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alvocidib (CID 5287969) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(530)
 
 
Inactive(103)
 
 
Unspecified(599)
 
 
Top Targets:
PTKc Abl(32)
 
 
 
 
STKc CDK2 3(23)
 
 
 
CYCLIN(23)
 
 
 
PTKc EGFR(23)
 
 
 
 
PKc like(19)
 
 
 
 
BioAssay Types:
Literature(1198)
 
 
 
 
Confirmatory(2)
 
 
 
BioActivity Types:
Kd(879)
 
 
 
 
IC50(144)
 
 
 
Ki(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1199    Data Row: 1232   Total Pages: 62   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234154]
Kd 0.00069Binding constant for ICK kinase domain [AID625090, Type: Literature]Serine/threonine-protein kinase ICK [gi:48428273]
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2
[SID104234154]
Ki 0.003Inhibition of CDK9/Cyclin T (1 to 330 amino acid residues) (unknown origin) by differential scanning fluorimetry assay [AID723735, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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3
[SID104234154]
Ki 0.003Inhibition of CDK9 (unknown origin) [AID723739, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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4
[SID104234154]
Ki 0.003Inhibition of CDK9/Cyclin T (1 to 330 amino acid residues) (unknown origin) by differential scanning fluorimetry assay [AID723735, Type: Literature]Cyclin-T1 [gi:9296942]
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5
[SID104234154]
Kd 0.0033Binding constant for CDK4-cyclinD3 kinase domain [AID624781, Type: Literature]Cyclin-dependent kinase 4 [gi:1168867]
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6
[SID104234154]
Kd 0.0064Binding constant for full-length CDK9 [AID435279, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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7
[SID104234154]
Kd 0.0064Binding constant for CDK9 kinase domain [AID624830, Type: Literature]Cyclin-dependent kinase 9 [gi:68067660]
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8
[SID104234154]
IC50 0.007Antiproliferative activity against ID8 cells [AID284848, Type: Literature]
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9
[SID104234154]
Kd 0.0071Binding constant for CDKL5 kinase domain [AID624905, Type: Literature]Cyclin-dependent kinase-like 5 [gi:6175070]
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10
[SID104234154]
Kd 0.009Binding constant for CDK4-cyclinD1 kinase domain [AID624780, Type: Literature]Cyclin-dependent kinase 4 [gi:1168867]
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11
[SID104234154]
IC50 0.012Inhibition of recombinant cyclin A/CDK2 expressed in Sf9 cells [AID310153, Type: Literature]
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12
[SID104234154]
IC50 0.016Inhibition of LNCaP human prostate carcinoma cell proliferation [AID100381, Type: Literature]
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13
[SID104234154]
IC50 0.017Inhibition of HCT116 / VP35 human colon carcinoma cell proliferation [AID81688, Type: Literature]
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14
[SID104234154]
IC50 0.018Inhibition of HCT116 human colon carcinoma cell proliferation [AID79014, Type: Literature]
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15
[SID104234154]
Kd 0.019Average Binding Constant for CAMKK1; NA=Not Active at 10 uM [AID256583, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 1 [gi:56404620]
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16
[SID104234154]
IC50 0.02Inhibition of cdk9 [AID503749, Type: Literature]
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17
[SID104234154]
IC50 0.021Inhibition of HCT116 / VM46 human colon carcinoma cell proliferation [AID81687, Type: Literature]
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18
[SID104234154]
Kd 0.023Binding constant for full-length CDK7 [AID435278, Type: Literature]Cyclin-dependent kinase 7 [gi:1705722]
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19
[SID104234154]
Kd 0.023Binding constant for CDK7 kinase domain [AID624845, Type: Literature]Cyclin-dependent kinase 7 [gi:1705722]
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20
[SID104234154]
GI50 0.023Cytotoxicity against human A2780 cells after 24 hrs by MTT assay [AID741461, Type: Literature]
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