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(1Z,3Z)-1,4-bis(butylsulfonyl)buta-1,3-diene (CID 5286934) - Compound BioActivity Data
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BioActivity Outcomes:
Active(158)
 
 
Inactive(658)
 
 
Inconclusive(53)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
7TM GPCR Srsx(17)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(10)
 
 
BioAssay Types:
Screening(539)
 
 
 
 
Confirmatory(298)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(172)
 
 
 
 
 
IC50(60)
 
 
 
 
EC50(23)
 
 
 
AC50(8)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 797    Data Row: 870   Total Pages: 44   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4251553]
CC50 9.43e-06Cytotoxicity counterscreen assay for transcriptional activators of heat shock protein 70 (Hsp70) [AID1259, Type: confirmatory]
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2
[SID4251553]
Potency 0.0184qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID4251553]
Potency 0.0231qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID4251553]
Potency 0.7079qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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5
[SID4251553]
IC50_Mean 0.72Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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6
[SID4251553]
Potency 0.8913VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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7
[SID4251553]
IC50 1.276Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1692, Type: confirmatory]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
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8
[SID4251553]
IC50 1.35High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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9
[SID4251553]
DR_EC50uM_Run1 1.678Leishmania major promastigote EC50 determinations [AID2008, Type: confirmatory]
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10
[SID4251553]
IC50 1.964Counterscreen for S1P2 Antagonists: Dose Response Cell-Based Screen to Identify Antagonists of CRE-BLA [AID856, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
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11
[SID4251553]
Absolute IC50 (CHOP) 2.12CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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12
[SID4251553]
Potency 2.2387qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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13
[SID4251553]
IC50 2.24A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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14
[SID4251553]
Potency 2.5119qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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15
[SID4251553]
EC50_MICROM 2.541Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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16
[SID4251553]
Absolute IC50 (XBP1) 2.68XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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17
[SID4251553]
EC50 3.038Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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18
[SID4251553]
CC50 3.126A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
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19
[SID4251553]
Potency 3.1623qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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20
[SID4251553]
AC50_uM 3.247Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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