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Calcifediol (CID 5283731) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(32)
 
 
Inactive(119)
 
 
Inconclusive(60)
 
 
Unspecified(6)
 
 
Top Targets:
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
Bromo ALL-1(5)
 
 
NR LBD TR(5)
 
 
 
 
NR LBD ROR li..(4)
 
 
 
 
BioAssay Types:
Confirmatory(116)
 
 
 
 
Literature(72)
 
 
 
 
 
Summary(15)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(125)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 139    Data Row: 217   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144205540]
Potency-Replicate_1 5.308qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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2
[SID144205540]
Ratio Potency (uM) 5.81729qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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3
[SID144205540]
Potency-Replicate_1 5.9557qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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4
[SID144205540]
Potency-Replicate_1 5.9557qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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5
[SID144205540]
Potency-Replicate_1 6.6824qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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6
[SID144205540]
Potency-Replicate_1 6.6824qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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7
[SID50110817]
Potency 10.5931A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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8
[SID144205540]
Potency-Replicate_1 10.6822qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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9
[SID50110817]
Potency 11.2202VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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10
[SID144205540]
Potency-Replicate_1 11.8832qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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11
[SID144205540]
Potency-Replicate_1 11.8832qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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12
[SID144205540]
Potency 12.5893qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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13
[SID144205540]
Potency-Replicate_1 13.3332qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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14
[SID144205540]
Potency-Replicate_1 23.9145qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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15
[SID144205540]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144205540]
Ratio Potency (uM) 26.8325qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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17
[SID144205540]
AR Potency (uM) 28.7255qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
18
[SID48415681]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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19
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_60, Type: Literature]
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20
[SID103279820]
Inhibition of Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as down regulation of Gli1 at 0.5 to 5 uM after 24 hrs by RT-PCR analysis [AID647370, Type: Literature]
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21
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_52, Type: Literature]
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22
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_53, Type: Literature]
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23
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_54, Type: Literature]
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24
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_56, Type: Literature]
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25
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_57, Type: Literature]
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26
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_46, Type: Literature]
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27
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_32, Type: Literature]
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28
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_26, Type: Literature]
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29
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_19, Type: Literature]
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30
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_20, Type: Literature]
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31
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_11, Type: Literature]
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32
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_4, Type: Literature]
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33
[SID103279820]
Compound was evaluated for chick Vasoactive intestinal peptide receptor relative competitive indices (relative to alpha, 25-(OH2)-D3) [AID216929, Type: Literature]
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34
[SID103279820]
Keq (k1/1-k) for the transformation of vitamin D to previtamin D [AID228114, Type: Literature]
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35
[SID50110817]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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36
[SID103279820]
Compound was tested for the backward reaction of conversion of vitamin D to previtaminD [AID25537, Type: Literature]
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37
[SID103279820]
Compound was tested for rate constant for the forward reaction of isomerization of previtamin D to vitamin D [AID25549, Type: Literature]
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38
[SID103279820]
Activation of VDR in mouse C3H10T1/2 cells assessed as up-regulation of CYP24A1 after 24 hrs by RT-PCR analysis relative to control [AID647368, Type: Literature]Vitamin D3 receptor [gi:342187016]
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39
[SID26754888]
Potency 25.1189qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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40
[SID144205540]
Potency qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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41
[SID26754888]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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42
[SID26754888]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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43
[SID26754888]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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44
[SID26754888]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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45
[SID92308917]
Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection [AID720717, Type: other]ORF 73 [Human herpesvirus 8 type M] [gi:1718329]
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46
[SID92309827]
Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection [AID720717, Type: other]ORF 73 [Human herpesvirus 8 type M] [gi:1718329]
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47
[SID50110817]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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48
[SID26754888]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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49
[SID26754888]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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50
[SID50110817]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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