Thromboxane B2 (CID 5283137) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Inactive(35)
 
 
Inconclusive(1)
 
 
Unspecified(9)
 
 
Top Targets:
ABCC MRP doma..(2)
 
 
Tubulin-bindi..(2)
 
 
Peptidase C1A(2)
 
 
PLN02808(2)
 
 
HELICc(2)
 
 
BioAssay Types:
Confirmatory(34)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(32)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 45   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160693341]
Km 0.423TP_TRANSPORTER: uptake in PGT-expressing HeLa cells [AID681576, Type: other]Solute carrier organic anion transporter family member 2A1 [gi:357529156]
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2
[SID160693341]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681367, Type: other]Solute carrier organic anion transporter family member 3A1 [gi:296452954]
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3
[SID160693341]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681173, Type: other]Solute carrier organic anion transporter family member 2B1 [gi:27734548]
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4
[SID160693341]
 TP_TRANSPORTER: inhibition of alaninyl-d4TMP in the presence of Thromboxane B2 at a concentration of 20uM in membrane vesicles from MRP1-expressing Sf9 cells [AID681092, Type: other]Multidrug resistance-associated protein 1 [gi:296439301]
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5
[SID160693341]
 TP_TRANSPORTER: inhibition of alaninyl-d4TMP in the presence of Thromboxane B2 at a concentration of 20uM in membrane vesicles from MRP1-expressing Sf9 cells [AID681092, Type: other]Multidrug resistance-associated protein 1 [gi:296439301]
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6
[SID160693341]
 TP_TRANSPORTER: inhibition of alaninyl-d4TMP by Thromboxane B2 at a concentration of 20uM in membrane vesicle from MRP5-expressing HEK293 cells [AID681870, Type: other]Multidrug resistance-associated protein 5 [gi:8928547]
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7
[SID160693341]
 TP_TRANSPORTER: inhibition of alaninyl-d4TMP in the presence of Thromboxane B2 at a concentration of 20uM in membrane vesicles from MRP4-expressing Sf9 cells [AID681886, Type: other]Multidrug resistance-associated protein 4 [gi:206729914]
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8
[SID160693341]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681342, Type: other]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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9
[SID160693341]
 TP_TRANSPORTER: uptake in PGT-expressing HeLa cells [AID682149, Type: other]Solute carrier organic anion transporter family member 2A1 [gi:218511799]
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10
[SID160693341]
 TP_TRANSPORTER: inhibition of alaninyl-d4TMP by Thromboxane B2 at a concentration of 20uM in membrane vesicle from MRP3-expressing Sf9 cells [AID680416, Type: other]Multidrug resistance associated protein [gi:74761045]
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11
[SID26754848]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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12
[SID26754848]
Potency qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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13
[SID26754848]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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14
[SID26754848]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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15
[SID26754848]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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16
[SID26754848]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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17
[SID26754848]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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18
[SID26754848]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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19
[SID26754848]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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20
[SID26754848]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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21
[SID26754848]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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22
[SID26754848]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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23
[SID26754848]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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24
[SID26754848]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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25
[SID26754848]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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26
[SID26754848]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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27
[SID26754848]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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28
[SID26754848]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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29
[SID26754848]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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30
[SID26754848]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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31
[SID26754848]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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32
[SID26754848]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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33
[SID26754848]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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34
[SID26754848]
Potency qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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35
[SID26754848]
Potency qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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36
[SID26754848]
Potency qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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37
[SID26754848]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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38
[SID26754848]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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39
[SID26754848]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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40
[SID26754848]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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41
[SID26754848]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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42
[SID26754848]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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43
[SID26754848]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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44
[SID26754848]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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45
[SID26754848]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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46
[SID26754848]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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47
[SID26754848]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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48
[SID26754848]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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49
[SID26754848]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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50
[SID26754848]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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