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Fenretinide (CID 5288209) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(341)
 
 
Inactive(1071)
 
 
Inconclusive(356)
 
 
Unspecified(47)
 
 
Top Targets:
7TM GPCR Srx(37)
 
 
 
7TM GPCR Srsx(29)
 
 
 
NR LBD PPAR(21)
 
 
 
 
NR LBD TR(20)
 
 
 
 
NR LBD ER(17)
 
 
 
 
BioAssay Types:
Confirmatory(869)
 
 
 
 
 
Screening(522)
 
 
 
 
Literature(176)
 
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(772)
 
 
 
 
 
IC50(39)
 
 
 
 
 
EC50(9)
 
 
 
 
Ki(4)
 
 
Kd(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 959    Data Row: 1815   Total Pages: 37   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164483]
ED50 0.0003Reversal of keratinization in vitamin A deficient hamster trachea culture [AID84861, Type: Literature]
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2
[SID103164483]
IC50 0.15Growth inhibition of human MCF7 cells after 6 days by MTT assay [AID282372, Type: Literature]
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3
[SID103164483]
Kd 0.17Dissociation constant with retinol binding protein was determined [AID199394, Type: Literature]
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4
[SID103164483]
EC50 0.204Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay [AID521214, Type: Literature]
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5
[SID103164483]
EC50 0.334Antiproliferative activity against mouse neural precursor cells by MTT assay [AID521208, Type: Literature]
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6
[SID49718105]
AC50_uM 1.039Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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7
[SID49718105]
AC50_uM 2.256Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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8
[SID103164483]
EC50 2.372Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein interaction after 2 hr by TR-FRET assay [AID606066, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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9
[SID103164483]
EC50 2.399Antiproliferative activity against mouse astrocyte cells by MTT assay [AID521209, Type: Literature]
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10
[SID144208187]
Potency-Replicate_1 2.8002qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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11
[SID144204558]
Ratio Potency (uM) 2.91555qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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12
[SID103164483]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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13
[SID144204558]
Potency-Replicate_1 3.3491qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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14
[SID50105428]
Potency 3.5481qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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15
[SID144208187]
Potency-Replicate_1 3.5567qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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16
[SID103164483]
IC50 3.6Growth inhibition of human PC3 cells after 6 days by MTT assay [AID282377, Type: Literature]
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17
[SID144208187]
Ratio Potency (uM) 3.95535qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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18
[SID103164483]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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19
[SID50105428]
Potency 3.9811qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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20
[SID50105428]
Potency 4.0533S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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21
[SID50105427]
Potency 4.4668qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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22
[SID170466359]
Potency-Replicate_1 4.7304qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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23
[SID103164483]
IC50 5Cytotoxicity against human G401 cells assessed as cell survival after 3 days by MTS assay [AID344003, Type: Literature]
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24
[SID103164483]
IC50 5Cytotoxicity against human STM cells assessed as cell survival after 3 days by MTS assay [AID344004, Type: Literature]
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25
[SID50105427]
Potency 5.0119VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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26
[SID144204558]
Potency-Replicate_1 5.9557qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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27
[SID103164483]
IC50 6Cytotoxicity against human HuCCT1 cells after 72 hrs by MTT assay [AID654488, Type: Literature]
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28
[SID144204558]
Potency-Replicate_1 6.007qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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29
[SID92763796]
Potency 6.3096qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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30
[SID50105428]
Potency 6.3096qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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31
[SID17389243]
Potency 6.3096qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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32
[SID49718105]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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33
[SID144204558]
Potency-Replicate_1 6.6824qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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34
[SID103164483]
IC50 7Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay [AID654487, Type: Literature]
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35
[SID26752781]
Potency 7.0795qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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36
[SID103164483]
IC50 7.5Growth inhibition of human LNCaP cells after 6 days by MTT assay [AID282376, Type: Literature]
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37
[SID103164483]
IC50 7.7Growth inhibition of human MDA-MB-231 cells after 6 days by MTT assay [AID282374, Type: Literature]
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38
[SID144208187]
Potency-Replicate_1 7.892qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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39
[SID103164483]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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40
[SID26752781]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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41
[SID170466359]
Potency-Replicate_1 8.412qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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42
[SID49718105]
EC50_Mean 8.45Dose response counterscreen for uHTS small molecule activators of the adaptive arm of the Unfolded Protein Response via a luminescent-based reporter assay [AID489027, Type: confirmatory]
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43
[SID144208187]
Potency-Replicate_1 8.8549qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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44
[SID26752781]
Potency 8.9125Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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45
[SID144208187]
Ratio Potency (uM) 8.9339qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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46
[SID103164483]
IC50 9Cytotoxicity against human MON cells after 3 days by MTS assay [AID406759, Type: Literature]
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47
[SID170466359]
Potency-Replicate_1 9.4384qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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48
[SID144204558]
Potency-Replicate_1 9.4392qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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49
[SID144204558]
Potency-Replicate_1 9.4392qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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50
[SID144204558]
Ratio Potency (uM) 9.52052qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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