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BioActivity Data for Compound Oxymorphone (CID 5284604)

BioActivity Outcomes:
Active(44)
 
 
Inactive(2)
 
 
Inconclusive(7)
 
 
Unspecified(26)
 
 
Top Targets:
7tm 4(15)
 
 
 
p450(6)
 
 
GT1 Gtf like(2)
 
 
ERG2 Sigma1R(1)
 
 
BioAssay Types:
Literature(75)
 
 
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(4)
 
 
 
Biochemical(45)
 
 
 
ADME(21)
 
 
 
 
Cell-based(14)
 
 
BioActivity Types:
Ki(27)
 
 
 
IC50(8)
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 73    Data Row: 79   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103250876]
IC50 1.3e-05Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl [AID149036, Type: Literature]
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2
[SID103250876]
IC50 0.00015Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl [AID149037, Type: Literature]
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3
[SID103250876]
Ki 0.00054Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation counting [AID603730, Type: Literature]Mu-type opioid receptor [gi:3024265]
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4
[SID103250876]
Ki 0.00078Inhibitory binding constant in guinea pig brain homogenate was reported at mu site at a temperature 25 degree Centigrade labeled with [3H](D-Ala2-MePhe4,Gly-ol5)enkephalin(1 nM) [AID148058, Type: Literature]Mu-type opioid receptor [gi:3024265]
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5
[SID103250876]
Ki 0.00097Inhibition of [3H]DAMGO binding to opioid receptor mu from rat brain membranes [AID239182, Type: Literature]
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6
[SID103250876]
EC50 0.001Binding affinity to rat brain opioid receptor [AID1133438, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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7
[SID103250876]
EC50 0.001Binding affinity to rat brain opioid receptor [AID1133438, Type: Literature]Delta-type opioid receptor [gi:464311]
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8
[SID103250876]
EC50 0.001Binding affinity to rat brain opioid receptor [AID1133438, Type: Literature]Kappa-type opioid receptor [gi:464313]
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9
[SID103250876]
EC50 0.001Binding affinity to rat brain opioid receptor [AID1133438, Type: Literature]Mu-type opioid receptor [gi:464314]
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10
[SID103250876]
IC50 0.0014Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membrane [AID148993, Type: Literature]Mu-type opioid receptor [gi:3024265]
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11
[SID103250876]
Ki 0.00468Displacement of [3H]-DAMGO from mouse MOR/DOR expressed in HEK293 cells [AID692551, Type: Literature]Mu-type opioid receptor [gi:1171911]
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12
[SID103250876]
Ki 0.00468Displacement of [3H]-DAMGO from mouse MOR/DOR expressed in HEK293 cells [AID692551, Type: Literature]Delta-type opioid receptor [gi:417418]
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13
[SID103250876]
Ki 0.00501Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cells [AID692550, Type: Literature]Mu-type opioid receptor [gi:1171911]
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14
[SID103250876]
ID50 0.0121Agonist activity at pig ileum opioid receptor [AID1133437, Type: Literature]
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15
[SID103250876]
Ki 0.015Binding affinity against Opioid receptor mu 1 of guinea pig brain membranes using 0.5 nM of [3H]naloxone as radioligand [AID148045, Type: Literature]Mu-type opioid receptor [gi:3024265]
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16
[SID103250876]
Ki 0.0174Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cells [AID152389, Type: Literature]
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17
[SID103250876]
Ki 0.0231Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293 [AID152387, Type: Literature]
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18
[SID103250876]
ED50 0.024Analgesic potency (antinociceptive activity) (administered icv) at peak time of 10 min in male Swiss-Webster mice [AID128651, Type: Literature]
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19
[SID103250876]
IC50 0.024Agonist activity in the guinea pig ileum longitudinal muscle myenteric plexus. [AID78000, Type: Literature]
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20
[SID103250876]
Ki 0.0262Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293 [AID152385, Type: Literature]
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