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Sirolimus (CID 5284616) - Compound BioActivity Data
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BioActivity Outcomes:
Active(613)
 
 
Inactive(149)
 
 
Inconclusive(72)
 
 
Unspecified(1324)
 
 
Top Targets:
PKc like(65)
 
 
PKc(57)
 
 
STKc AGC(30)
 
 
CYCLIN(26)
 
 
7TM GPCR Srsx(19)
 
 
 
BioAssay Types:
Literature(1175)
 
 
 
 
 
Confirmatory(638)
 
 
 
 
 
Summary(30)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
IC50(502)
 
 
 
Potency(171)
 
 
 
 
 
EC50(6)
 
 
Ki(5)
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1851    Data Row: 2158   Total Pages: 108   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164548]
IC50 8.45e-07SANGER: Inhibition of human MRK-nu-1 cell growth in a cell viability assay. [AID742377, Type: confirmatory]
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2
[SID103164548]
IC50 5.24e-06SANGER: Inhibition of human OCUB-M cell growth in a cell viability assay. [AID741791, Type: confirmatory]
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3
[SID103164548]
IC50 1.16e-05SANGER: Inhibition of human SF539 cell growth in a cell viability assay. [AID741855, Type: confirmatory]
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4
[SID103164548]
IC50 2.15e-05SANGER: Inhibition of human ES4 cell growth in a cell viability assay. [AID742148, Type: confirmatory]
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5
[SID103164548]
EC50 0.0001Antiviral activity against HIV1 R5 assessed as inhibition of cell-cell fusion between R5-envelope expressing HEK293T cells and CD8 depleted human PBMCs pretreated for 6 days [AID406211, Type: Literature]
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6
[SID103164548]
IC50 0.0001Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysis [AID360764, Type: Literature]Serine/threonine-protein kinase mTOR [gi:1169735]
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7
[SID103164548]
IC50 0.000107SANGER: Inhibition of human RL95-2 cell growth in a cell viability assay. [AID741825, Type: confirmatory]
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8
[SID103164548]
EC50 0.00015Antiviral activity against HIV1 ADA in human PBMC assessed as reduction of p24 antigen levels [AID406215, Type: Literature]
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9
[SID103164548]
EC50 0.00018Antiviral activity against HIV1 R5 in human PBMC assessed as fractional inhibition of viral replication [AID406228, Type: Literature]
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10
[SID103164548]
Ki 0.0002Compound was tested for its ability to inhibit FK506 binding protein 12 rotamase activity [AID69108, Type: Literature]
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11
[SID46391895]
Kd 0.0002Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Atomic Structure Of The Rapamycin Human Immunophilin Fkbp- 12 Complex [gi:157831085]
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12
[SID103164548]
IC50 0.000423SANGER: Inhibition of human LC-2-ad cell growth in a cell viability assay. [AID742313, Type: confirmatory]
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13
[SID103164548]
IC50 0.000434SANGER: Inhibition of human Daudi cell growth in a cell viability assay. [AID742128, Type: confirmatory]
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14
[SID103164548]
IC50 0.000443SANGER: Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. [AID741784, Type: confirmatory]
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15
[SID103164548]
IC50 0.00045Inhibitory concentration against binding to FKBP12 [AID254768, Type: Literature]
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16
[SID103164548]
IC50 0.00045Inhibitory concentration against FKBP12 receptor [AID254831, Type: Literature]
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17
[SID103164548]
Kd 0.0005Binding affinity to purified elF4E [AID548276, Type: Literature]
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18
[SID103164548]
ED50 0.0005In Vitro neurotrophic effect was measured in cultured chick DRG sensory neurons. [AID50622, Type: Literature]
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19
[SID103164548]
Ki 0.0005Binding affinity for FK506 binding protein [AID69098, Type: confirmatory]
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20
[SID103164548]
IC50 0.0005Immunosuppressive activity was evaluated by the inhibition of human T-lymphocyte proliferation [AID209953, Type: Literature]
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