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4-HT (CID 5284643) - Compound BioActivity Data
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BioActivity Outcomes:
Active(100)
 
 
Inactive(93)
 
 
Inconclusive(153)
 
 
Unspecified(22)
 
 
Top Targets:
NR LBD ER(26)
 
 
 
 
NR LBD PPAR(5)
 
 
 
NR LBD TR(4)
 
 
 
HSD10-like SD..(4)
 
 
NR LBD ROR li..(3)
 
 
 
BioAssay Types:
Confirmatory(150)
 
 
 
 
Literature(43)
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(113)
 
 
 
 
IC50(6)
 
 
Ki(4)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 184    Data Row: 368   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169508]
Ki 0.0005Inhibition of [3H]estradiol binding to Estrogen receptor beta [AID238874, Type: Literature]
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2
[SID103169508]
Ki 0.0005Inhibition of [3H]estradiol binding to Estrogen receptor alpha [AID238886, Type: Literature]
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3
[SID103169508]
Ki 0.0005Binding affinity for estrogen receptor alpha [AID70347, Type: Literature]Estrogen receptor [gi:544257]
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4
[SID103169508]
Ki 0.0005Binding affinity for estrogen receptor beta [AID70658, Type: Literature]Estrogen receptor beta [gi:6166154]
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5
[SID103169508]
EC50 0.0008Agonist activity as alkaline phosphatase induction in Ishigawa endometrial cells compared to E2 [AID246597, Type: Literature]Estrogen receptor beta [gi:6166154]
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6
[SID103169508]
EC50 0.0008Agonist activity as alkaline phosphatase induction in Ishigawa endometrial cells compared to E2 [AID246597, Type: Literature]Estrogen receptor [gi:544257]
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7
[SID103169508]
IC50 0.0026Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation [AID248821, Type: Literature]Estrogen receptor [gi:544257]
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8
[SID103169508]
IC50 0.0026Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation [AID248821, Type: Literature]Estrogen receptor beta [gi:6166154]
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9
[SID103169508]
IC50 0.0026Inhibition of estradiol-stimulated MCF-7 breast adenocarcinoma cell proliferation [AID102601, Type: Literature]Estrogen receptor beta [gi:6166154]
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10
[SID103169508]
IC50 0.0026Inhibition of estradiol-stimulated MCF-7 breast adenocarcinoma cell proliferation [AID102601, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID17389512]
Potency 0.0282qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID103169508]
IC50 0.51Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishigawa endometrial cells [AID248974, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID103169508]
IC50 0.51Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishigawa endometrial cells [AID248974, Type: Literature]Estrogen receptor [gi:544257]
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14
[SID103169508]
GI50 1.41254Antiproliferative activity against human MCF7 cells expressing estrogen receptor incubated with 0.003 nM of estradiol and 0.01 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of 5% fetal bovine serum [AID597270, Type: Literature]
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15
[SID103169508]
GI50 1.90546Antiproliferative activity against human MCF7 cells expressing estrogen receptor incubated with 0.06 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597267, Type: Literature]
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16
[SID103169508]
GI50 3.23594Antiproliferative activity against estrogen receptor-deficient human MCF12A cells incubated with 100 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597274, Type: Literature]
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17
[SID103169508]
GI50 3.31131Antiproliferative activity against estrogen receptor-deficient human MCF12A cells incubated with 0.003 nM of estradiol and 0.01 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of 5% fetal bovine serum [AID597272, Type: Literature]
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18
[SID103169508]
GI50 3.46737Antiproliferative activity against human MCF7 cells expressing estrogen receptor incubated with 100 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597271, Type: Literature]
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19
[SID103169508]
GI50 3.89045Antiproliferative activity against estrogen receptor-deficient human MCF12A cells incubated with 0.06 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597273, Type: Literature]
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20
[SID103169508]
GI50 4.46684Antiproliferative activity against estrogen receptor-deficient human NCI-ADR-RES cells incubated with 0.003 nM of estradiol and 0.01 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of 5% fetal bovine serum [AID597266, Type: Literature]
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21
[SID103169508]
GI50 6.16595Antiproliferative activity against estrogen receptor-deficient human NCI-ADR-RES cells incubated with 0.06 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597269, Type: Literature]
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22
[SID103169508]
GI50 7.58578Antiproliferative activity against androgen receptor-deficient human PC3 cells incubated with 0.6 nM of estradiol and 0.7 nM of testosterone after 48 hrs by sulforhodamine B assay [AID597275, Type: Literature]
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23
[SID103169508]
GI50 7.76247Antiproliferative activity against estrogen receptor-deficient human NCI-ADR-RES cells incubated with 100 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597268, Type: Literature]
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24
[SID103169508]
GI50 8.31764Antiproliferative activity against human LNCAP cells expressing androgen receptor incubated with 0.6 nM of estradiol and 0.7 nM of testosterone after 48 hrs by sulforhodamine B assay [AID597277, Type: Literature]
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25
[SID103169508]
GI50 10.7152Antiproliferative activity against androgen receptor-deficient human DU145 cells incubated with 0.6 nM of estradiol and 0.7 nM of testosterone after 48 hrs by sulforhodamine B assay [AID597276, Type: Literature]
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26
[SID17389512]
Potency-Replicate_1 11.2202qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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27
[SID17389512]
Potency 22.3872qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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28
[SID17389512]
Potency 31.6228MultiTox-Fluor Cytotoxicity Assay - LYMP1-002 - Dead Cells [AID960, Type: confirmatory]
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29
[SID17389512]
Potency 33.4915qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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30
[SID17389512]
Potency 39.8107Cell Viability - LYMP2-018 [AID985, Type: confirmatory]
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31
[SID17389512]
Potency 39.8107Cell Viability - LYMP2-026 [AID989, Type: confirmatory]
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32
[SID17389512]
Potency 39.8107Cell Viability - LYMP2-006 [AID978, Type: confirmatory]
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33
[SID17389512]
Potency 39.8107Cell Viability - LYMP2-017 [AID972, Type: confirmatory]
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34
[SID17389512]
Potency 39.8107qHTS assay for small molecule antagonists of retinoid X receptor alpha signaling [AID588546, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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35
[SID17389512]
Potency 50.1187MultiTox-Fluor Cytotoxicity Assay - LYMP1-003 - Dead Cells [AID961, Type: confirmatory]
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36
[SID17389512]
Potency 50.1187MultiTox-Fluor Cytotoxicity Assay - LYMP1-003 - Live Cells [AID962, Type: confirmatory]
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37
[SID17389512]
Potency 50.1187Cell Viability - LYMP1-003 - Assay at 24 hr [AID963, Type: confirmatory]
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38
[SID17389512]
Potency 50.1187Cell Viability - LYMP1-003 - Assay at 40 hr [AID964, Type: confirmatory]
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39
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-025 [AID976, Type: confirmatory]
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40
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-002 [AID977, Type: confirmatory]
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41
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-013 [AID970, Type: confirmatory]
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42
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-005 [AID967, Type: confirmatory]
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43
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-016 [AID984, Type: confirmatory]
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44
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-019 [AID973, Type: confirmatory]
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45
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-021 [AID974, Type: confirmatory]
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46
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-007 [AID979, Type: confirmatory]
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47
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-008 [AID980, Type: confirmatory]
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48
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-010 [AID981, Type: confirmatory]
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49
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-012 [AID982, Type: confirmatory]
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50
[SID17389512]
Potency 50.1187Cell Viability - LYMP2-020 [AID986, Type: confirmatory]
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