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Hydrocodone (CID 5284569) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(116)
 
 
Inconclusive(13)
 
 
Unspecified(18)
 
 
Top Targets:
p450(6)
 
 
7TM GPCR Srx(3)
 
 
 
Bromo ALL-1(3)
 
 
DUF3652(2)
 
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Literature(91)
 
 
 
 
 
Confirmatory(56)
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(53)
 
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 87    Data Row: 153   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103526751]
Ki 0.0095Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID103526751]
Ki 0.26Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670111, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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3
[SID103526751]
ED50 2.4Analgesic activity was measured by acetic acid writhing test in mouse by giving subcutaneous injection [AID128495, Type: Literature]
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4
[SID103526751]
ED50 5.2Analgesic activity measured by rat tail flick assay following s.c. administration. [AID177776, Type: Literature]
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5
[SID103526751]
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
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6
[SID48416090]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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7
[SID103526751]
Narcotic agonist activity using acetic acid induced writhing in the mouse upon subcutaneous administration [AID127831, Type: Literature]
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8
[SID103526751]
Selectivity index, ratio of inhibition of human delta opioid receptor to inhibition of human mu opioid receptor [AID670115, Type: Literature]
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9
[SID103526751]
Selectivity index, ratio of inhibition of human kappa opioid receptor to inhibition of human mu opioid receptor [AID670116, Type: Literature]
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10
[SID103526751]
Compound was tested for analgesic activity by tail-flick assay in rat after subcutaneous administration [AID178138, Type: Literature]
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11
[SID103526751]
Analgesic agonist activity in heat stimulus rat tail-flick assay on subcutaneous administration [AID178144, Type: Literature]
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12
[SID103526751]
Antagonist activity in rat tail flick assay by subcutaneous administration [AID178161, Type: Literature]
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13
[SID103526751]
Compound was tested for antinociceptive activity in heat stimulus rat tail flick assay after subcutaneous administration of the drug [AID178325, Type: Literature]
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14
[SID103526751]
Compound was tested for analgesia in mouse writhing assay by subcutaneous administration [AID128023, Type: Literature]
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15
[SID103526751]
Compound was tested for analgesic activity by writhing assay in mouse after subcutaneous administration [AID128027, Type: Literature]
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16
[SID103526751]
Narcotic agonistic activity in acetic acid mouse writhing assay after subcutaneous administration of the drug [AID128214, Type: Literature]
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17
[SID103526751]
Agonistic activity by mouse acetic acid writhing test. [AID128307, Type: Literature]
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18
[SID103526751]
Analgesic agonist activity in acetic acid induced mouse writhing assay, subcutaneous administration [AID131018, Type: Literature]
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19
[SID103526751]
The effective dose was measured by using mouse writhing assay after the compound administered subcutaneously. [AID132133, Type: Literature]
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20
[SID103526751]
Effective dose was measured by using rat tail flick assay after subcutaneous administration [AID180157, Type: Literature]
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21
[SID103526751]
Lipophilicity, log D at pH7.4 [AID298031, Type: Literature]
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22
[SID103526751]
Acid dissociation constant, pKa of the compound [AID298032, Type: Literature]
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23
[SID29215221]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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24
[SID103526751]
Displacement of [3H]-naltrindole from human delta opioid receptor expressed in CHO cells at 10 uM after 3 hrs by scintillation counting [AID670114, Type: Literature]Delta-type opioid receptor [gi:311033488]
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25
[SID29215221]
Potency 112.202qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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26
[SID29215221]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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27
[SID29215221]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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28
[SID29215221]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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29
[SID29215221]
Potency S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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30
[SID29215221]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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31
[SID29215221]
Potency qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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32
[SID29215221]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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33
[SID29215221]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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34
[SID29215221]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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35
[SID29215221]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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36
[SID29215221]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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37
[SID29215221]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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38
[SID29215221]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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39
[SID29215221]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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40
[SID29215221]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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41
[SID29215221]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_1, Type: Literature]
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42
[SID29215221]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_2, Type: Literature]
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43
[SID29215221]
Potency Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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44
[SID29215221]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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45
[SID29215221]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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46
[SID29215221]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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47
[SID29215221]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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48
[SID29215221]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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49
[SID29215221]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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50
[SID29215221]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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