Morphine (CID 5288826) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(313)
 
 
Inactive(18)
 
 
Inconclusive(32)
 
 
Unspecified(575)
 
 
Top Targets:
7TM GPCR Srx(91)
 
 
 
 
GT1 Gtf like(15)
 
 
7TM GPCR Srv(6)
 
 
 
MFS(2)
 
 
 
ABC MTABC3 MD..(1)
 
 
BioAssay Types:
Literature(903)
 
 
 
 
 
BioActivity Types:
Ki(166)
 
 
 
 
IC50(114)
 
 
 
 
EC50(26)
 
 
Kd(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 938    Data Row: 938   Total Pages: 19   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169185]
IC50 2.7e-0550% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate [AID145933, Type: Literature]
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2
[SID103169185]
Ki 9e-05Antinociceptive activity determined in vivo in tail flick assay in male Swiss mice with 2.0 mg/kg Naloxone [AID221723, Type: Literature]
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3
[SID103169185]
IC50 0.00013Inhibitory activity of compound in guinea pig ileum tissue [AID76209, Type: Literature]
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4
[SID103169185]
Ki 0.00013Antinociceptive activity determined in vivo in tail flick assay in male Swiss mice with 0.2 mg/kg Naloxone [AID125446, Type: Literature]
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5
[SID103169185]
IC50 0.00014Inhibition of [3H]DAMGO radioligand binding to rat brain opioid receptor mu 1. [AID151440, Type: Literature]
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6
[SID103169185]
Ki 0.0005Binding affinity towards opioid receptor mu 1 [AID149449, Type: Literature]
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7
[SID103169185]
IC50 0.00057In vitro binding affinity against cloned human Opioid receptor mu 1 expressed in HEK 293S cells [AID150822, Type: Literature]
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8
[SID103169185]
Ki 0.00078mu-1 receptor binding affinity in rat brain by 3H [d-Ala2, d-Leu5] enkephalin displacement. [AID151912, Type: Literature]
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9
[SID103169185]
Ki 0.00088Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of Chinese hamster ovary membrane [AID148328, Type: Literature]
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10
[SID103169185]
Ki 0.00088Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes. [AID148028, Type: Literature]
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11
[SID103169185]
Ki 0.00088Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]
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12
[SID103169185]
Ki 0.00088Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells [AID259394, Type: Literature]Mu-type opioid receptor [gi:2851402]
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13
[SID103169185]
Ki 0.00088Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells [AID259394, Type: Literature]Mu-type opioid receptor [gi:2851402]
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14
[SID103169185]
Ki 0.00088Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells [AID259394, Type: Literature]Mu-type opioid receptor [gi:2851402]
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15
[SID103169185]
Ki 0.00088Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells [AID259394, Type: Literature]Mu-type opioid receptor [gi:2851402]
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16
[SID103169185]
Ki 0.00088Displacement of [3H]DAMGO form mu opioid receptor in guinea pig brain [AID410723, Type: Literature]Mu-type opioid receptor [gi:3024265]
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17
[SID103169185]
Ki 0.0009Activity was evaluated by inhibition of the binding of 0.8 nM [3H]- DAMGO at Opioid receptor mu 1 binding site [AID149447, Type: Literature]
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18
[SID103169185]
Ki 0.001Antinociceptive activity determined in vivo in tail flick assay in male Swiss mice with saline [AID134210, Type: Literature]
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19
[SID103169185]
Ki 0.001Binding affinity of compound evaluated for Opioid receptor mu 1 isolated from rat brain [AID151606, Type: Literature]
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20
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation counting [AID603730, Type: Literature]Mu-type opioid receptor [gi:3024265]
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21
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cells [AID269569, Type: Literature]Mu-type opioid receptor [gi:2851402]
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22
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cells [AID269569, Type: Literature]Mu-type opioid receptor [gi:2851402]
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23
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cells [AID269569, Type: Literature]Mu-type opioid receptor [gi:2851402]
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24
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cells [AID269569, Type: Literature]Mu-type opioid receptor [gi:2851402]
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25
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
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26
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
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27
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
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28
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
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29
[SID103169185]
IC50 0.00127Displacement of [3H]DAMGO from mu opioid receptor in ICR mouse whole brain [AID383161, Type: Literature]Mu-type opioid receptor [gi:1171911]
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30
[SID103169185]
IC50 0.00127Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellum [AID411134, Type: Literature]Mu-type opioid receptor [gi:1171911]
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31
[SID103169185]
IC50 0.0016Opioid receptor activity in terms of inhibition of [3H]dihydromorphine binding in rat brain membrane [AID149177, Type: Literature]
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32
[SID103169185]
Ki 0.0017Displacement of [3H]diprenorphine from recombinant mu opioid receptor expressed in C6 cells [AID330420, Type: Literature]
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33
[SID103169185]
Ki 0.0018Binding affinity against mu opioid receptor in mouse hot plate test [AID238659, Type: Literature]Mu-type opioid receptor [gi:1171911]
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34
[SID103169185]
Ki 0.0018Displacement of [3H]DPDPE from delta opioid receptor in rat brain membranes [AID601797, Type: Literature]Delta-type opioid receptor [gi:464311]
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35
[SID103169185]
Ki 0.0018Binding affinity for the Opioid receptor mu 1 [AID147910, Type: Literature]
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36
[SID103169185]
Ki 0.0018Binding affinity by inhibition of [3H]DAMGO binding to Opioid receptor mu 1 from rat brain membranes [AID151742, Type: Literature]
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37
[SID103169185]
Ki 0.0018Inhibition of binding of [3H]DAMGO to opioid receptor mu 1 from rat brain membrane. [AID151890, Type: Literature]
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38
[SID103169185]
Ki 0.0018Binding affinity towards mu opioid receptor was determined [AID152074, Type: Literature]
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39
[SID103169185]
IC50 0.00182Inhibition of [3H]U-69593 radioligand binding to Guinea pig opioid receptor kappa 1. [AID148680, Type: Literature]
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40
[SID103169185]
Ki 0.00192Displacement of [125I]-IBOxyA from MOR-1 expressed in CHO cells [AID603171, Type: Literature]
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41
[SID103169185]
IC50 0.00194Inhibition of [3H]- DAMGO binding to Rat brain Opioid receptor mu 1 [AID151303, Type: Literature]Mu-type opioid receptor [gi:464314]
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42
[SID103169185]
Ki 0.00198Displacement of [3H]-DAMGO from mu opioid receptor in guinea pig forebrain homogenates [AID603511, Type: Literature]Mu-type opioid receptor [gi:3024265]
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43
[SID103169185]
Ki 0.002Compound was evaluated for binding affinity towards mu-specific opiate receptor from combinatorial peptoid library [AID141657, Type: Literature]
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44
[SID103169185]
Ki 0.002Displacement of [3H]naloxone from opioid receptor in Sprague-Dawley rat striatal membrane by scintillation spectrophotometry [AID399187, Type: Literature]
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45
[SID103169185]
Ki 0.0021Ability to displace [3H]naloxone from the Opioid receptor mu 1 isolated from the rat brain membranes. [AID151590, Type: Literature]
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46
[SID103169185]
Ki 0.00215Inhibition of [3H]DAGO binding to mu 1 opioid receptor in rat brain membranes [AID151592, Type: Literature]
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47
[SID103169185]
Ki 0.0022Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membranes [AID601796, Type: Literature]Mu-type opioid receptor [gi:3024265]
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48
[SID103169185]
Ki 0.0022Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK-293 cells by scintillation counting [AID669684, Type: other]
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49
[SID103169185]
Ki 0.0025Binding affinity towards opioid receptor mu 2 [AID152210, Type: Literature]Mu-type opioid receptor [gi:6093615]
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50
[SID103169185]
Ki 0.0025Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brain [AID268677, Type: Literature]Mu-type opioid receptor [gi:3024265]
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