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4-HT (CID 5284643) - Compound BioActivity Data
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BioActivity Outcomes:
Active(101)
 
 
Inactive(93)
 
 
Inconclusive(153)
 
 
Unspecified(22)
 
 
Top Targets:
NR LBD ER(26)
 
 
 
 
NR LBD PPAR(5)
 
 
 
NR LBD TR(4)
 
 
 
HSD10-like SD..(4)
 
 
NR LBD ROR li..(3)
 
 
 
BioAssay Types:
Confirmatory(150)
 
 
 
 
Literature(45)
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(114)
 
 
 
 
IC50(6)
 
 
Ki(4)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 184    Data Row: 369   Total Pages: 19   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169508]
Ki 0.0005Binding affinity for estrogen receptor alpha [AID70347, Type: Literature]Estrogen receptor [gi:544257]
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2
[SID103169508]
Ki 0.0005Binding affinity for estrogen receptor beta [AID70658, Type: Literature]Estrogen receptor beta [gi:6166154]
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3
[SID103169508]
Ki 0.0005Inhibition of [3H]estradiol binding to Estrogen receptor beta [AID238874, Type: Literature]
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4
[SID103169508]
Ki 0.0005Inhibition of [3H]estradiol binding to Estrogen receptor alpha [AID238886, Type: Literature]
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5
[SID103169508]
EC50 0.0008Agonist activity as alkaline phosphatase induction in Ishikawa endometrial cells compared to E2 [AID246597, Type: Literature]Estrogen receptor [gi:544257]
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6
[SID103169508]
EC50 0.0008Agonist activity as alkaline phosphatase induction in Ishikawa endometrial cells compared to E2 [AID246597, Type: Literature]Estrogen receptor beta [gi:6166154]
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7
[SID103169508]
IC50 0.0026Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation [AID248821, Type: Literature]Estrogen receptor [gi:544257]
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8
[SID103169508]
IC50 0.0026Inhibition of estradiol-stimulated MCF-7 breast adenocarcinoma cell proliferation [AID102601, Type: Literature]Estrogen receptor [gi:544257]
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9
[SID103169508]
IC50 0.0026Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation [AID248821, Type: Literature]Estrogen receptor beta [gi:6166154]
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10
[SID103169508]
IC50 0.0026Inhibition of estradiol-stimulated MCF-7 breast adenocarcinoma cell proliferation [AID102601, Type: Literature]Estrogen receptor beta [gi:6166154]
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11
[SID17389512]
Potency 0.0282qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID103169508]
IC50 0.51Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishikawa endometrial cells [AID248974, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID103169508]
IC50 0.51Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishikawa endometrial cells [AID248974, Type: Literature]Estrogen receptor [gi:544257]
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14
[SID103169508]
GI50 1.41254Antiproliferative activity against human MCF7 cells expressing estrogen receptor incubated with 0.003 nM of estradiol and 0.01 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of 5% fetal bovine serum [AID597270, Type: Literature]
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15
[SID103169508]
GI50 1.90546Antiproliferative activity against human MCF7 cells expressing estrogen receptor incubated with 0.06 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597267, Type: Literature]
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16
[SID103169508]
GI50 3.23594Antiproliferative activity against estrogen receptor-deficient human MCF12A cells incubated with 100 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597274, Type: Literature]
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17
[SID103169508]
GI50 3.31131Antiproliferative activity against estrogen receptor-deficient human MCF12A cells incubated with 0.003 nM of estradiol and 0.01 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of 5% fetal bovine serum [AID597272, Type: Literature]
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18
[SID103169508]
GI50 3.46737Antiproliferative activity against human MCF7 cells expressing estrogen receptor incubated with 100 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597271, Type: Literature]
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19
[SID103169508]
GI50 3.89045Antiproliferative activity against estrogen receptor-deficient human MCF12A cells incubated with 0.06 nM of estradiol and 0.07 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of fetal bovine serum and NuSerum [AID597273, Type: Literature]
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20
[SID103169508]
GI50 4.46684Antiproliferative activity against estrogen receptor-deficient human NCI-ADR-RES cells incubated with 0.003 nM of estradiol and 0.01 nM of testosterone after 48 hrs by sulforhodamine B assay in presence of 5% fetal bovine serum [AID597266, Type: Literature]
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