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10
[SID103169185]
Ki 0.00088Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of Chinese hamster ovary membrane [AID148328, Type: Literature]
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11
[SID103169185]
Ki 0.00088Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes. [AID148028, Type: Literature]Mu-type opioid receptor [gi:3024265]
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12
[SID103169185]
Ki 0.00088Binding affinity towards Opioid receptor mu 1 of guinea pig brain membranes using radioligand 0.25 nM [3H]DAMGO [AID148030, Type: Literature]Mu-type opioid receptor [gi:3024265]
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13
[SID103169185]
Ki 0.00088Displacement of [3H]DAMGO form mu opioid receptor in guinea pig brain [AID410723, Type: Literature]Mu-type opioid receptor [gi:3024265]
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14
[SID103169185]
Ki 0.00088Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells [AID259394, Type: Literature]Mu-type opioid receptor [gi:2851402]
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15
[SID103169185]
Ki 0.00088Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]Mu-type opioid receptor [gi:2851402]
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16
[SID103169185]
Ki 0.0009Activity was evaluated by inhibition of the binding of 0.8 nM [3H]- DAMGO at Opioid receptor mu 1 binding site [AID149447, Type: Literature]
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17
[SID103169185]
Ki 0.001Inhibition of [3H]DAMGO binding to mu opioid receptor of rat brain membranes [AID151606, Type: Literature]Mu-type opioid receptor [gi:464314]
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18
[SID103169185]
Ki 0.001Antinociceptive activity determined in vivo in tail flick assay in male Swiss mice with saline [AID134210, Type: Literature]
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19
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation counting [AID603730, Type: Literature]Mu-type opioid receptor [gi:3024265]
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20
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
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