sphingosine 1-phosphate (CID 5283560) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(54)
 
 
Inactive(76)
 
 
Inconclusive(1)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
 
Tubulin-bindi..(4)
 
 
Peptidase C1A(4)
 
 
PLN02808(4)
 
 
NR LBD TR(4)
 
 
BioAssay Types:
Confirmatory(72)
 
 
 
Literature(61)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(68)
 
 
EC50(34)
 
 
IC50(14)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 106    Data Row: 138   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103513044]
EC50 2.7e-05Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay [AID473717, Type: Literature]Sphingosine 1-phosphate receptor 1 [gi:205371820]
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2
[SID103513044]
EC50 2.7e-05Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay [AID473717, Type: Literature]Sphingosine 1-phosphate receptor 1 [gi:205371820]
View
3
[SID103513044]
IC50 0.00026Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cells [AID282269, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
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4
[SID103513044]
IC50 0.00026Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cells [AID282269, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
5
[SID103513044]
IC50 0.00026Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cells [AID282269, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
6
[SID103513044]
IC50 0.00035Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells [AID282268, Type: Literature]Sphingosine 1-phosphate receptor 2 [gi:38257367]
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7
[SID103513044]
IC50 0.00035Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells [AID282268, Type: Literature]Sphingosine 1-phosphate receptor 2 [gi:38257367]
View
8
[SID103513044]
IC50 0.00035Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells [AID282268, Type: Literature]Sphingosine 1-phosphate receptor 2 [gi:38257367]
View
9
[SID103513044]
EC50 0.000449Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay [AID473718, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
10
[SID103513044]
EC50 0.000449Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay [AID473718, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
11
[SID103513044]
EC50 0.000449Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assay [AID473718, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
12
[SID103513044]
IC50 0.00047Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor [AID392389, Type: Literature]Sphingosine 1-phosphate receptor 1 [gi:205371820]
View
13
[SID103513044]
IC50 0.00047Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor [AID392389, Type: Literature]Sphingosine 1-phosphate receptor 1 [gi:205371820]
View
14
[SID103513044]
EC50 0.00055Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay [AID305220, Type: Literature]Sphingosine 1-phosphate receptor 1 [gi:205371820]
View
15
[SID103513044]
EC50 0.00055Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay [AID305220, Type: Literature]Sphingosine 1-phosphate receptor 1 [gi:205371820]
View
16
[SID103513044]
IC50 0.00055Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cells [AID282271, Type: Literature]
View
17
[SID103513044]
IC50 0.00066Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor [AID392390, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
18
[SID103513044]
IC50 0.00066Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor [AID392390, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
19
[SID103513044]
IC50 0.00066Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor [AID392390, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
20
[SID103513044]
IC50 0.00067Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cells [AID282267, Type: Literature]Sphingosine 1-phosphate receptor 1 [gi:205371820]
View
21
[SID103513044]
IC50 0.00067Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cells [AID282267, Type: Literature]Sphingosine 1-phosphate receptor 1 [gi:205371820]
View
22
[SID103513044]
EC50 0.0007Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay [AID481646, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
23
[SID103513044]
EC50 0.0007Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay [AID481646, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
24
[SID103513044]
EC50 0.0007Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay [AID481646, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
25
[SID103513044]
EC50 0.0009In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) [AID204032, Type: Literature]
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26
[SID103513044]
EC50 0.00091Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay [AID305223, Type: Literature]Sphingosine 1-phosphate receptor 5 [gi:62510663]
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27
[SID103513044]
EC50 0.00091Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay [AID305223, Type: Literature]Sphingosine 1-phosphate receptor 5 [gi:62510663]
View
28
[SID103513044]
IC50 0.0011Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor [AID392392, Type: Literature]Sphingosine 1-phosphate receptor 5 [gi:62510663]
View
29
[SID103513044]
IC50 0.0011Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor [AID392392, Type: Literature]Sphingosine 1-phosphate receptor 5 [gi:62510663]
View
30
[SID103513044]
EC50 0.0011In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) [AID204047, Type: Literature]
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31
[SID103513044]
EC50 0.0012In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand [AID240302, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
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32
[SID103513044]
EC50 0.0012In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand [AID240302, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
33
[SID103513044]
EC50 0.0012In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand [AID240302, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
34
[SID103513044]
EC50 0.0016Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay [AID305221, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
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35
[SID103513044]
EC50 0.0016Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay [AID305221, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
36
[SID103513044]
EC50 0.0016Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay [AID305221, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
37
[SID103513044]
EC50 0.0017In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand [AID240304, Type: Literature]Sphingosine 1-phosphate receptor 5 [gi:62510663]
View
38
[SID103513044]
EC50 0.0017In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand [AID240304, Type: Literature]Sphingosine 1-phosphate receptor 5 [gi:62510663]
View
39
[SID103513044]
EC50 0.0022In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand [AID240301, Type: Literature]Sphingosine 1-phosphate receptor 2 [gi:38257367]
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40
[SID103513044]
EC50 0.0022In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand [AID240301, Type: Literature]Sphingosine 1-phosphate receptor 2 [gi:38257367]
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41
[SID103513044]
EC50 0.0022In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand [AID240301, Type: Literature]Sphingosine 1-phosphate receptor 2 [gi:38257367]
View
42
[SID103513044]
IC50 0.0024Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor [AID392391, Type: Literature]Sphingosine 1-phosphate receptor 4 [gi:42558945]
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43
[SID103513044]
IC50 0.0024Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor [AID392391, Type: Literature]Sphingosine 1-phosphate receptor 4 [gi:42558945]
View
44
[SID103513044]
IC50 0.0029Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting [AID481652, Type: Literature]Sphingosine 1-phosphate receptor 4 [gi:42558945]
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45
[SID103513044]
IC50 0.0029Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting [AID481652, Type: Literature]Sphingosine 1-phosphate receptor 4 [gi:42558945]
View
46
[SID103513044]
EC50 0.0029In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 1) [AID204039, Type: Literature]
View
47
[SID103513044]
EC50 0.003Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding [AID392395, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
48
[SID103513044]
EC50 0.003Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding [AID392395, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
49
[SID103513044]
EC50 0.003Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS binding [AID392395, Type: Literature]Sphingosine 1-phosphate receptor 3 [gi:42560554]
View
50
[SID103513044]
EC50 0.0045Effective concentration required for [35S]GTP-gamma-S binding towards Sphingosine 1-phosphate receptor G-protein complex expressed in HEK293T cells [AID255662, Type: Literature]
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