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Hydromorphone (CID 5284570) - Compound BioActivity Data
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Filters: All Data » Active      
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BioActivity Outcomes:
Active(9)
 
 
Top Targets:
7TM GPCR Srx(5)
 
 
BioAssay Types:
Literature(8)
 
 
BioActivity Types:
Ki(3)
 
 
EC50(2)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103557031]
Ki 0.00028Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416813, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID103557031]
EC50 0.0026Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417156, Type: Literature]Mu-type opioid receptor [gi:2851402]
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3
[SID103557031]
Ki 0.0028Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID416815, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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4
[SID103557031]
EC50 0.011Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID417160, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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5
[SID103557031]
Ki 0.038Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting [AID416814, Type: Literature]Delta-type opioid receptor [gi:311033488]
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6
[SID103557031]
ED50 0.25Analgesic activity was measured by acetic acid writhing test in mouse by giving subcutaneous injection [AID128495, Type: Literature]
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7
[SID103557031]
ED50 1.34Analgesic activity measured by rat tail flick assay following s.c. administration. [AID177776, Type: Literature]
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8
[SID103557031]
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
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9
[SID48416092]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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