Hydrocodone (CID 5284569) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(112)
 
 
Inconclusive(13)
 
 
Unspecified(18)
 
 
Top Targets:
p450(6)
 
 
Tubulin-bindi..(2)
 
 
RIP(2)
 
 
Peptidase C1A(2)
 
 
PMP22 Claudin(2)
 
 
 
BioAssay Types:
Literature(91)
 
 
 
 
 
Confirmatory(54)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(52)
 
 
 
Ki(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 88    Data Row: 149   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103526751]
Ki 0.0095Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
2
[SID103526751]
Ki 0.0095Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
3
[SID103526751]
Ki 0.0095Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
4
[SID103526751]
Ki 0.0095Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
5
[SID103526751]
Ki 0.26Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670111, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
6
[SID103526751]
Ki 0.26Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670111, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
7
[SID103526751]
Ki 0.26Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670111, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
8
[SID103526751]
Ki 0.26Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670111, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
9
[SID103526751]
ED50 2.4Analgesic activity was measured by acetic acid writhing test in mouse by giving subcutaneous injection [AID128495, Type: Literature]
View
10
[SID103526751]
ED50 5.2Analgesic activity measured by rat tail flick assay following s.c. administration. [AID177776, Type: Literature]
View
11
[SID103526751]
 Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
View
12
[SID48416090]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
View
13
[SID103526751]
 Narcotic agonist activity using acetic acid induced writhing in the mouse upon subcutaneous administration [AID127831, Type: Literature]
View
14
[SID103526751]
 Agonistic activity by mouse acetic acid writhing test. [AID128307, Type: Literature]
View
15
[SID103526751]
 Compound was tested for analgesia in mouse writhing assay by subcutaneous administration [AID128023, Type: Literature]
View
16
[SID103526751]
 Compound was tested for analgesic activity by writhing assay in mouse after subcutaneous administration [AID128027, Type: Literature]
View
17
[SID103526751]
 Narcotic agonistic activity in acetic acid mouse writhing assay after subcutaneous administration of the drug [AID128214, Type: Literature]
View
18
[SID103526751]
 Compound was tested for analgesic activity by tail-flick assay in rat after subcutaneous administration [AID178138, Type: Literature]
View
19
[SID103526751]
 Analgesic agonist activity in heat stimulus rat tail-flick assay on subcutaneous administration [AID178144, Type: Literature]
View
20
[SID103526751]
 Antagonist activity in rat tail flick assay by subcutaneous administration [AID178161, Type: Literature]
View
21
[SID103526751]
 Compound was tested for antinociceptive activity in heat stimulus rat tail flick assay after subcutaneous administration of the drug [AID178325, Type: Literature]
View
22
[SID103526751]
 Effective dose was measured by using rat tail flick assay after subcutaneous administration [AID180157, Type: Literature]
View
23
[SID103526751]
 Lipophilicity, log D at pH7.4 [AID298031, Type: Literature]
View
24
[SID103526751]
 Acid dissociation constant, pKa of the compound [AID298032, Type: Literature]
View
25
[SID103526751]
 Analgesic agonist activity in acetic acid induced mouse writhing assay, subcutaneous administration [AID131018, Type: Literature]
View
26
[SID103526751]
 The effective dose was measured by using mouse writhing assay after the compound administered subcutaneously. [AID132133, Type: Literature]
View
27
[SID103526751]
 Selectivity index, ratio of inhibition of human delta opioid receptor to inhibition of human mu opioid receptor [AID670115, Type: Literature]
View
28
[SID103526751]
 Selectivity index, ratio of inhibition of human kappa opioid receptor to inhibition of human mu opioid receptor [AID670116, Type: Literature]
View
29
[SID29215221]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
View
30
[SID103526751]
 Displacement of [3H]-naltrindole from human delta opioid receptor expressed in CHO cells at 10 uM after 3 hrs by scintillation counting [AID670114, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
31
[SID103526751]
 Displacement of [3H]-naltrindole from human delta opioid receptor expressed in CHO cells at 10 uM after 3 hrs by scintillation counting [AID670114, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
32
[SID29215221]
Potency 112.202qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
View
33
[SID29215221]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
View
34
[SID29215221]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
View
35
[SID29215221]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
View
36
[SID29215221]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
View
37
[SID29215221]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
View
38
[SID29215221]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
View
39
[SID29215221]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
View
40
[SID29215221]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
View
41
[SID29215221]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
View
42
[SID29215221]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
View
43
[SID29215221]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
View
44
[SID29215221]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
45
[SID29215221]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
46
[SID29215221]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
View
47
[SID29215221]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
View
48
[SID29215221]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
View
49
[SID29215221]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
View
50
[SID29215221]
Potency Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View