Fenretinide (CID 5288209) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(285)
 
 
Top Targets:
Lipocalin(5)
 
 
NR LBD ROR li..(3)
 
 
LsmAD(3)
 
 
ALDH F1AB F2..(2)
 
 
CD36(2)
 
 
BioAssay Types:
Confirmatory(123)
 
 
Literature(69)
 
 
Screening(22)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(87)
 
 
IC50(21)
 
 
EC50(6)
 
 
Kd(3)
 
 
AC50(2)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 179    Data Row: 285   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164483]
ED50 0.0003Reversal of keratinization in vitamin A deficient hamster trachea culture [AID84861, Type: Literature]
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2
[SID103164483]
IC50 0.15Growth inhibition of human MCF7 cells after 6 days by MTT assay [AID282372, Type: Literature]
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3
[SID103164483]
Kd 0.17Dissociation constant with retinol binding protein was determined [AID199394, Type: Literature]
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4
[SID103164483]
EC50 0.204Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay [AID521214, Type: Literature]
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5
[SID103164483]
EC50 0.334Antiproliferative activity against mouse neural precursor cells by MTT assay [AID521208, Type: Literature]
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6
[SID49718105]
AC50 1.039Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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7
[SID49718105]
AC50 2.256Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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8
[SID103164483]
EC50 2.372Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein interaction after 2 hr by TR-FRET assay [AID606066, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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9
[SID103164483]
EC50 2.399Antiproliferative activity against mouse astrocyte cells by MTT assay [AID521209, Type: Literature]
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10
[SID103164483]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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11
[SID50105428]
Potency 3.5481qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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12
[SID103164483]
IC50 3.6Growth inhibition of human PC3 cells after 6 days by MTT assay [AID282377, Type: Literature]
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13
[SID103164483]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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14
[SID50105428]
Potency 3.9811qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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15
[SID50105428]
Potency 4.0533S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]Pmp22 gene product [Rattus norvegicus] [gi:8393992]
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16
[SID50105427]
Potency 4.4668qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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17
[SID103164483]
IC50 5Cytotoxicity against human G401 cells assessed as cell survival after 3 days by MTS assay [AID344003, Type: Literature]
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18
[SID103164483]
IC50 5Cytotoxicity against human STM cells assessed as cell survival after 3 days by MTS assay [AID344004, Type: Literature]
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19
[SID50105427]
Potency 5.0119VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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20
[SID103164483]
IC50 6Cytotoxicity against human HuCCT1 cells after 72 hrs by MTT assay [AID654488, Type: Literature]
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21
[SID92763796]
Potency 6.3096qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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22
[SID17389243]
Potency 6.3096qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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23
[SID17389243]
Potency 6.3096qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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24
[SID17389243]
Potency 6.3096qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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25
[SID17389243]
Potency 6.3096qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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26
[SID50105428]
Potency 6.3096qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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27
[SID49718105]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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28
[SID103164483]
IC50 7Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay [AID654487, Type: Literature]
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29
[SID103164483]
IC50 7.5Growth inhibition of human LNCaP cells after 6 days by MTT assay [AID282376, Type: Literature]
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30
[SID103164483]
IC50 7.7Growth inhibition of human MDA-MB-231 cells after 6 days by MTT assay [AID282374, Type: Literature]
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31
[SID103164483]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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32
[SID26752781]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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33
[SID49718105]
EC50 8.45Dose response counterscreen for uHTS small molecule activators of the adaptive arm of the Unfolded Protein Response via a luminescent-based reporter assay [AID489027, Type: confirmatory]
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34
[SID26752781]
Potency 8.9125Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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35
[SID26752783]
Potency 8.9125qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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36
[SID26752783]
Potency 8.9125qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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37
[SID103164483]
IC50 9Cytotoxicity against human MON cells after 3 days by MTS assay [AID406759, Type: Literature]
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38
[SID17389243]
Potency 10qHTS Assay for Identification of Small Molecule Antagonists for Thrombopoietin (TPO) Signaling Pathway [AID918, Type: confirmatory]Thrombopoietin [Homo sapiens] [gi:120660324]
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39
[SID103164483]
IC50 10Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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40
[SID103164483]
IC50 10Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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41
[SID92763796]
Potency 10qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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42
[SID103164483]
IC50 10Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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43
[SID103164483]
IC50 10Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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44
[SID49718105]
Potency 10qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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45
[SID26752781]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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46
[SID144204558]
Potency 10.5931qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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47
[SID50105428]
Potency 11.2117S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]Pmp22 gene product [Rattus norvegicus] [gi:8393992]
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48
[SID50105428]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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49
[SID50105428]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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50
[SID50105427]
Potency 11.2202Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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