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Toxaphene (CID 5284469) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(294)
 
 
Inactive(118)
 
 
Inconclusive(152)
 
 
Unspecified(4)
 
 
Top Targets:
NR LBD ER(16)
 
 
 
 
NR LBD AR(16)
 
 
 
 
NR LBD PPAR(15)
 
 
 
 
NR LBD TR(10)
 
 
 
 
NR LBD GR(10)
 
 
BioAssay Types:
Confirmatory(286)
 
 
 
 
Literature(63)
 
 
 
 
Summary(39)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(280)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 273    Data Row: 568   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389704]
Potency 1.9012Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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2
[SID17389704]
Potency 2.6855Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID144204724]
Potency-Replicate_1 2.9849qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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4
[SID144204724]
Potency-Replicate_1 3.7578qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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5
[SID144208110]
Potency-Replicate_1 3.8101qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144208110]
Potency-Replicate_1 4.275qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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7
[SID144208110]
Potency-Replicate_1 4.275qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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8
[SID144204724]
Ratio Potency (uM) 4.27944qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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9
[SID144204724]
Potency-Replicate_1 4.7308qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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10
[SID17389704]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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11
[SID144204724]
Potency-Replicate_1 5.308qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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12
[SID144204724]
Potency-Replicate_1 5.9557qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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13
[SID144204724]
Potency-Replicate_1 5.9557qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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14
[SID144208110]
Ratio Potency (uM) 8.86335qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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15
[SID144208110]
Ratio Potency (uM) 9.57043qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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16
[SID144204724]
Potency-Replicate_1 10.5909qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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17
[SID144204724]
Potency-Replicate_1 13.4481qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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18
[SID17389704]
Potency 14.1254qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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19
[SID144208110]
Potency-Replicate_1 17.0189qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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20
[SID144208110]
Potency-Replicate_1 17.1764qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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21
[SID144208110]
Potency-Replicate_1 21.4255qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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22
[SID144208110]
Potency-Replicate_1 21.6238qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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23
[SID144208110]
Potency-Replicate_1 21.6238qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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24
[SID144204724]
Potency-Replicate_1 23.9145qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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25
[SID144208110]
Potency-Replicate_1 24.0398qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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26
[SID144204724]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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27
[SID144204724]
Ratio Potency (uM) 26.8062qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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28
[SID144204724]
Ratio Potency (uM) 26.8325qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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29
[SID144204724]
Potency-Replicate_1 26.8325qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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30
[SID144204724]
Potency-Replicate_1 29.8493qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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31
[SID144204724]
Potency-Replicate_1 29.8493qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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32
[SID144208110]
Potency-Replicate_1 30.2644qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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33
[SID17389704]
Potency 31.6228Cell Viability - LYMP2-008 [AID980, Type: confirmatory]
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34
[SID17389704]
Potency 31.6228MultiTox-Fluor Cytotoxicity Assay - LYMP1-002 - Dead Cells [AID960, Type: confirmatory]
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35
[SID144208110]
Potency-Replicate_1 34.2714qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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36
[SID17389704]
Potency 36.1254S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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37
[SID17389704]
Potency 37.578qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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38
[SID17389704]
Potency 39.8107qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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39
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-004 [AID966, Type: confirmatory]
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40
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-010 [AID981, Type: confirmatory]
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41
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-012 [AID982, Type: confirmatory]
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42
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-019 [AID973, Type: confirmatory]
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43
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-009 [AID968, Type: confirmatory]
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44
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-015 [AID971, Type: confirmatory]
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45
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-001 [AID921, Type: confirmatory]
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46
[SID17389704]
Potency 39.8107qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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47
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-022 [AID987, Type: confirmatory]
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48
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-024 [AID988, Type: confirmatory]
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49
[SID17389704]
Potency 39.8107Cell Viability - LYMP2-007 [AID979, Type: confirmatory]
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50
[SID144208110]
Potency-Replicate_1 48.4096qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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