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Hydrocodone (CID 5284569) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(116)
 
 
Inconclusive(13)
 
 
Unspecified(18)
 
 
Top Targets:
p450(6)
 
 
7TM GPCR Srx(3)
 
 
 
Bromo ALL-1(3)
 
 
Firefly Luc l..(2)
 
 
PLN02808(2)
 
 
BioAssay Types:
Literature(91)
 
 
 
 
 
Confirmatory(56)
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(53)
 
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 87    Data Row: 153   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103526751]
Ki 0.0095Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID103526751]
Ki 0.26Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670111, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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3
[SID103526751]
ED50 2.4Analgesic activity was measured by acetic acid writhing test in mouse by giving subcutaneous injection [AID128495, Type: Literature]
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4
[SID103526751]
ED50 5.2Analgesic activity measured by rat tail flick assay following s.c. administration. [AID177776, Type: Literature]
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5
[SID48416090]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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6
[SID103526751]
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
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7
[SID103526751]
Displacement of [3H]-naltrindole from human delta opioid receptor expressed in CHO cells at 10 uM after 3 hrs by scintillation counting [AID670114, Type: Literature]Delta-type opioid receptor [gi:311033488]
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8
[SID103526751]
Narcotic agonist activity using acetic acid induced writhing in the mouse upon subcutaneous administration [AID127831, Type: Literature]
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9
[SID103526751]
Compound was tested for analgesia in mouse writhing assay by subcutaneous administration [AID128023, Type: Literature]
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10
[SID103526751]
Compound was tested for analgesic activity by writhing assay in mouse after subcutaneous administration [AID128027, Type: Literature]
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11
[SID103526751]
Narcotic agonistic activity in acetic acid mouse writhing assay after subcutaneous administration of the drug [AID128214, Type: Literature]
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12
[SID103526751]
Agonistic activity by mouse acetic acid writhing test. [AID128307, Type: Literature]
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13
[SID29215221]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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14
[SID103526751]
Compound was tested for analgesic activity by tail-flick assay in rat after subcutaneous administration [AID178138, Type: Literature]
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15
[SID103526751]
Analgesic agonist activity in heat stimulus rat tail-flick assay on subcutaneous administration [AID178144, Type: Literature]
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16
[SID103526751]
Antagonist activity in rat tail flick assay by subcutaneous administration [AID178161, Type: Literature]
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17
[SID103526751]
Compound was tested for antinociceptive activity in heat stimulus rat tail flick assay after subcutaneous administration of the drug [AID178325, Type: Literature]
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18
[SID103526751]
Effective dose was measured by using rat tail flick assay after subcutaneous administration [AID180157, Type: Literature]
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19
[SID103526751]
Lipophilicity, log D at pH7.4 [AID298031, Type: Literature]
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20
[SID103526751]
Acid dissociation constant, pKa of the compound [AID298032, Type: Literature]
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