alvocidib (CID 5287969) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(457)
 
 
Inactive(100)
 
 
Unspecified(571)
 
 
Top Targets:
PKc(106)
 
 
 
 
PKc like(70)
 
 
 
 
STKc AGC(62)
 
 
 
 
PTKc Abl(32)
 
 
 
 
PTKc EGFR(23)
 
 
 
 
BioAssay Types:
Literature(1117)
 
 
 
 
BioActivity Types:
Kd(879)
 
 
 
 
IC50(105)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1127    Data Row: 1128   Total Pages: 23   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234154]
Kd 0.00069Binding constant for ICK kinase domain [AID625090, Type: Literature]Serine/threonine-protein kinase ICK [gi:48428273]
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2
[SID104234154]
Kd 0.0033Binding constant for CDK4-cyclinD3 kinase domain [AID624781, Type: Literature]Cyclin-dependent kinase 4 [gi:1168867]
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3
[SID104234154]
Kd 0.0064Binding constant for CDK9 kinase domain [AID624830, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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4
[SID104234154]
Kd 0.0064Binding constant for CDK9 kinase domain [AID624830, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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5
[SID104234154]
Kd 0.0064Binding constant for full-length CDK9 [AID435279, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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6
[SID104234154]
Kd 0.0064Binding constant for full-length CDK9 [AID435279, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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7
[SID104234154]
IC50 0.007Antiproliferative activity against ID8 cells [AID284848, Type: Literature]
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8
[SID104234154]
Kd 0.0071Binding constant for CDKL5 kinase domain [AID624905, Type: Literature]Cyclin-dependent kinase-like 5 [gi:6175070]
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9
[SID104234154]
Kd 0.009Binding constant for CDK4-cyclinD1 kinase domain [AID624780, Type: Literature]Cyclin-dependent kinase 4 [gi:1168867]
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10
[SID104234154]
IC50 0.012Inhibition of recombinant cyclin A/CDK2 expressed in Sf9 cells [AID310153, Type: Literature]
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11
[SID104234154]
IC50 0.016Inhibition of LNCaP human prostate carcinoma cell proliferation [AID100381, Type: Literature]
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12
[SID104234154]
IC50 0.017Inhibition of HCT116 / VP35 human colon carcinoma cell proliferation [AID81688, Type: Literature]
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13
[SID104234154]
IC50 0.018Inhibition of HCT116 human colon carcinoma cell proliferation [AID79014, Type: Literature]
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14
[SID104234154]
Kd 0.019Average Binding Constant for CAMKK1 ; NA=Not Active at 10 uM [AID256583, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 1 [gi:56404620]
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15
[SID104234154]
Kd 0.019Average Binding Constant for CAMKK1 ; NA=Not Active at 10 uM [AID256583, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 1 [gi:56404620]
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16
[SID104234154]
IC50 0.02Inhibition of cdk9 [AID503749, Type: Literature]
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17
[SID104234154]
IC50 0.021Inhibition of HCT116 / VM46 human colon carcinoma cell proliferation [AID81687, Type: Literature]
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18
[SID104234154]
Kd 0.023Binding constant for full-length CDK7 [AID435278, Type: Literature]Cyclin-dependent kinase 7 [gi:1705722]
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19
[SID104234154]
Kd 0.023Binding constant for full-length CDK7 [AID435278, Type: Literature]Cyclin-dependent kinase 7 [gi:1705722]
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20
[SID104234154]
Kd 0.023Binding constant for CDK7 kinase domain [AID624845, Type: Literature]Cyclin-dependent kinase 7 [gi:1705722]
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21
[SID104234154]
Kd 0.023Binding constant for CDK7 kinase domain [AID624845, Type: Literature]Cyclin-dependent kinase 7 [gi:1705722]
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22
[SID104234154]
IC50 0.026Antiproliferative activity against MCF7 cells [AID284849, Type: Literature]
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23
[SID104234154]
Kd 0.028Binding constant for MAK kinase domain [AID625025, Type: Literature]Serine/threonine-protein kinase MAK [gi:13432166]
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24
[SID104234154]
IC50 0.03Inhibition of CDK1 [AID512723, Type: Literature]
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25
[SID104234154]
IC50 0.03Inhibition of cdk1 [AID503752, Type: Literature]
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26
[SID104234154]
IC50 0.03Inhibitory activity against baculovirus expressed Cyclin dependent kinase 1-cyclinB [AID55520, Type: other]
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27
[SID104234154]
IC50 0.03Inhibition of cyclin-dependent kinase 1-cyclin B [AID53348, Type: Literature]
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28
[SID104234154]
IC50 0.03Inhibitory concentration against CDK1/cyclin B was determined [AID53349, Type: Literature]
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29
[SID104234154]
IC50 0.03Inhibition of Cyclin-dependent kinase 1-cyclin B1 [AID53351, Type: Literature]G2/mitotic-specific cyclin-B [gi:116176]
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30
[SID104234154]
IC50 0.03Inhibition of Cyclin-dependent kinase 1-cyclin B1 [AID53351, Type: Literature]G2/mitotic-specific cyclin-B [gi:116176]
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31
[SID104234154]
IC50 0.03Inhibition of Cyclin-dependent kinase 1-cyclin B1 [AID53351, Type: Literature]G2/mitotic-specific cyclin-B [gi:116176]
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32
[SID104234154]
IC50 0.03Inhibition of human GST-CDK1/cyclin B1 expressed in baculovirus using [gamma-33P]ATP after 45 mins by liquid scintillation counting [AID511077, Type: Literature]G2/mitotic-specific cyclin-B [gi:116176]
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33
[SID104234154]
IC50 0.03Inhibition of human GST-CDK1/cyclin B1 expressed in baculovirus using [gamma-33P]ATP after 45 mins by liquid scintillation counting [AID511077, Type: Literature]G2/mitotic-specific cyclin-B [gi:116176]
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34
[SID104234154]
IC50 0.03Inhibition of human GST-CDK1/cyclin B1 expressed in baculovirus using [gamma-33P]ATP after 45 mins by liquid scintillation counting [AID511077, Type: Literature]G2/mitotic-specific cyclin-B [gi:116176]
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35
[SID104234154]
Kd 0.035Binding constant for TYK2(JH2domain-pseudokinase) kinase domain [AID624913, Type: Literature]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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36
[SID104234154]
Kd 0.035Binding constant for TYK2(JH2domain-pseudokinase) kinase domain [AID624913, Type: Literature]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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37
[SID104234154]
Kd 0.035Binding constant for TYK2(JH2domain-pseudokinase) kinase domain [AID624913, Type: Literature]Non-receptor tyrosine-protein kinase TYK [gi:56405328]
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38
[SID104234154]
IC50 0.038Inhibition of A2780 / DDP-R human ovarian carcinoma cell proliferation [AID9823, Type: Literature]
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39
[SID104234154]
IC50 0.04Inhibition of cdk2 [AID503751, Type: Literature]
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40
[SID104234154]
Kd 0.043Average Binding Constant for CDK5 ; NA=Not Active at 10 uM [AID256616, Type: Literature]Cyclin-dependent kinase 5 [gi:4033704]
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41
[SID104234154]
Kd 0.043Average Binding Constant for CDK5 ; NA=Not Active at 10 uM [AID256616, Type: Literature]Cyclin-dependent kinase 5 [gi:4033704]
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42
[SID104234154]
Kd 0.043Average Binding Constant for CDK5 ; NA=Not Active at 10 uM [AID256616, Type: Literature]Cyclin-dependent kinase 5 [gi:4033704]
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43
[SID104234154]
Kd 0.043Average Binding Constant for CDK5 ; NA=Not Active at 10 uM [AID256616, Type: Literature]Cyclin-dependent kinase 5 [gi:4033704]
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44
[SID104234154]
IC50 0.045Inhibition of ABAE human fibroblast cell proliferation [AID9845, Type: Literature]
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45
[SID104234154]
IC50 0.046Inhibition of HL60 human leukemia cell proliferation [AID82807, Type: Literature]
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46
[SID104234154]
IC50 0.05Inhibition of Cyclin-dependent kinase 1-cyclin A [AID53189, Type: other]
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47
[SID104234154]
IC50 0.051Inhibition of Hs 27 human fibroblast cell proliferation [AID85231, Type: other]
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48
[SID104234154]
IC50 0.052Inhibition of CCRF-CEM human leukemia cell proliferation [AID43366, Type: Literature]
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49
[SID104234154]
IC50 0.054Inhibition of OVCAR-3 human ovarian carcinoma cell proliferation [AID145408, Type: Literature]
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50
[SID104234154]
Kd 0.055Binding constant for TNNI3K kinase domain [AID625097, Type: Literature]Serine/threonine-protein kinase TNNI3K [gi:300669705]
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