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Fenretinide (CID 5288209) - Compound BioActivity Data
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BioActivity Outcomes:
Active(338)
 
 
Inactive(1097)
 
 
Inconclusive(359)
 
 
Unspecified(68)
 
 
Top Targets:
7TM GPCR Srx(37)
 
 
 
7TM GPCR Srsx(29)
 
 
 
NR LBD PPAR(21)
 
 
 
 
NR LBD TR(20)
 
 
 
 
NR LBD ER(17)
 
 
 
 
BioAssay Types:
Confirmatory(873)
 
 
 
 
 
Screening(526)
 
 
 
 
Literature(214)
 
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(779)
 
 
 
 
 
IC50(39)
 
 
 
 
 
EC50(9)
 
 
 
 
Kd(4)
 
 
Ki(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 990    Data Row: 1862   Total Pages: 94   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164483]
ED50 0.0003Reversal of keratinization in vitamin A deficient hamster trachea culture [AID84861, Type: Literature]
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2
[SID103164483]
IC50 0.15Growth inhibition of human MCF7 cells after 6 days by MTT assay [AID282372, Type: Literature]
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3
[SID103164483]
Kd 0.156Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis [AID606062, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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4
[SID103164483]
Kd 0.17Dissociation constant with retinol binding protein was determined [AID199394, Type: Literature]
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5
[SID103164483]
EC50 0.204Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay [AID521214, Type: Literature]
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6
[SID103164483]
EC50 0.334Antiproliferative activity against mouse neural precursor cells by MTT assay [AID521208, Type: Literature]
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7
[SID49718105]
AC50_uM 1.039Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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8
[SID49718105]
AC50_uM 2.256Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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9
[SID103164483]
EC50 2.372Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein interaction after 2 hr by TR-FRET assay [AID606066, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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10
[SID103164483]
EC50 2.399Antiproliferative activity against mouse astrocyte cells by MTT assay [AID521209, Type: Literature]
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11
[SID144208187]
Potency-Replicate_1 2.8002qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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12
[SID144204558]
Ratio Potency (uM) 2.91555qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID103164483]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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14
[SID144204558]
Potency-Replicate_1 3.3491qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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15
[SID50105428]
Potency 3.5481qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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16
[SID144208187]
Potency-Replicate_1 3.5567qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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17
[SID103164483]
IC50 3.6Growth inhibition of human PC3 cells after 6 days by MTT assay [AID282377, Type: Literature]
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18
[SID144208187]
Ratio Potency (uM) 3.95535qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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19
[SID103164483]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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20
[SID50105428]
Potency 3.9811qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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