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Sirolimus (CID 5284616) - Compound BioActivity Data
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BioActivity Outcomes:
Active(608)
 
 
Inactive(147)
 
 
Inconclusive(73)
 
 
Unspecified(1163)
 
 
Top Targets:
PKc like(65)
 
 
PKc(57)
 
 
STKc AGC(30)
 
 
CYCLIN(26)
 
 
7TM GPCR Srsx(19)
 
 
 
BioAssay Types:
Literature(648)
 
 
 
 
 
Confirmatory(154)
 
 
 
 
 
Summary(30)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
IC50(501)
 
 
 
Potency(169)
 
 
 
 
 
EC50(6)
 
 
Ki(4)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1685    Data Row: 1991   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164548]
IC50 8.45e-07SANGER: Inhibition of human MRK-nu-1 cell growth in a cell viability assay. [AID742377, Type: other]
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2
[SID103164548]
IC50 5.24e-06SANGER: Inhibition of human OCUB-M cell growth in a cell viability assay. [AID741791, Type: other]
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3
[SID103164548]
IC50 1.16e-05SANGER: Inhibition of human SF539 cell growth in a cell viability assay. [AID741855, Type: other]
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4
[SID103164548]
IC50 2.15e-05SANGER: Inhibition of human ES4 cell growth in a cell viability assay. [AID742148, Type: other]
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5
[SID103164548]
EC50 0.0001Antiviral activity against HIV1 R5 assessed as inhibition of cell-cell fusion between R5-envelope expressing HEK293T cells and CD8 depleted human PBMCs pretreated for 6 days [AID406211, Type: Literature]
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6
[SID103164548]
IC50 0.0001Inhibition of mTOR kinase expressed in human HEK293 cells by western blot analysis [AID360764, Type: Literature]Serine/threonine-protein kinase mTOR [gi:1169735]
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7
[SID103164548]
IC50 0.000107SANGER: Inhibition of human RL95-2 cell growth in a cell viability assay. [AID741825, Type: other]
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8
[SID103164548]
EC50 0.00015Antiviral activity against HIV1 ADA in human PBMC assessed as reduction of p24 antigen levels [AID406215, Type: Literature]
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9
[SID103164548]
EC50 0.00018Antiviral activity against HIV1 R5 in human PBMC assessed as fractional inhibition of viral replication [AID406228, Type: Literature]
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10
[SID103164548]
Ki 0.0002Compound was tested for its ability to inhibit FK506 binding protein 12 rotamase activity [AID69108, Type: Literature]
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11
[SID103164548]
IC50 0.000423SANGER: Inhibition of human LC-2-ad cell growth in a cell viability assay. [AID742313, Type: other]
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12
[SID103164548]
IC50 0.000434SANGER: Inhibition of human Daudi cell growth in a cell viability assay. [AID742128, Type: other]
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13
[SID103164548]
IC50 0.000443SANGER: Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. [AID741784, Type: other]
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14
[SID103164548]
IC50 0.00045Inhibitory concentration against binding to FKBP12 [AID254768, Type: Literature]
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15
[SID103164548]
IC50 0.00045Inhibitory concentration against FKBP12 receptor [AID254831, Type: Literature]
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16
[SID103164548]
IC50 0.0005Immunosuppressive activity was evaluated by the inhibition of human T-lymphocyte proliferation [AID209953, Type: Literature]
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17
[SID103164548]
ED50 0.0005In Vitro neurotrophic effect was measured in cultured chick DRG sensory neurons. [AID50622, Type: Literature]
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18
[SID103164548]
Ki 0.0005Binding affinity for FK506 binding protein [AID69098, Type: other]
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19
[SID103164548]
Kd 0.0005Binding affinity to purified elF4E [AID548276, Type: Literature]
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20
[SID103164548]
IC50 0.0006Compound was tested in vitro for its ability to compete with immobilized FK506 for binding to biotinylated FK506 binding protein 12 in a competitive binding assay [AID69125, Type: Literature]
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21
[SID103164548]
IC50 0.000652SANGER: Inhibition of human OS-RC-2 cell growth in a cell viability assay. [AID741797, Type: other]
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22
[SID103164548]
IC50 0.000723SANGER: Inhibition of human VA-ES-BJ cell growth in a cell viability assay. [AID742042, Type: other]
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23
[SID103164548]
IC50 0.000846SANGER: Inhibition of human GR-ST cell growth in a cell viability assay. [AID742183, Type: other]
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24
[SID103164548]
IC50 0.000846SANGER: Inhibition of human SW872 cell growth in a cell viability assay. [AID741914, Type: other]
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25
[SID103164548]
IC50 0.000871SANGER: Inhibition of human NOS-1 cell growth in a cell viability assay. [AID741783, Type: other]
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26
[SID144204421]
Potency-Replicate_1 0.0009qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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27
[SID103164548]
IC50 0.000985SANGER: Inhibition of human MC116 cell growth in a cell viability assay. [AID742339, Type: other]
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28
[SID103164548]
IC50 0.001In vitro immunosuppressive activity by splenocyte mitogenesis assay in spleen cells from BDF1 female mice at 1 pM to 10 uM concentration [AID132664, Type: other]
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29
[SID103164548]
IC50 0.001Inhibitory activity against human concanavalin-A proliferation assay [AID88934, Type: Literature]
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30
[SID103164548]
IC50 0.001Compound was tested in vitro for its ability to inhibit the proliferation of the IL-6-dependent hybridoma clone B13-29-15 [AID93824, Type: Literature]
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31
[SID103164548]
IC50 0.001Compound was tested in vitro for inhibitory activity in the mixed lymphocyte reaction (MLR) assay [AID106878, Type: Literature]
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32
[SID103164548]
IC50 0.00101SANGER: Inhibition of human NCI-H1355 cell growth in a cell viability assay. [AID742405, Type: other]
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33
[SID103164548]
IC50 0.00119SANGER: Inhibition of human RPMI-8226 cell growth in a cell viability assay. [AID741831, Type: other]
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34
[SID103164548]
EC50 0.0013Antiviral activity against HIV1 X4 assessed as inhibition of cell-cell fusion between X4-envelope expressing HEK293T cells and CD8 depleted human PBMCs pretreated for 6 days [AID406212, Type: Literature]
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35
[SID103164548]
IC50 0.00136SANGER: Inhibition of human TE-15 cell growth in a cell viability assay. [AID742013, Type: other]
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36
[SID103164548]
IC50 0.00146SANGER: Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay. [AID741840, Type: other]
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37
[SID103164548]
IC50 0.0016The compound was tested for binding afifnity to FK506 binding protein 12 with an ascomycin conjugate of alkaline phosphatase in a competition binding assay [AID69247, Type: Literature]
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38
[SID103164548]
IC50 0.0016T-cell antiproliferative activity in human mixed lymphocyte reaction [AID257582, Type: Literature]
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39
[SID103164548]
IC50 0.0016Inhibitory activity against FKBP12 [AID257581, Type: Literature]Serine/threonine-protein kinase mTOR [gi:1169735]
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40
[SID103164548]
IC50 0.00201SANGER: Inhibition of human KU812 cell growth in a cell viability assay. [AID742287, Type: other]
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41
[SID103164548]
IC50 0.00217SANGER: Inhibition of human EW-1 cell growth in a cell viability assay. [AID742156, Type: other]
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42
[SID144206303]
Potency-Replicate_1 0.0024qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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43
[SID144204421]
Potency-Replicate_1 0.0024qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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44
[SID144206303]
Potency 0.0024qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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45
[SID103164548]
IC50 0.00245SANGER: Inhibition of human KS-1 cell growth in a cell viability assay. [AID742285, Type: other]
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46
[SID103164548]
IC50 0.0025SANGER: Inhibition of human SK-LMS-1 cell growth in a cell viability assay. [AID741864, Type: other]
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47
[SID103164548]
EC50 0.0025Antiviral activity against HIV1 X4 in human PBMC assessed as reduction of p24 antigen levels [AID406217, Type: Literature]
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48
[SID103164548]
IC50 0.00269SANGER: Inhibition of human TGBC1TKB cell growth in a cell viability assay. [AID742020, Type: other]
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49
[SID144204421]
Potency-Replicate_1 0.0027qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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50
[SID144204421]
ER Potency (uM) 0.0027644qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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